Search Results - "Nordenskjöld, B"

Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer by Lundgren, K, Nordenskjöld, B, Landberg, G

“…Background: Hypoxia is an element of the tumour microenvironment that impacts upon numerous cellular factors linked to clinical aggressiveness in cancer. One…”
Get full text

Prognostic utility of HOXB13 : IL17BR and molecular grade index in early-stage breast cancer patients from the Stockholm trial by Jerevall, P-L, Ma, X-J, Li, H, Salunga, R, Kesty, N C, Erlander, M G, Sgroi, D C, Holmlund, B, Skoog, L, Fornander, T, Nordenskjöld, B, Stål, O

“…Background: A dichotomous index combining two gene expression assays, HOXB13 : IL17BR (H : I) and molecular grade index (MGI), was developed to assess risk of…”
Get full text

Survival patterns of invasive lobular and invasive ductal breast cancer in a large population-based cohort with two decades of follow up by Chamalidou, C., Fohlin, H., Albertsson, P., Arnesson, L.-G., Einbeigi, Z., Holmberg, E., Nordenskjöld, A., Nordenskjöld, B., Karlsson, P., Linderholm, B.

“…Invasive lobular carcinoma (ILC) comprises 8–15 % of all invasive breast cancers and large population-based studies with >10 years of follow-up are rare…”
Get full text

Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer by BOSTNER, J, AHNSTRÖM WALTERSSON, M, FORNANDER, T, SKOOG, L, NORDENSKJÖLD, B, STAL, O

“…The 11q13 region is amplified in approximately 15% of all breast tumors. Situated in this region are the cyclin D1 gene (CCND1) and the p-21-activated kinase 1…”
Get full text

No clear effect of postoperative radiotherapy on survival of breast cancer patients with one to three positive nodes: a population-based study by Nordenskjöld, A.E., Fohlin, H., Albertsson, P., Arnesson, L.G., Chamalidou, C., Einbeigi, Z., Holmberg, E., Nordenskjöld, B., Karlsson, P.

“…In published radiotherapy trials, the failure rate in the control arm among patients with one to three positive nodes is high compared with that seen with…”
Get full text

Androgen receptor expression predicts beneficial tamoxifen response in oestrogen receptor-α-negative breast cancer by Hilborn, Erik, Gacic, Jelena, Fornander, Tommy, Nordenskjöld, Bo, Stål, Olle, Jansson, Agneta

“…Background: Although the androgen receptor (AR) is frequently expressed in breast cancer, its relevance in the disease is not fully understood. In addition,…”
Get full text

Effects of adjuvant tamoxifen over three decades on breast cancer–free and distant recurrence–free interval among premenopausal women with oestrogen receptor–positive breast cancer randomised in the Swedish SBII:2pre trial by Ekholm, M., Bendahl, P.O., Fernö, M., Nordenskjöld, B., Stål, O., Rydén, L.

“…The primary aim was to compare 2 years of adjuvant tamoxifen versus no systemic treatment in premenopausal patients with oestrogen receptor (ER)–positive…”
Get full text

Oestrogen receptor co-activator AIB1 is a marker of tamoxifen benefit in postmenopausal breast cancer by Weiner, M., Skoog, L., Fornander, T., Nordenskjöld, B., Sgroi, D.C., Stål, O.

“…The oestrogen receptor (ER) co-activator amplified in breast cancer 1 (AIB1) has been suggested as a treatment predictive and prognostic marker in breast…”
Get full text

Long-term effects of mammography screening: updated overview of the Swedish randomised trials by Nyström, Lennarth, Andersson, Ingvar, Bjurstam, Nils, Frisell, Jan, Nordenskjöld, Bo, Rutqvist, Lars Erik

“…There has been much debate about the value of screening mammography. Here we update the overview of the Swedish randomised controlled trials on mammography…”
Get full text

Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients by Wegman, Pia, Vainikka, Linda, Stål, Olle, Nordenskjöld, Bo, Skoog, Lambert, Rutqvist, Lars-Erik, Wingren, Sten

“…Tamoxifen is widely used as endocrine therapy for oestrogen-receptor-positive breast cancer. However, many of these patients experience recurrence despite…”
Get full text

Overall survival benefit for sequential doxorubicin–docetaxel compared with concurrent doxorubicin and docetaxel in node-positive breast cancer—8-year results of the Breast International Group 02-98 phase III trial by Oakman, C., Francis, P.A., Crown, J., Quinaux, E., Buyse, M., De Azambuja, E., Margeli Vila, M., Andersson, M., Nordenskjöld, B., Jakesz, R., Thürlimann, B., Gutiérrez, J., Harvey, V., Punzalan, L., Dell'Orto, P., Larsimont, D., Steinberg, I., Gelber, R.D., Piccart-Gebhart, M., Viale, G., Di Leo, A.

