Search Results - "Norbury, Luke J"

The Role of Nuclear Factor Kappa B (NF-κB) in the Immune Response against Parasites by Bąska, Piotr, Norbury, Luke J

“…The immune system consists of various cells, organs, and processes that interact in a sophisticated manner to defend against pathogens. Upon initial exposure…”
Get full text

Praziquantel use in aquaculture – Current status and emerging issues by Norbury, Luke J., Shirakashi, Sho, Power, Cecilia, Nowak, Barbara F., Bott, Nathan J.

“…Parasitic diseases are major constraints in fish mariculture. The anthelmintic praziquantel (PZQ) can effectively treat a range of flatworm parasites in a…”
Get full text

Pathogenesis of Anemia in Canine Babesiosis: Possible Contribution of Pro-Inflammatory Cytokines and Chemokines-A Review by Zygner, Wojciech, Gójska-Zygner, Olga, Norbury, Luke J

“…Canine babesiosis is a tick-borne protozoan disease caused by intraerythrocytic parasites of the genus . The infection may lead to anemia in infected dogs…”
Get full text

Changes in Erythrocytes in 88 Hyperthyroid Cats by Gójska-Zygner, Olga, Kotomski, Grzegorz, Gajger, Joanna, Norbury, Luke J, Zygner, Wojciech

“…Background: There is only a limited number of studies that show alterations in erythrocytes in feline hyperthyroidism. Discrepancies between the findings of…”
Get full text

Canine Babesiosis Caused by Large Babesia Species: Global Prevalence and Risk Factors—A Review by Zygner, Wojciech, Gójska-Zygner, Olga, Bartosik, Justyna, Górski, Paweł, Karabowicz, Justyna, Kotomski, Grzegorz, Norbury, Luke J.

“…Canine babesiosis is a disease caused by protozoan pathogens belonging to the genus Babesia. Four species of large Babesia cause canine babesiosis (B. canis,…”
Get full text

Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell Polarization by Promoting Dendritic Cell Thrombospondin-1 Secretion Without Affecting Metabolic Homeostasis in Obese Mice by Zawistowska-Deniziak, Anna, Lambooij, Joost M, Kalinowska, Alicja, Patente, Thiago A, Łapiński, Maciej, van der Zande, Hendrik J P, Basałaj, Katarzyna, de Korne, Clarize M, Chayé, Mathilde A M, Gasan, Thomas A, Norbury, Luke J, Giera, Martin, Zaldumbide, Arnaud, Smits, Hermelijn H, Guigas, Bruno

“…The parasitic trematode evades host immune defenses through secretion of various immunomodulatory molecules. Fatty Acid Binding Proteins ( FABPs) are among the…”
Get full text

Lymphocyte responses of rats vaccinated with cDNA encoding a phosphoglycerate kinase of Fasciola hepatica (FhPGK) and F. hepatica infection by Wesołowska, Agnieszka, Zawistowska-Deniziak, Anna, Norbury, Luke J, Wilkowski, Przemysław, Pyziel, Anna M, Zygner, Wojciech, Wędrychowicz, Halina

“…Abstract Lymphocyte responses in the blood, peritoneal fluid and both mesenteric and hepatic lymph nodes of cDNA-FhPGK/pCMV vaccinated and/or Fasciola hepatica…”
Get full text

Vaccination against Fasciola hepatica using cathepsin L3 and B3 proteases delivered alone or in combination by Wesołowska, Agnieszka, Basałaj, Katarzyna, Norbury, Luke J, Sielicka, Alicja, Wędrychowicz, Halina, Zawistowska-Deniziak, Anna

“…•Fasciola hepatica juvenile-specific cathepsins are viable vaccine targets.•FhCL3-2 vaccine induced the highest protection of 63 % in rats.•Trivalently…”
Get full text

Intranasal delivery of a formulation containing stage-specific recombinant proteins of Fasciola hepatica cathepsin L5 and cathepsin B2 triggers an anti-fecundity effect and an adjuvant-mediated reduction in fluke burden in sheep by Norbury, Luke J., Basałaj, Katarzyna, Zawistowska-Deniziak, Anna, Sielicka, Alicja, Wilkowski, Przemysław, Wesołowska, Agnieszka, Smooker, Peter M., Wędrychowicz, Halina

“…[Display omitted] •Nasal delivery of a vaccine against Fasciola hepatica induced an anti-fecundity effect.•Nasal delivery of the vaccine elicited…”
Get full text

Generation of a single-chain variable fragment phage display antibody library from naïve mice panned against Fasciola hepatica antigens by Norbury, Luke J., Basałaj, Katarzyna, Bąska, Piotr, Zawistowska-Deniziak, Anna, Kalinowska, Alicja, Wilkowski, Przemysław, Wesołowska, Agnieszka, Wędrychowicz, Halina

“…Monoclonal antibodies have a wide range of applications in basic and applied research as well as in the medical and pharmaceutical industries. Phage display…”
Get full text

