Search Results - "Norbert, Garnier"

Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing by Franck, Coste, Stéphane, Goffinont, Julien, Cros, Virginie, Gaudon, Martine, Guérin, Norbert, Garnier, Fabrice, Confalonieri, Didier, Flament, Josef, Suskiewicz Marcin, Bertrand, Castaing

“…8-Oxoguanine (GO) is a major purine oxidation product in DNA. Because of its highly mutagenic properties, GO absolutely must be eliminated from DNA. To do…”
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Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights by Rieux, Charlotte, Goffinont, Stéphane, Coste, Franck, Tber, Zahira, Cros, Julien, Roy, Vincent, Guérin, Martine, Gaudon, Virginie, Bourg, Stéphane, Biela, Artur, Aucagne, Vincent, Agrofoglio, Luigi, Garnier, Norbert, Castaing, Bertrand

“…DNA glycosylases are emerging as relevant pharmacological targets in inflammation, cancer and neurodegenerative diseases. Consequently, the search for…”
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Transmembrane recognition of the semaphorin co-receptors neuropilin 1 and plexin A1: coarse-grained simulations by Aci-Sèche, Samia, Sawma, Paul, Hubert, Pierre, Sturgis, James N, Bagnard, Dominique, Jacob, Laurent, Genest, Monique, Garnier, Norbert

“…The cancer associated class 3 semaphorins require direct binding to neuropilins and association to plexins to trigger cell signaling. Here, we address the role…”
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Transmembrane Domain Targeting Peptide Antagonizing ErbB2/Neu Inhibits Breast Tumor Growth and Metastasis by Arpel, Alexia, Sawma, Paul, Spenlé, Caroline, Fritz, Justine, Meyer, Lionel, Garnier, Norbert, Velázquez-Quesada, Inés, Hussenet, Thomas, Aci-Sèche, Samia, Baumlin, Nadège, Genest, Monique, Brasse, David, Hubert, Pierre, Crémel, Gérard, Orend, Gertraud, Laquerrière, Patrice, Bagnard, Dominique

“…Breast cancer is still a deadly disease despite major achievements in targeted therapies designed to block ligands or ligand-binding subunits of major tyrosine…”
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Molecular dynamics simulation approach for the prediction of transmembrane helix-helix heterodimers assembly by Samna Soumana, Oumarou, Garnier, Norbert, Genest, Monique

“…Computational methods are useful to identify favorable structures of transmembrane (TM) helix oligomers when experimental data are not available or when they…”
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Insight into the recognition patterns of the ErbB receptor family transmembrane domains: heterodimerization models through molecular dynamics search by Samna Soumana, Oumarou, Garnier, Norbert, Genest, Monique

“…ErbB receptors undergo a complex interaction network defining hierarchical and competition relationships. Dimerization is driven entirely by receptor–receptor…”
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Residence Time Prediction of Type 1 and 2 Kinase Inhibitors from Unbinding Simulations by Braka, Abdennour, Garnier, Norbert, Bonnet, Pascal, Aci-Sèche, Samia

“…In the early stage of a drug discovery process, the selection and optimization of a ligand is mainly based on equilibrium thermodynamic constants such as K D…”
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Structural insights into the regulation of the human E2∼SUMO conjugate through analysis of its stable mimetic by Goffinont, Stéphane, Coste, Franck, Prieu-Serandon, Pierre, Mance, Lucija, Gaudon, Virginie, Garnier, Norbert, Castaing, Bertrand, Suskiewicz, Marcin Józef

“…Protein SUMOylation is a ubiquitylation-like post-translational modification (PTM) that is synthesized through an enzymatic cascade involving an E1…”
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Dynamic BTB-domain filaments promote clustering of ZBTB proteins by Mance, Lucija, Bigot, Nicolas, Zhamungui Sánchez, Edison, Coste, Franck, Martín-González, Natalia, Zentout, Siham, Biliškov, Marin, Pukało, Zofia, Mishra, Aanchal, Chapuis, Catherine, Arteni, Ana-Andreea, Lateur, Axelle, Goffinont, Stéphane, Gaudon, Virginie, Talhaoui, Ibtissam, Casuso, Ignacio, Beaufour, Martine, Garnier, Norbert, Artzner, Franck, Cadene, Martine, Huet, Sébastien, Castaing, Bertrand, Suskiewicz, Marcin Józef

“…The formation of dynamic protein filaments contributes to various biological functions by clustering individual molecules together and enhancing their binding…”
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Peptide-Conjugated MRI Probe Targeted to Netrin-1, a Novel Metastatic Breast Cancer Biomarker by Moreau, Clémentine, Lukačević, Tea, Pallier, Agnès, Sobilo, Julien, Aci-Sèche, Samia, Garnier, Norbert, Même, Sandra, Tóth, Éva, Lacerda, Sara

