Search Results - "Nordblom, G D"

Validation of immunoassays for bioanalysis: a pharmaceutical industry perspective by Findlay, J.W.A., Smith, W.C., Lee, J.W., Nordblom, G.D., Das, I., DeSilva, B.S., Khan, M.N., Bowsher, R.R.

“…Immunoassays are bioanalytical methods in which quantitation of the analyte depends on the reaction of an antigen (analyte) and an antibody. Although…”
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Immunochemical Evidence for Induction of the Alcohol-Oxidizing Cytochrome P-450 of Rabbit Liver Microsomes by Diverse Agents: Ethanol, Imidazole, Trichloroethylene, Acetone, Pyrazole, and Isoniazid by Koop, Dennis R., Crump, Becky L., Nordblom, Gerald D., Coon, Minor J.

“…Isozyme 3a of rabbit liver microsomal cytochrome P-450, also termed P-450ALC, was previously isolated in this laboratory from animals administered ethanol or…”
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On-Probe Immunoaffinity Extraction by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry by Liang, Xiaoli, Lubman, David M, Rossi, David T, Nordblom, Gerald D, Barksdale, Charles M

“…A simple and effective method has been proposed in this work for combination of immunoaffinity extraction with MALDI MS. In this method, an antibody is…”
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Glucuronidation of Prodrug Reactive Site: Isolation and Characterization of Oxymethylglucuronide Metabolite of Fosphenytoin by Annesley, Thomas M, Kurzyniec, Stephen, Nordblom, Gerald D, Buchanan, Nathan, Pool, William, Reily, Michael, Talaat, Rasmy, Roberts, William L

“…This investigation was undertaken to identify the structure of a novel immunoreactive metabolite derived from fosphenytoin that has been hypothesized…”
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Cross-reactivity of fosphenytoin in two human plasma phenytoin immunoassays by Kugler, Alan R, Annesley, Thomas M, Nordblom, Gerald D, Koup, Jeffrey R, Olson, Stephen C

“…The cross-reactivity of fosphenytoin, a phosphate ester prodrug of phenytoin, was investigated in the Abbott phenytoin TDx/TDxFLx fluorescence polarization…”
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Perturbation of epidermal growth factor clearance after radioiodination and its implications by Kuo, B S, Nordblom, G D, Wright, D S

“…The clearance of human epidermal growth factor (hEGF1-53) has been thought to be mediated mainly by a high-capacity receptor system, yet relatively low in vivo…”
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Clinical pharmacokinetics and relative bioavailability of oral procaterol by ELDON, M. A, BATTLE, M. M, COON, M. J, NORDBLOM, G. D, SEDMAN, A. J, COLBURN, W. A

“…The pharmacokinetics and relative oral bioavailability of procaterol, an orally active beta 2-adrenergic agonist bronchodilator were evaluated in healthy…”
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Immunochemical evidence for a role of cytochrome P-450 in liver microsomal ethanol oxidation by Koop, D R, Nordblom, G D, Coon, M J

“…Antibodies to cytochrome P-450 isozyme 3a, the ethanol-inducible isozyme in rabbit liver, were used to determine the role of this enzyme in the microsomal…”
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Development and validation of two solid-phase enzyme immunoassays (ELISA) for quantitation of human epidermal growth factors (hEGFs) by SIZEMORE, N, DUDECK, R. C, BARKSDALE, C. M, NORDBLOM, G. D, MUELLER, W. T, MCCONNELL, P, WRIGHT, D. S, GUGLIETTA, A, KUO, B.-S

“…The purpose of the present investigation was to develop and validate two separate enzyme-linked immunosorbent assays (ELISA) for quantitation of exogenous…”
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Disposition kinetics of human epidermal growth factor (hEGF1-53) and its truncated fragment (hEGF1-48) in rats by Kuo, B S, Nordblom, G D, Dudeck, R C, Kirkish, L S, Wright, D S

“…Clearance of human epidermal growth factor (hEGF1-53) has been proposed to be mediated by a receptor pathway involving a typical cascade of ligand-receptor…”
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Pharmacokinetics and pharmacodynamics of CI-992 following intravenous and oral administration to cynomolgus monkeys by Cook, Jack A., Burger, Paula J., Michniewicz, Barbara M., Nordblom, Gerald D., Hicks, Gary W., Kaplan, Charles, Ryan, Michael J.

“…The purpose of this study was to characterize CI‐992 pharmacokinetics and pharmacokinetics/pharmacodynamics (PK/PD) in sodium deplete monkeys. Panels of…”
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Considerations in the development of a sensitive HPLC assay for human epidermal growth factors in human plasma by Kagel, John R., Rossi, David T., Nordblom, Gerald D., Dudeck, Richard C., Barksdale, Charles M., Kuo, Be-Sheng, Wright, D.Scott

“…A sensitive assay was developed for human epidermal growth factors (hEGF) 1–48 (dosed), hEGF 1–53 (endogenous), without interference from potential metabolites…”
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Clinical pharmacokinetics of procaterol: dose proportionality after administration of single oral doses by Eldon, M A, Blake, D S, Coon, M J, Nordblom, G D, Sedman, A J, Colburn, W A

“…Procaterol is a potent, orally active beta 2-agonist bronchodilator useful in the treatment of reversible bronchospastic disease. It is effective when…”
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Development of a radioimmunoassay for the anthrapyrazole chemotherapy agent CI-937 and the pharmacokinetics of CI-937 in rats by NORDBLOM, G. D, PACHLA, L. A, TSUNG CHANG, WHITFIELD, L. R, SHOWALTER, H. D. H

“…The anthracyclines daunorubicin and doxorubicin are cancer chemotherapy agents that complex DNA and are widely utilized clinically. Cumulative cardiotoxicity,…”
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Assays for cytochrome P-450 peroxygenase activity by Coon, M J, Blake, 2nd, R C, White, R E, Nordblom, G D

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Simple, comprehensive correlation of organic oxidation and ionization potentials by Miller, Larry L, Nordblom, G. D, Mayeda, Edward A

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Lectin binding studies on murine peritoneal cells: physicochemical characterization of the binding of lectins from Datura stramonium, Evonymus europaea, and Griffonia simplicifolia to murine peritoneal cells by Petryniak, J, Huard, T K, Nordblom, G D, Goldstein, I J

“…Purified 125I-labeled lectins from Datura stramonium, Evonymus europaea, and Griffonia simplicifolia (I-B4 isolectin) were used to analyze changes in the…”
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A specific radioimmunoassay for androstenedione with reduced bridge-binding by Nordblom, G D, Counsell, R E, England, B G

“…Antibody used in a steroid radioimmunoassay raised against a steroid hapten-carrier protein conjugate may recognize both the hapten and the chemical bridge to…”
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A chemical approach to solving bridging phenomena in steroid radioimmunoassays by Nordblom, G D, Webb, R, Counsell, R E, England, B G

“…Steroid radioimmunoassays (RIA) employ antibodies raised against a carrier protein-steroid conjugate. Individual antibodies may recognize the steroid, the…”
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Elucidation of peptide metabolism by on-line immunoaffinity liquid chromatography mass spectrometry by Zheng, Kefei, Lubman, David M., Rossi, David T., Nordblom, Gerald D., Barksdale, Charles M.

“…An immunoaffinity chromatography extraction capillary liquid chromatography separation has been coupled to electrospray ionization mass spectrometry for…”
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