Sex and vaccination: Insights from female rats vaccinated with juvenile-specific proteases from Fasciola hepatica by Wesołowska, Agnieszka, Basałaj, Katarzyna, Norbury, Luke J., Sielicka, Alicja, Wędrychowicz, Halina, Zawistowska-Deniziak, Anna

“…•Sex-biased differences in vaccine efficacy were reported.•Vaccinated female rats were not protected from infection.•Reduction in wet weight was adjuvant not…”
Get full text

Construction of a novel phage display antibody library against Fasciola hepatica, and generation of a single-chain variable fragment specific for F. hepatica cathepsin L1 by Norbury, Luke J., Basałaj, Katarzyna, Bąska, Piotr, Kalinowska, Alicja, Zawistowska-Deniziak, Anna, Yap, Huan Yong, Wilkowski, Przemysław, Wesołowska, Agnieszka, Wędrychowicz, Halina

“…Phage display technology to produce recombinant monoclonal antibodies or antibody fragments permits the identification of sought after antibodies in short time…”
Get full text

Adult and juvenile Fasciola cathepsin L proteases: Different enzymes for different roles by Norbury, Luke J., Beckham, Simone, Pike, Robert N., Grams, Rudi, Spithill, Terry W., Fecondo, John V., Smooker, Peter M.

“…Cathepsin proteases are promising vaccine or drug targets for prophylaxis or therapy against Fasciola parasites which express cathepsin L and B proteases…”
Get full text

Immune responses in rats and sheep induced by a DNA vaccine containing the phosphoglycerate kinase gene of Fasciola hepatica and liver fluke infection by Wesołowska, Agnieszka, Zawistowska-Deniziak, Anna, Norbury, Luke J., Wilkowski, Przemysław, Januszkiewicz, Kamil, Pyziel, Anna M., Zygner, Wojciech, Wędrychowicz, Halina

“…Immune responses of rats and sheep following vaccination with cDNA encoding phosphoglycerate kinase of Fasciola hepatica (cDNA-FhPGK/pCMV) and F. hepatica…”
Get full text

Microarray analysis of rat immune responses to liver fluke infection following vaccination with Fasciola hepatica phosphoglycerate kinase by Wesołowska, Agnieszka, Jaros, Sławomir, Norbury, Luke J., Jaros, Dorota, Zygner, Wojciech, Wędrychowicz, Halina

“…[Display omitted] ► Rats were vaccinated with FhPGK and infected with F. hepatica. ► Rat immune response was analyzed using microarray. ► Expression levels of…”
Get full text

Dictyocaulosis in dairy cows in Brazil: an epidemiological, clinical-pathological and therapeutic approach by Henker, Luan C., Schwertz, Claiton I., Lucca, Neuber J., Piva, Manoela M., Giacomin, Patricia, Gris, Anderson, Rhoden, Leandro A., Norbury, Luke J., da Silva, Aleksandro S., da Rosa, Rafael A., Mendes, Ricardo E.

“…An outbreak of severe parasitic pneumonia caused by Dictyocaulus viviparus was diagnosed in adult dairy cows in the municipality of Arabutã, Southern Brazil…”
Get full text

Excretory/secretory products of Fasciola hepatica but not recombinant phosphoglycerate kinase induce death of human hepatocyte cells by Bąska, Piotr, Norbury, Luke J., Wiśniewski, Marcin, Januszkiewicz, Kamil, Wędrychowicz, Halina

“…The liver fluke Fasciola hepatica infects a wide range of hosts, and has a considerable impact on the agriculture industry, mainly through infections of sheep…”
Get full text

Variations in cercarial production and the level of in vitro activation of metacercariae of two different isolates of Fasciola hepatica by Januszkiewicz, Kamil, Norbury, Luke J., Wilkowski, Przemysław, Zawistowska-Deniziak, Anna, Wesołowska, Agnieszka, Wedrychowicz, Halina

“…Fasciola hepatica infections cause large economic losses and are a serious veterinary medicine problem in many regions of the world. Recent studies examining…”
Get full text

Evaluation of the immune response of male and female rats vaccinated with cDNA encoding a cysteine proteinase of Fasciola hepatica (FhPcW1) by Wesołowska, Agnieszka, Norbury, Luke J., Januszkiewicz, Kamil, Jedlina, Luiza, Jaros, Sławomir, Zawistowska-Deniziak, Anna, Zygner, Wojciech, Wędrychowicz, Halina

“…Not only do males and females of many species vary in their responses to certain parasitic infections, but also to treatments such as vaccines. However, there…”
Get full text

Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1–P4 specificity reveals an unusual preference by Norbury, Luke J., Hung, Andrew, Beckham, Simone, Pike, Robert N., Spithill, Terry W., Craik, Charles S., Choe, Youngchool, Fecondo, John V., Smooker, Peter M.

“…Fasciola parasites (liver flukes) express numerous cathepsin L proteases that are believed to be involved in important functions related to host invasion and…”
Get full text