Search Results - "Norcross, Stevie"
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Toward newborn screening of metachromatic leukodystrophy: results from analysis of over 27,000 newborn dried blood spots
Published in Genetics in medicine (01-03-2021)“…Purpose Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by the deficiency of arylsulfatase A (ARSA), which results in the…”
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Journal Article -
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Methods and feasibility study for exome sequencing as a universal second-tier test in newborn screening
Published in Genetics in medicine (01-04-2021)“…Newborn screening disorders increasingly require genetic variant analysis as part of second-tier or confirmatory testing. Sanger sequencing and gene-specific…”
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Journal Article -
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pH- and Temperature-Dependent Peptide Binding to the Lactococcus lactis Oligopeptide-Binding Protein A Measured with a Fluorescence Anisotropy Assay
Published in ACS omega (28-02-2019)“…Bacterial ATP-binding cassette transporters are a superfamily of transport systems involved in the import of various molecules including amino acids, ions,…”
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Engineering Genetically Encoded Fluorescent Biosensors to Study the Role of Mitochondrial Dysfunction and Inflammation in Parkinson’s Disease
Published 01-01-2019“…Parkinson’s disease is a neurodegenerative disorder characterized by a loss of dopaminergic neurons, where mitochondrial dysfunction and neuroinflammation are…”
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Dissertation -
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Constructing Red‐Shifted Fluorescent Protein Sensors of Cellular Redox Status
Published in The FASEB journal (01-04-2017)“…Abstract only Redox status, which can vary over time and across subcellular compartments, is an important indicator of cell activity and health. Fluorescent…”
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Journal Article -
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Neuron Activity Dependent Redox Compartmentation Revealed with a Second Generation Red-Shifted Ratiometric Sensor
Published in ACS chemical neuroscience (02-09-2020)“…Oxidative stress is a hallmark of several aging and trauma related neurological disorders, but the precise details of how altered neuronal activity elicits…”
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Journal Article -
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Extending roGFP Emission via Förster-Type Resonance Energy Transfer Relay Enables Simultaneous Dual Compartment Ratiometric Redox Imaging in Live Cells
Published in ACS sensors (22-11-2017)“…Reactive oxygen species (ROS) mediate both intercellular and intraorganellar signaling, and ROS propagate oxidative stress between cellular compartments such…”
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Journal Article -
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Extending roGFP Emission via Förster-Type Resonance Energy Transfer Relay Enables Simultaneous Dual Compartment Ratiometric Redox Imaging in Live Cells
Published in ACS sensors (22-11-2017)“…Reactive oxygen species (ROS) mediate both intercellular and intraorganellar signaling, and ROS propagate oxidative stress between cellular compartments such…”
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Journal Article -
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Extending roGFP Emission via FRET Relay Enables Simultaneous Dual Compartment Ratiometric Redox Imaging in Live Cells
Published in ACS sensors (07-11-2017)“…Reactive oxygen species (ROS) mediate both intercellular and intraorganellar signaling, and ROS propagate oxidative stress between cellular compartments such…”
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Journal Article