Search Results - "Nordberg, Agneta"

Alzheimer’s disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline by Bucci, Marco, Chiotis, Konstantinos, Nordberg, Agneta

“…For early detection of Alzheimer’s disease, it is important to find biomarkers with predictive value for disease progression and clinical manifestations, such…”
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Tau PET imaging in neurodegenerative tauopathies—still a challenge by Leuzy, Antoine, Chiotis, Konstantinos, Lemoine, Laetitia, Gillberg, Per-Göran, Almkvist, Ove, Rodriguez-Vieitez, Elena, Nordberg, Agneta

“…The accumulation of pathological misfolded tau is a feature common to a collective of neurodegenerative disorders known as tauopathies, of which Alzheimer’s…”
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Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer’s disease by Kumar, Amit, Fontana, Igor C., Nordberg, Agneta

“…Astrocytes are highly efficient homeostatic glial cells playing a crucial role in optimal brain functioning and homeostasis. Astrocytes respond to changes in…”
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Assessing synaptic integrity in Alzheimer’s brain with UCB‐J by Kumar, Amit, Nordberg, Agneta K

“…Background Synaptic loss is an eminent feature of Alzheimer’s disease (AD). Synapses critical for neuronal transmission are regulated by synaptic vesicles…”
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Longitudinal pathways of cerebrospinal fluid and positron emission tomography biomarkers of amyloid-β positivity by Sala, Arianna, Nordberg, Agneta, Rodriguez-Vieitez, Elena

“…Mismatch between CSF and PET amyloid-β biomarkers occurs in up to ≈20% of preclinical/prodromal Alzheimer’s disease individuals. Factors underlying mismatching…”
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Astroglial tracer BU99008 detects multiple binding sites in Alzheimer’s disease brain by Kumar, Amit, Koistinen, Niina A., Malarte, Mona-Lisa, Nennesmo, Inger, Ingelsson, Martin, Ghetti, Bernardino, Lemoine, Laetitia, Nordberg, Agneta

“…With reactive astrogliosis being established as one of the hallmarks of Alzheimer’s disease (AD), there is high interest in developing novel positron emission…”
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[18F]THK5317 imaging as a tool for predicting prospective cognitive decline in Alzheimer’s disease by Chiotis, Konstantinos, Savitcheva, Irina, Poulakis, Konstantinos, Saint-Aubert, Laure, Wall, Anders, Antoni, Gunnar, Nordberg, Agneta

“…Cross-sectional studies have indicated potential for positron emission tomography (PET) in imaging tau pathology in Alzheimer’s disease (AD); however, its…”
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Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria by Dubois, Bruno, Prof, Feldman, Howard H, Prof, Jacova, Claudia, PhD, Hampel, Harald, Prof, Molinuevo, José Luis, MD, Blennow, Kaj, MD, DeKosky, Steven T, Prof, Gauthier, Serge, Prof, Selkoe, Dennis, Prof, Bateman, Randall, MD, Cappa, Stefano, MD, Crutch, Sebastian, PhD, Engelborghs, Sebastiaan, MD, Frisoni, Giovanni B, Prof, Fox, Nick C, MD, Galasko, Douglas, Prof, Habert, Marie-Odile, MD, Jicha, Gregory A, MD, Nordberg, Agneta, MD, Pasquier, Florence, Prof, Rabinovici, Gil, MD, Robert, Philippe, Prof, Rowe, Christopher, MD, Salloway, Stephen, Prof, Sarazin, Marie, Prof, Epelbaum, Stéphane, MD, de Souza, Leonardo C, MD, Vellas, Bruno, Prof, Visser, Pieter J, MD, Schneider, Lon, Prof, Stern, Yaakov, Prof, Scheltens, Philip, Prof, Cummings, Jeffrey L, Prof

“…Summary In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging–Alzheimer's Association have contributed…”
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Characterization of MK6240, a tau PET tracer, in autopsy brain tissue from Alzheimer’s disease cases by Malarte, Mona-Lisa, Nordberg, Agneta, Lemoine, Laetitia

“…Purpose MK6240 is a second-generation tau PET tracer designed to detect the neurofibrillary tangles in the brains of patients with Alzheimer’s disease (AD)…”
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Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease by Rodriguez-Vieitez, Elena, Saint-Aubert, Laure, Carter, Stephen F, Almkvist, Ove, Farid, Karim, Schöll, Michael, Chiotis, Konstantinos, Thordardottir, Steinunn, Graff, Caroline, Wall, Anders, Långström, Bengt, Nordberg, Agneta