“…In women with node-positive breast cancer, the Breast International Group (BIG) 02-98 tested the incorporation of docetaxel (Taxotere) into doxorubicin…”
Get full text

Increased long-term risk of fatal breast cancer in patients with high intra-tumor heterogeneity of the estrogen receptor – Retrospective analyses of the STO-3 trial by Lindström, L.S., Yau, C., Czene, K., Thompson, C., Yu, N., Nordenskjöld, B., Stål, O., Benz, C.C., Fornander, T., Borowsky, A.D., Esserman, L.

Get full text

Low RAB6C expression is a predictor of tamoxifen benefit in estrogen receptor-positive/progesterone receptor-negative breast cancer by Fohlin, Helena, Bekkhus, Tove, Sandström, Josefine, Fornander, Tommy, Nordenskjöld, Bo, Carstensen, John, Stål, Olle

“…Over the last few decades, improved and more individualized treatment has contributed to the increased survival rate of patients with breast cancer. However,…”
Get full text

Time dependent effects of adjuvant tamoxifen therapy on cerebrovascular disease: results from a randomised trial by Rosell, J, Nordenskjöld, B, Bengtsson, N-O, Fornander, T, Hatschek, T, Lindman, H, Malmström, P-O, Wallgren, A, Stål, O, Carstensen, J

“…Background: Tamoxifen has been associated with an increased risk of stroke. There is, however, little information on the effect in the post-treatment period…”
Get full text

IP6K2 predicts favorable clinical outcome of primary breast cancer by Sandström, Josefine, Balian, Alien, Lockowandt, Rebecca, Fornander, Tommy, Nordenskjöld, Bo, Lindström, Linda, Pérez-Tenorio, Gizeh, Stål, Olle

“…The inositol hexakisphosphate kinase ( ) 1 and 2 genes are localized at 3p21.31, a highly altered gene-dense chromosomal region in cancer. The IP6Ks convert…”
Get full text

1812 Intra-tumor heterogeneity of the estrogen receptor predicts less benefit from tamoxifen therapy and poor long-term breast cancer patient survival. Retrospective analyses of the STO3 randomizedtrial by Lindström, L.S, Yau, C, Czene, K, Thompson, C.K, Van't Veer, L.J, Nordenskjöld, B, Stål, O, Fornander, T, Benz, C.C, Borowsky, A.D, Esserman, L.J

Get full text

Prolonged tamoxifen treatment increases relapse-free survival for patients with primary breast cancer expressing high levels of VEGF by Sanchez, B.C, Sundqvist, M, Fohlin, H, Spyratos, F, Nordenskjöld, B, Stål, O, Linderholm, B.K

“…Abstract Previous retrospective studies have shown that high intratumoural levels of vascular endothelial growth factor (VEGF) correlate with an inferior…”
Get full text

Coronary Heart Disease Mortality After 5 Years of Adjuvant Tamoxifen Therapy: Results from a Randomized Trial by Nordenskjöld, Bo, Rosell, Johan, Rutqvist, Lars-Erik, Malmström, Per-Olof, Bergh, Jonas, Bengtsson, Nils-Olof, Hatschek, Thomas, Wallgren, Arne, Carstensen, John

“…From January 1, 1983, through December 31, 1992, a total of 4610 patients entered a randomized trial that compared mortality among patients receiving 2 years…”
Get full text

Akt kinases in breast cancer and the results of adjuvant therapy by Stål, Olle, Pérez-Tenorio, Gizeh, Akerberg, Linda, Olsson, Birgit, Nordenskjöld, Bo, Skoog, Lambert, Rutqvist, Lars Erik

“…The serine/threonine kinase Akt, or protein kinase B, has recently been a focus of interest because of its activity to inhibit apoptosis. It mediates cell…”
Get full text

Gene expression profiling in primary breast cancer distinguishes patients developing local recurrence after breast-conservation surgery, with or without postoperative radiotherapy by Niméus-Malmström, Emma, Krogh, Morten, Malmström, Per, Strand, Carina, Fredriksson, Irma, Karlsson, Per, Nordenskjöld, Bo, Stål, Olle, Ostberg, Görel, Peterson, Carsten, Fernö, Mårten

“…Some patients with breast cancer develop local recurrence after breast-conservation surgery despite postoperative radiotherapy, whereas others remain free of…”
Get full text