Search Results - "Noorchashm, H"

B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice by Noorchashm, H., Noorchashm, N., Kern, J., Rostami, S. Y., Barker, C. F., Naji, A.

“…B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice. H Noorchashm , N Noorchashm , J Kern , S Y Rostami , C F Barker…”
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Sustained reduction of alloantibody secreting plasma cells and donor specific antibody with proteasome inhibition in mice by Redfield, R.R, Lou, Y, Rodriguez, E, Rostami, S, Parsons, R.F, Noorchashm, H, Naji, A, Abt, P.L

“…Abstract The long-lived plasma cells, which develop after alloantigen sensitization, produce donor specific alloantibodies (DSAs) that generate a positive…”
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Impaired Activation of Islet-Reactive CD4 T Cells in Pancreatic Lymph Nodes of B Cell-Deficient Nonobese Diabetic Mice by Greeley, Siri Atma W, Moore, Daniel J, Noorchashm, Hooman, Noto, Lauren E, Rostami, Susan Y, Schlachterman, Alexander, Song, Howard K, Koeberlein, Brigitte, Barker, Clyde F, Naji, Ali

“…Despite the impressive protection of B cell-deficient (muMT(-/-)) nonobese diabetic (NOD) mice from spontaneous diabetes, existence of mild pancreatic islet…”
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Impaired CD4 T Cell Activation Due to Reliance Upon B Cell-Mediated Costimulation in Nonobese Diabetic (NOD) Mice by Noorchashm, Hooman, Moore, Daniel J, Noto, Lauren E, Noorchashm, Negin, Reed, Amy J, Reed, Alison L, Song, Howard K, Mozaffari, Reza, Jevnikar, Anthony M, Barker, Clyde F, Naji, Ali

“…Diabetes in nonobese diabetic (NOD) mice results from the activation of I-A(g7)-restricted, islet-reactive T cells. This study delineates several…”
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Immunology of IDDM by NOORCHASHM, H, KWOK, W, RABINOVITCH, A, HARRISON, L. C

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Cutting Edge: Alloimmune Responses Against Major and Minor Histocompatibility Antigens: Distinct Division Kinetics and Requirement for CD28 Costimulation by Song, Howard K, Noorchashm, Hooman, Lieu, Yen K, Rostami, Susan, Greeley, Siri Atma S, Barker, Clyde F, Naji, Ali

“…Comparative study of alloimmune responses against major and minor histocompatibility Ags has been limited by the lack of suitable assays. Here, we use a…”
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In vivo MLR: a novel method for the study of alloimmune responses by Song, H.K, Noorchashm, H, Lieu, Y.K, Rostami, S, Greeley, S.A.S, Barker, C.F, Naji, A

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Murine Islet Allograft Tolerance Upon Blockade of the B-Lymphocyte Stimulator, BLyS/BAFF by PARSONS, Ronald F, MING YU, MIGONE, Thi-Sau, CANCRO, Michael P, NAJI, Ali, NOORCHASHM, Hooman, VIVEK, Kumar, ZEKAVAT, Ghazal, ROSTAMI, Susan Y, ZIAIE, Amin S, YANPING LUO, KOEBERLEIN, Brigitte, REDFIELD, Robert R, WARD, Christopher D

“…Immunologic rejection is a major barrier to successful long-term outcomes in clinical transplantation. The importance of B lymphocytes-and their secretory…”
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Characterization of the alloimmune response to minor histocompatibility antigens by in vivo MLR by Song, H.K, Noorchashm, H, Lieu, Y.K, Rostami, S, Greeley, S.A.S, Barker, C.F, Naji, A

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B lymphocytes influence the shape of the mature preimmune CD4+ TCR repertoire by Noorchashm, H, Lieu, Y.K, Song, H.K, Rostami, S.Y, Greeley, S.A.S, Noorchashm, N, Barker, C.F, Naji, A

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Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice by Naji, Ali, Greeley, Siri Atma W, Katsumata, Makoto, Yu, Liping, Eisenbarth, George S, Moore, Daniel J, Goodarzi, Heidi, Barker, Clyde F, Noorchashm, Hooman

“…The influence of maternally transmitted immunoglobulins on the development of autoimmune diabetes mellitus in genetically susceptible human progeny remains…”
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Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle by Mandik-Nayak, L, Bui, A, Noorchashm, H, Eaton, A, Erikson, J

“…Systemic lupus erythematosus (SLE) and the MRL-lpr/lpr murine model for SLE are characterized by the presence of serum anti-double-stranded (ds)DNA antibodies…”
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B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice by NOORCHASHM, H, NOORCHASHM, N, KERN, J, ROSTAMI, S. Y, BARKER, C. F, NAJI, A

“…Nonobese diabetic (NOD) mice spontaneously develop an acute onset of hyperglycemia reminiscent of human type I diabetes. The disease is the end result of a…”
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Alloreactive CD4 T Cell Activation In Vivo: An Autonomous Function of the Indirect Pathway of Alloantigen Presentation by Reed, Amy J, Noorchashm, Hooman, Rostami, Susan Y, Zarrabi, Yasaman, Perate, Alison R, Jeganathan, Arjun N, Caton, Andrew J, Naji, Ali

“…Activation of alloreactive CD4 T cells occurs via the direct and indirect pathways of alloantigen presentation. A novel TCR/alloantigen transgenic system was…”
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The role of B lymphocytes in acute allograft rejection by Noorchashm, H., Liu, C., Reed, A.J., Rostami, S., Barker, C.F., Naji, A.

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Characterization of anergic anti-DNA B cells: B cell anergy is a T cell-independent and potentially reversible process by Noorchashm, Hooman, Bui, Anh, Li, Hsiu-Ling, Eaton, Ashlyn, Mandik-Nayak, Laura, Sokol, Carrie, Potts, Kathryn M., Puré, Ellen, Erikson, Jan

“…Anti-single stranded DNA (ssDNA) and anti-double stranded DNA (dsDNA) B cells are regulated in non-autoimmune mice. In this report we show that while both…”
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The role of t/b lymphocyte collaboration in the regulation of autoimmune and alloimmune responses by Noorchashm, Hooman, Greeley, Siri A, Naji, Ali

“…The present review highlights the two areas of research pursuit in our laboratory: (1). the regulation of the autoimmune T cell response to pancreatic islet…”
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NOD B-cells Are Insufficient to Incite T-Cell-Mediated Anti-islet Autoimmunity by MOORE, Daniel J, NOORCHASHM, Hooman, LIN, Tina H, GREELEY, Siri A, NAJI, Ali

“…NOD B-cells Are Insufficient to Incite T-Cell-Mediated Anti-islet Autoimmunity Daniel J. Moore 1 , Hooman Noorchashm 2 , Tina H. Lin 2 , Siri A. Greeley 2 and…”
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Specialized CC-chemokine secretion by Th1 cells in destructive autoimmune myocarditis by Song, Howard K, Noorchashm, Hooman, Lin, Tina H, Moore, Daniel J, Greeley, Siri A, Caton, Andrew J, Naji, Ali

“…T helper (Th) 1-mediated immune responses are associated with adverse outcomes in a number of models of autoimmune disease. Previous work has focused on the…”
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A direct method for the calculation of alloreactive CD4+ T cell precursor frequency by NOORCHASHM, H, LIEU, Y. K, ROSTAMI, S. Y, SONG, H. K, GREELEY, S. A. S, BAZEL, S, BARKER, C. F, NAJI, A

“…Direct measurement of the precursor frequency of alloreactive CD4+ T cells has been impossible due to the lack of a specific means of determining the absolute…”
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