A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells

Dendritic cells form a system of highly efficient antigen-presenting cells. After capturing antigen in the periphery, they migrate to lymphoid organs where they present the antigen to T cells,. Their seemingly unique ability to interact with and sensitize naive T cells gives dendritic cells a centra...

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Bibliographic Details
Published in:	Nature (London) Vol. 387; no. 6634; pp. 713 - 717
Main Authors:	Adema, Gosse J, Hartgers, Franca, Verstraten, Riet, de Vries, Edwin, Marland, Gill, Menon, Satish, Foster, Jessica, Xu, Yuming, Nooyen, Pete, McClanahan, Terrill, Bacon, Kevin B, Figdor, Carl G
Format:	Journal Article
Language:	English
Published:	London Nature Publishing 12-06-1997 Nature Publishing Group
Subjects:	Amino Acid Sequence Analysis of the immune response. Humoral and cellular immunity Base Sequence Biological and medical sciences Cells, Cultured Cellular biology Chemokines - analysis Chemokines - genetics Chemokines - immunology Chemokines, CC Chemotaxis, Leukocyte Cloning, Molecular Dendritic Cells - chemistry Dendritic Cells - immunology DNA, Complementary Fundamental and applied biological sciences. Psychology Fundamental immunology Germinal Center - cytology Germinal Center - immunology Granulocyte-Macrophage Colony-Stimulating Factor - physiology Humans Immune response Immunity (Disease) Immunobiology In Situ Hybridization Interleukin-4 - physiology Leukocyte Common Antigens - immunology Lymphocyte Activation Lymphocytes Medical research Molecular Sequence Data Organs and cells involved in the immune response RNA, Messenger Sequence Homology, Amino Acid T-Lymphocyte Subsets - immunology Time Factors Chemokine Dendritic cell Antigen presentation Immune response Cytokine T-Lymphocyte Sensitization Biological activity Immune system
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Summary:	Dendritic cells form a system of highly efficient antigen-presenting cells. After capturing antigen in the periphery, they migrate to lymphoid organs where they present the antigen to T cells,. Their seemingly unique ability to interact with and sensitize naive T cells gives dendritic cells a central role in the initiation of immune responses and allows them to be used in therapeutic strategies against cancer, viral infection and other diseases. How they interact preferentially with naive rather than activated T lymphocytes is still poorly understood. Chemokines direct the transport of white blood cells in immune surveillance,. Here we report the identification and characterization of a C-C chemokine (DC-CK1) that is specifically expressed by human dendritic cells at high levels. Tissue distribution analysis demonstrates that dendritic cells present in germinal centres and T-cell areas of secondary lymphoid organs express this chemokine. We show that DC-CK1, in contrast to RANTES, MIP-1α and interleukin-8, preferentially attracts naive T cells (CD45RA+). The specific expression of DC-CK1 by dendritic cells at the site of initiation of an immune response, combined with its chemotactic activity for naive T cells, suggests that DC-CK1 has an important rule in the induction of immune responses.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0028-0836 1476-4687
DOI:	10.1038/42716