Search Results - "Noothi, Sunil K."

Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction by Sreejit, Gopalkrishna, Abdel-Latif, Ahmed, Athmanathan, Baskaran, Annabathula, Rahul, Dhyani, Ashish, Noothi, Sunil K., Quaife-Ryan, Gregory A., Al-Sharea, Annas, Pernes, Gerard, Dragoljevic, Dragana, Lal, Hind, Schroder, Kate, Hanaoka, Beatriz Y., Raman, Chander, Grant, Maria B., Hudson, James E., Smyth, Susan S., Porrello, Enzo R., Murphy, Andrew J., Nagareddy, Prabhakara R.

“…BACKGROUND:Myocardial infarction (MI) triggers myelopoiesis, resulting in heightened production of neutrophils. However, the mechanisms that sustain their…”
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Residual risks and evolving atherosclerotic plaques by Noothi, Sunil K., Ahmed, Mohamed Radwan, Agrawal, Devendra K.

“…Atherosclerotic disease of the coronary and carotid arteries is the primary global cause of significant mortality and morbidity. The chronic occlusive diseases…”
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Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 Deficiency by Duan, Yaqian, Prasad, Ram, Feng, Dongni, Beli, Eleni, Li Calzi, Sergio, Longhini, Ana Leda F, Lamendella, Regina, Floyd, Jason L, Dupont, Mariana, Noothi, Sunil K, Sreejit, Gopalkrishna, Athmanathan, Baskaran, Wright, Justin, Jensen, Amanda R, Oudit, Gavin Y, Markel, Troy A, Nagareddy, Prabhakara R, Obukhov, Alexander G, Grant, Maria B

“…RATIONALE:There is incomplete knowledge of the impact of bone marrow cells on the gut microbiome and gut barrier function. OBJECTIVE:We postulated that…”
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Chronic Lymphocytic Leukemia-Derived IL-10 Suppresses Antitumor Immunity by Alhakeem, Sara S, McKenna, Mary K, Oben, Karine Z, Noothi, Sunil K, Rivas, Jacqueline R, Hildebrandt, Gerhard C, Fleischman, Roger A, Rangnekar, Vivek M, Muthusamy, Natarajan, Bondada, Subbarao

“…Chronic lymphocytic leukemia (CLL) patients progressively develop an immunosuppressive state. CLL patients have more plasma IL-10, an anti-inflammatory…”
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Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis by Burikhanov, Ravshan, Hebbar, Nikhil, Noothi, Sunil K., Shukla, Nidhi, Sledziona, James, Araujo, Nathália, Kudrimoti, Meghana, Wang, Qing Jun, Watt, David S., Welch, Danny R., Maranchie, Jodi, Harada, Akihiro, Rangnekar, Vivek M.

“…The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report…”
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It's reticulated: the liver at the heart of atherosclerosis by Nagareddy, Prabhakara R, Noothi, Sunil K, Flynn, Michelle C, Murphy, Andrew J

“…Platelets play a critical role in both the initiation and progression of atherosclerosis, and even more so in the ensuing atherothrombotic complications…”
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Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes by Asare-Bediako, Bright, Noothi, Sunil K, Li Calzi, Sergio, Athmanathan, Baskaran, Vieira, Cristiano P, Adu-Agyeiwaah, Yvonne, Dupont, Mariana, Jones, Bryce A, Wang, Xiaoxin X, Chakraborty, Dibyendu, Levi, Moshe, Nagareddy, Prabhakara R, Grant, Maria B

“…We sought to delineate the retinal features associated with the high-fat diet (HFD) mouse, a widely used model of obesity. C57BL/6 mice were fed either a…”
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Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity by Araujo, Nathalia, Sledziona, James, Noothi, Sunil K, Burikhanov, Ravshan, Hebbar, Nikhil, Ganguly, Saptadwipa, Shrestha-Bhattarai, Tripti, Zhu, Beibei, Katz, Wendy S, Zhang, Yi, Taylor, Barry S, Liu, Jinze, Chen, Li, Weiss, Heidi L, He, Daheng, Wang, Chi, Morris, Andrew J, Cassis, Lisa A, Nikolova-Karakashian, Mariana, Nagareddy, Prabhakar R, Melander, Olle, Evers, B Mark, Kern, Philip A, Rangnekar, Vivek M

“…Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains…”
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Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma by Potluri, Veena, Noothi, Sunil K, Vallabhapurapu, Subrahmanya D, Yoon, Sang-Oh, Driscoll, James J, Lawrie, Charles H, Vallabhapurapu, Sivakumar

“…Multiple Myeloma (MM) is an incurable plasma cell cancer that is caused by several chromosomal translocations and gene deletions. Although deregulation of…”
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Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A by Oben, Karine Z, Alhakeem, Sara S, McKenna, Mary K, Brandon, Jason A, Mani, Rajeswaran, Noothi, Sunil K, Jinpeng, Liu, Akunuru, Shailaja, Dhar, Sanjit K, Singh, Inder P, Liang, Ying, Wang, Chi, Abdel-Latif, Ahmed, Stills, Jr, Harold F, St Clair, Daret K, Geiger, Hartmut, Muthusamy, Natarajan, Tohyama, Kaoru, Gupta, Ramesh C, Bondada, Subbarao

