Search Results - "Noort, J. M."

Heat shock protein expression in cerebral X‐linked adrenoleukodystrophy reveals astrocyte stress prior to myelin loss by Görtz, A. L., Peferoen, L. A. N., Gerritsen, W. H., Noort, J. M., Bugiani, M., Amor, S.

“…Aims X‐linked adrenoleukodystrophy (X‐ALD) is a genetic white matter disorder in which demyelination occurs due to accumulation of very long‐chain fatty acids…”
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Rapidly progressive amyotrophic lateral sclerosis is associated with microglial reactivity and small heat shock protein expression in reactive astrocytes by Gorter, R. P., Stephenson, J., Nutma, E., Anink, J., Jonge, J. C., Baron, W., Jahreiβ, M.‐C., Belien, J. A. M., Noort, J. M., Mijnsbergen, C., Aronica, E., Amor, S.

“…Aims Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease characterized by progressive loss of motor neurons, muscle weakness,…”
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Heat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis by Gorter, R. P., Nutma, E., Jahrei, M.‐C., de Jonge, J. C., Quinlan, R. A, Valk, P., Noort, J. M., Baron, W., Amor, S.

“…Summary Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by demyelination, inflammation and neurodegeneration throughout the…”
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The impact of the involvement of a healthcare professional on the usage of an eHealth platform: a retrospective observational COPD study by van Zelst, Cathelijne M, Kasteleyn, Marise J, van Noort, Esther M J, Rutten-van Molken, Maureen P M H, Braunstahl, Gert-Jan, Chavannes, Niels H, In 't Veen, Johannes C C M

“…Ehealth platforms, since the outbreak of COVID-19 more important than ever, can support self-management in patients with Chronic Obstructive Pulmonary Disease…”
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Stress proteins in CNS inflammation by van Noort, JM

“…Stress proteins or heat shock proteins (HSPs) are ubiquitous cellular components that have long been known to act as molecular chaperones. By assisting proper…”
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Selective association of multiple sclerosis with infectious mononucleosis by Zaadstra, BM, Chorus, AMJ, van Buuren, S., Kalsbeek, H., van Noort, JM

“…Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this…”
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High-Resolution Observations of Fast Events in the Solar Chromosphere by van Noort, M. J, van der Voort, L. H. M. Rouppe

“…We present new, high spatial and high temporal resolution observations of the Sun in Ha obtained with the Swedish 1 m Solar Telescope on La Palma. The combined…”
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Autoantibodies against alpha B-crystallin, a candidate autoantigen in multiple sclerosis, are part of a normal human immune repertoire by van Noort, J M, Verbeek, R, Meilof, J F, Polman, C H, Amor, S

“…Human T-cell responses to the stress protein alpha B-crystallin in multiple sclerosis (MS)-affected brain samples are dominant when compared to other myelin…”
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Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE by Dijkstra, S, Kooij, G, Verbeek, R, van der Pol, S.M.A, Amor, S, Geisert, E.E, Dijkstra, C.D, van Noort, J.M, Vries, H.E. de

“…Abstract Leukocyte infiltration is a key step in the development of demyelinating lesions in multiple sclerosis (MS), and molecules mediating…”
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PECAM-1 and gelatinase B coexist in vascular cuffs of multiple sclerosis lesions by Nelissen, I., Gveric, D., Van Noort, J. M., Cuzner, M. L., Opdenakker, G.

“…In multiple sclerosis (MS), the matrix metalloprotease (MMP) gelatinase B/MMP‐9 and platelet endothelial cell adhesion molecule (PECAM)‐1 have both been…”
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S-layer protein of Lactobacillus acidophilus ATCC 4356: purification, expression in Escherichia coli, and nucleotide sequence of the corresponding gene by BOOT, H. J, KOLEN, C. P. A. M, VAN NOORT, J. M, POUWELS, P. H

“…The cell surfaces of several Lactobacillus species are covered by a regular layer composed of a single species of protein, the S-protein. The 43-kDa S-protein…”
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Genetic analysis of acidocin B, a novel bacteriocin produced by Lactobacillus acidophilus by Leer, Rob J, van der Vossen, Jos M. B. M, van Giezen, Mariska, van Noort Johannes, M, Pouwels, Peter H

“…1 TNO Nutrition and Food Research Institute, Department of Molecular Genetics and Gene-technology, PO Box 5815, 2280 HV Rijswijk, The Netherlands 2 Department…”
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Multiple sclerosis : an altered immune response or an altered stress response ? by VAN NOORT, J. M

“…The pathogenesis of multiple sclerosis (MS), the major neurological disease of young adults in the Western world, is still poorly understood, and no effective…”
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The selectivity of Cathepsin D Suggests an Involvement of the Enzyme in the Generation of T-cell Epitopes by van Noort, J M, van der Drift, A C

“…The selectivity of cathepsin D, a mammalian intracellular aspartyl proteinase involved in the degradation of endocytosed proteins, was studied. For this…”
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Broad Expression of Toll-Like Receptors in the Human Central Nervous System by BSIBSI, MALIKA, RAVID, RIVKA, GVERIC, DJORDJE, VAN NOORT, JOHANNES M

“…The family of Toll-like receptors (TLRs) plays a key role in controlling innate immune responses to a wide variety of pathogen-associated molecules. In this…”
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Space-time clustering of multiple sclerosis cases around birth by van Buuren, S., Zaadstra, B. M., Zwanikken, C. P., Buljevac, D., van Noort, J. M.

“…Objectives – To investigate whether infectious events around birth and during early infancy are likely to be of relevance in MS pathogenesis. Subjects and…”
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Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis by Robinson, William H, Fontoura, Paulo, Lee, Byung J, de Vegvar, Henry E Neuman, Tom, Jennifer, Pedotti, Rosetta, DiGennaro, Carla D, Mitchell, Dennis J, Fong, Derek, Ho, Peggy P-K, Ruiz, Pedro J, Maverakis, Emanual, Stevens, David B, Bernard, Claude C A, Martin, Roland, Kuchroo, Vijay K, van Noort, Johannes M, Genain, Claude P, Amor, Sandra, Olsson, Tomas, Utz, Paul J, Garren, Hideki, Steinman, Lawrence

“…The diversity of autoimmune responses poses a formidable challenge to the development of antigen-specific tolerizing therapy. We developed 'myelin proteome'…”
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Antigen processing by endosomal proteases determines which sites of sperm-whale myoglobin are eventually recognized by T cells by Van Noort, J M, Boon, J, Van der Drift, A C, Wagenaar, J P, Boots, A M, Boog, C J

“…This study reports an identification of the major processing products of an exogenous protein antigen, viz, sperm-whale myoglobin, as obtained after cell-free…”
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The small heat shock protein alpha B-crystallin as key autoantigen in multiple sclerosis by Van Noort, J M, van Sechel, A C, van Stipdonk, M J, Bajramovic, J J

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Purification of the stress protein αB-crystallin and its differentially phosphorylated forms by van Noort, Johannes M, van Veelen, Peter, Hopstaken, Frank

“…The stress protein αB-crystallin was recently identified as a component of central nervous system myelin that is strongly immunogenic to human T cells…”
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