“…Despite significant progress in cancer imaging and treatment over the years, early diagnosis and metastasis detection remain a challenge. Molecular magnetic…”
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Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane domain targeting peptide by Jacob, Laurent, Sawma, Paul, Garnier, Norbert, Meyer, Lionel A T, Fritz, Justine, Hussenet, Thomas, Spenlé, Caroline, Goetz, Jacky, Vermot, Julien, Fernandez, Aurore, Baumlin, Nadège, Aci-Sèche, Samia, Orend, Gertraud, Roussel, Guy, Crémel, Gérard, Genest, Monique, Hubert, Pierre, Bagnard, Dominique

“…The neuropilin-plexin receptor complex regulates tumor cell migration and proliferation and thus is an interesting therapeutic target. High expression of…”
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Ligand entry pathways in the ligand binding domain of PPARγ receptor by Aci-Sèche, Samia, Genest, Monique, Garnier, Norbert

“…► Targeted molecular dynamics can drive the GW0072-PPARγ complex from an unbound form to the bound form. ► No energy barrier is observed during the entry…”
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The X-ray Structure of NccX from Cupriavidus metallidurans 31A Illustrates Potential Dangers of Detergent Solubilization When Generating and Interpreting Crystal Structures of Membrane Proteins by Ziani, Widade, Maillard, Antoine P., Petit-Härtlein, Isabelle, Garnier, Norbert, Crouzy, Serge, Girard, Eric, Covès, Jacques

“…The x-ray structure of NccX, a type II transmembrane metal sensor, from Cupriavidus metallidurans 31A has been determined at a resolution of 3.12 Å. This was…”
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The Addressing Fragment of Mitogaligin: First Insights into Functional and Structural Properties by Senille, Violette, Lelievre, Dominique, Paquet, Françoise, Garnier, Norbert, Lamb, Ned, Legrand, Alain, Delmas, Agnès F., Landon, Céline

“…Mitogaligin is a mitochondrion‐targeting protein involved in cell death. The sequence of the protein is unrelated to that of any known pro‐ or antiapoptotic…”
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An alternative flexible conformation of the E. coli HU beta(2) protein: structural, dynamics, and functional aspects by Garnier, Norbert, Loth, Karine, Coste, Franck, Augustyniak, Rafal, Nadan, Virginie, Damblon, Christian, Castaing, Bertrand

“…The histone-like HU protein is the major nucleoid-associated protein involved in the dynamics and structure of the bacterial chromosome. Under physiological…”
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Ligand-escape pathways from the ligand-binding domain of PPARγ receptor as probed by molecular dynamics simulations by Genest, D., Garnier, N., Arrault, A., Marot, C., Morin-Allory, L., Genest, M.

“…Conformational rearrangements of peroxysome proliferator activated receptor (PPARγ) ligand-binding domain (LBD) that accompany the release and binding of…”
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Transmembrane Helix Packing of ErbB/Neu Receptor in Membrane Environment: A Molecular Dynamics Study by Aller, Pierre, Garnier, Norbert, Genest, Monique

“…Dimerization or oligomerization of the ErbB/Neu receptors are necessary but not sufficient for initiation of receptor signaling. The two intracellular domains…”
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Insight into the recognition patterns of the ErbB receptor family transmembrane domains: heterodimerization models through MD search by Samna Soumana, Oumarou, Garnier, Norbert, Genest, Monique

“…ErbB receptors undergo a complex interaction network defining hierarchical and competition relationships. Dimerization is driven entirely by receptor–receptor…”
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alternative flexible conformation of the E. coli HUβ₂ protein: structural, dynamics, and functional aspects by Garnier, Norbert, Loth, Karine, Coste, Franck, Augustyniak, Rafal, Nadan, Virginie, Damblon, Christian, Castaing, Bertrand

“…The histone-like HU protein is the major nucleoid-associated protein involved in the dynamics and structure of the bacterial chromosome. Under physiological…”
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An alternative flexible conformation of the E. coli HU[beta]^sub 2^ protein: structural, dynamics, and functional aspects by Garnier, Norbert, Loth, Karine, Coste, Franck, Augustyniak, Rafal, Nadan, Virginie, Damblon, Christian, Castaing, Bertrand

“…The histone-like HU protein is the major nucleoid-associated protein involved in the dynamics and structure of the bacterial chromosome. Under physiological…”
Get full text