“…Alzheimer's disease is a multifactorial dementia disorder characterized by early amyloid-β, tau deposition, glial activation and neurodegeneration, where the…”
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Multi‐tracer comparison in Alzheimer’s disease, Corticobasal Degeneration and Progressive Supranuclear Palsy brains by Malarte, Mona‐Lisa, Kumar, Amit, Nordberg, Agneta K

“…Background Recent CryoEM studies in tauopathies clearly bought forward one more time the complexity of these pathologies, and showed that it goes beyond the…”
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Nicotinic receptor abnormalities of Alzheimer’s disease: therapeutic implications by Nordberg, Agneta

“…The neuronal nicotinic acetylcholine receptors (nAChRs) in the brain are important for functional processes, including cognitive and memory functions. The…”
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Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG by Carter, Stephen F, Schöll, Michael, Almkvist, Ove, Wall, Anders, Engler, Henry, Långström, Bengt, Nordberg, Agneta

“…Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer disease (AD) brain tissue. It is therefore of great interest to develop a…”
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SNMMI Procedure Standard/EANM Practice Guideline for Amyloid PET Imaging of the Brain 1.0 by Minoshima, Satoshi, Drzezga, Alexander E, Barthel, Henryk, Bohnen, Nicolaas, Djekidel, Mehdi, Lewis, David H, Mathis, Chester A, McConathy, Jonathan, Nordberg, Agneta, Sabri, Osama, Seibyl, John P, Stokes, Margaret K, Van Laere, Koen

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Clinical validity of second-generation tau PET tracers as biomarkers for Alzheimer’s disease in the context of a structured 5-phase development framework by Bischof, Gérard N, Dodich, Alessandra, Boccardi, Marina, van Eimeren, Thilo, Festari, Cristina, Barthel, Henryk, Hansson, Oskar, Nordberg, Agneta, Ossenkoppele, Rik, Sabri, Osama, Giovanni, B Frisoni G, Garibotto, Valentina, Drzezga, Alexander

“…Purpose In 2017, the Geneva Alzheimer’s disease (AD) strategic biomarker roadmap initiative proposed a framework of the systematic validation AD biomarkers to…”
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Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease by NORDBERG, Agneta

“…Inhibitors of the enzyme acetylcholinesterase (AChE) are presently used as long-term symptomatic treatments for patients with Alzheimer disease (AD), as they…”
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Clinical validity of brain fluorodeoxyglucose positron emission tomography as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework by Garibotto, Valentina, Herholz, Karl, Boccardi, Marina, Picco, Agnese, Varrone, Andrea, Nordberg, Agneta, Nobili, Flavio, Ratib, Osman

“…Abstract The use of Alzheimer's disease (AD) biomarkers is supported in diagnostic criteria, but their maturity for clinical routine is still debated. Here, we…”
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A biomarker-validated time scale in years of disease progression has identified early- and late-onset subgroups in sporadic Alzheimer's disease by Almkvist, Ove, Nordberg, Agneta

“…It is possible to calculate the number of years to the expected clinical onset (YECO) of autosomal-dominant Alzheimer's disease (adAD). A similar time scale is…”
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Longitudinal association between astrocyte function and glucose metabolism in autosomal dominant Alzheimer’s disease by Carter, Stephen F., Chiotis, Konstantinos, Nordberg, Agneta, Rodriguez-Vieitez, Elena

“…Purpose The spatial resolution of 18 F-fluorodeoxyglucose PET does not allow the specific cellular origin of its signal to be determined, but it is commonly…”
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Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies by Ono, Maiko, Sahara, Naruhiko, Kumata, Katsushi, Ji, Bin, Ni, Ruiqing, Koga, Shunsuke, Dickson, Dennis W, Trojanowski, John Q, Lee, Virginia M-Y, Yoshida, Mari, Hozumi, Isao, Yoshiyama, Yasumasa, van Swieten, John C, Nordberg, Agneta, Suhara, Tetsuya, Zhang, Ming-Rong, Higuchi, Makoto

“…Diverse neurodegenerative disorders are characterized by deposition of tau fibrils composed of conformers (i.e. strains) unique to each illness. The…”
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