“…Myelodysplastic syndromes (MDS) are a diverse group of malignant clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis,…”
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Transcriptional repression by the HDAC4–RelB–p52 complex regulates multiple myeloma survival and growth by Vallabhapurapu, Subrahmanya D., Noothi, Sunil K., Pullum, Derek A., Lawrie, Charles H., Pallapati, Rachel, Potluri, Veena, Kuntzen, Christian, Khan, Sohaib, Plas, David R., Orlowski, Robert Z., Chesi, Marta, Kuehl, W. Michael, Bergsagel, P. Leif, Karin, Michael, Vallabhapurapu, Sivakumar

“…Although transcriptional activation by NF-κB is well appreciated, physiological importance of transcriptional repression by NF-κB in cancer has remained…”
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Role of the splenic microenvironment in chronic lymphocytic leukemia development in Eµ-TCL1 transgenic mice by Collard, James P., McKenna, Mary K., Noothi, Sunil K., Alhakeem, Sara S., Rivas, Jacqueline R., Rangnekar, Vivek M., Muthusamy, Natarajan, Bondada, Subbarao

“…The chronic lymphocytic leukemia (CLL) microenvironment has been receiving an increasing amount of attention, but there is currently limited data surrounding…”
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Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemia by McKenna, Mary K., Noothi, Sunil K., Alhakeem, Sara S., Oben, Karine Z., Greene, Joseph T., Mani, Rajeswaran, Perry, Kathryn L., Collard, James P., Rivas, Jacqueline R., Hildebrandt, Gerhard C., Fleischman, Roger A., Durbin, Eric B., Byrd, John C., Wang, Chi, Muthusamy, Natarajan, Rangnekar, Vivek M., Bondada, Subbarao

“…Prostate apoptosis response-4 (Par-4), a proapoptotic tumor suppressor protein, is downregulated in many cancers including renal cell carcinoma, glioblastoma,…”
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MutS and UvrD Proteins Stimulate Exonuclease Action: Insights into Exonuclease-Mediated Strand Repair by Noothi, Sunil K, Minda, Renu, Rao, Basuthkar J

“…MutS and UvrD proteins individually stimulate Escherichia coli exonuclease VII activity on blunt-ended short duplex DNA substrates. Stimulation by both…”
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Enhanced DNA dynamics due to cationic reagents, topological states of dsDNA and high mobility group box 1 as probed by PicoGreen by Noothi, Sunil K, Kombrabail, Mamata, Kundu, Tapas K, Krishnamoorthy, G, Rao, Basuthkar J

“…We report a study of dynamics with a dsDNA-specific dye called PicoGreen bound to plasmid DNA (3.4 kb), and show that at low dye/DNA phosphate ratios (1 : 100…”
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Fluorescence Characterization of the Structural Heterogeneity of Polytene Chromosomes by Noothi, Sunil K., Kombrabail, Mamata, Rao, Basuthkar J., Krishnamoorthy, G.

“…Studies on the physical nature of the structural heterogeneity of chromatin in their native states are few. The eukaryotic chromatin as observed by dye…”
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The role of the splenic microenvironment in Chronic Lymphocytic Leukemia by Bondada, Subbarao, Collard, James P., McKenna, Mary Kathryn, Noothi, Sunil K., Alhakeem, Sara S., Rivas, Jacqueline R., Broeking, Shelbi

“…Abstract Chronic Lymphocytic Leukemia (CLL), the most prevalent adult leukemia, is characterized by the clonal expansion of CD5+ CD19+ B cells within lymphoid…”
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Splenic microenvironment is important in the survival and growth of Chronic Lymphocytic Leukemia in mice by McKenna, Mary Kathryn, Noothi, Sunil K, Alhakeem, Sara Samir, Byrd, John C, Muthusamy, Natarajan, Rangnekar, Vivek, Bondada, Subbarao

“…Abstract Chronic Lymphocytic Leukemia (CLL), the most common adult leukemia in the western world, is characterized by accumulation of clonally expanded…”
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Chronic lymphocytic leukemia derived interleukin-10 suppresses anti-tumor immunity by Alhakeem, Sara S., McKenna, Mary K., Oben, Karine Z., Noothi, Sunil K., Rivas, Jacqueline R., Hildebrandt, Gerhard C., Fleischman, Roger A., Rangnekar, Vivek M., Muthusamy, Natarajan, Bondada, Subbarao

“…Chronic lymphocytic leukemia (CLL) patients progressively develop an immunosuppressive state. CLL patients have more plasma inerleukin-10 (IL-10), an…”
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Neutrophil-derived S100A8/A9 amplify granulopoiesis following myocardial infarction by Sreejit, Gopalkrishna, Abdel-Latif, Ahmed, Athmanathan, Baskaran, Annabathula, Rahul, Dhyani, Ashish, Noothi, Sunil K, Quaife-Ryan, Gregory A., Al-Sharea, Annas, Pernes, Gerard, Dragoljevic, Dragana, Lal, Hind, Schroder, Kate, Hanaoka, Beatriz Y, Raman, Chander, Grant, Maria B, Hudson, James E., Smyth, Susan, Porrello, Enzo R., Murphy, Andrew J., Nagareddy, Prabhakara R.

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