Search Results - "Noorani, Behnam"

A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity by Kadry, Hossam, Noorani, Behnam, Cucullo, Luca

“…The blood-brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain's metabolic activity…”
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Effects of Encapsulated Cells on the Physical-Mechanical Properties and Microstructure of Gelatin Methacrylate Hydrogels by Krishnamoorthy, Srikumar, Noorani, Behnam, Xu, Changxue

“…Gelatin methacrylate (GelMA) has been gaining popularity in recent years as a photo-crosslinkable biomaterial widely used in a variety of bioprinting and…”
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In vitro modeling of the neurovascular unit: advances in the field by Bhalerao, Aditya, Sivandzade, Farzane, Archie, Sabrina Rahman, Chowdhury, Ekram Ahmed, Noorani, Behnam, Cucullo, Luca

“…The blood-brain barrier (BBB) is a fundamental component of the central nervous system. Its functional and structural integrity is vital in maintaining the…”
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A Quasi-Physiological Microfluidic Blood-Brain Barrier Model for Brain Permeability Studies by Noorani, Behnam, Bhalerao, Aditya, Raut, Snehal, Nozohouri, Ehsan, Bickel, Ulrich, Cucullo, Luca

“…Microfluidics-based organ-on-a-chip technology allows for developing a new class of in-vitro blood-brain barrier (BBB) models that recapitulate many…”
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A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance and Efflux of Sucrose and Mannitol after IV Injection in Awake Mice by Noorani, Behnam, Chowdhury, Ekram Ahmed, Alqahtani, Faleh, Sajib, Md Sanaullah, Ahn, Yeseul, Nozohouri, Ehsan, Patel, Dhavalkumar, Mikelis, Constantinos, Mehvar, Reza, Bickel, Ulrich

“…Purpose To evaluate a three-compartmental semi-physiological model for analysis of uptake clearance and efflux from brain tissue of the hydrophilic markers…”
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Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using small-molecular-weight paracellular markers by Kadry, Hossam, Noorani, Behnam, Bickel, Ulrich, Abbruscato, Thomas J, Cucullo, Luca

“…Background The blood-brain barrier (BBB) plays a critical role in protecting the central nervous system (CNS) from blood-borne agents and potentially harmful…”
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LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrose by Noorani, Behnam, Chowdhury, Ekram Ahmed, Alqahtani, Faleh, Ahn, Yeseul, Patel, Dhavalkumar, Al-Ahmad, Abraham, Mehvar, Reza, Bickel, Ulrich

“…Background Understanding the pathophysiology of the blood brain-barrier (BBB) plays a critical role in diagnosis and treatment of disease conditions. Applying…”
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Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy by Bhalerao, Aditya, Raut, Snehal, Noorani, Behnam, Mancuso, Salvatore, Cucullo, Luca

“…As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully…”
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Advanced Microfluidic Vascularized Tissues as Platform for the Study of Human Diseases and Drug Development by Noorani, Behnam, Cucullo, Luca, Ahn, Yeseul, Kadry, Hossam, Bhalerao, Aditya, Raut, Snehal, Nozohouri, Ehsan, Chowdhury, Ekram Ahmed

“…The vascular system plays a critical role in human physiology and diseases. It is a complex subject to study using in vitro models due to its dynamic and…”
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Investigation of gelatin methacrylate working curves in dynamic optical projection stereolithography of vascular-like constructs by Krishnamoorthy, Srikumar, Wadnap, Soham, Noorani, Behnam, Xu, Heqi, Xu, Changxue

“…[Display omitted] •Working curves of gelatin methacrylate are characterized at various conditions.•Degree of functionalization has the most significant…”
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Understanding the brain uptake and permeability of small molecules through the BBB: A technical overview by Chowdhury, Ekram Ahmed, Noorani, Behnam, Alqahtani, Faleh, Bhalerao, Aditya, Raut, Snehal, Sivandzade, Farzane, Cucullo, Luca

“…The brain is the most important organ in our body requiring its unique microenvironment. By the virtue of its function, the blood-brain barrier poses a…”
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Isoflurane increases cell membrane fluidity significantly at clinical concentrations by Patel, Jigesh, Chowdhury, Ekram A., Noorani, Behnam, Bickel, Ulrich, Huang, Juyang

“…There is an on-going debate whether anesthetic drugs, such as isoflurane, can cause meaningful structural changes in cell membranes at clinical concentrations…”
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Venetoclax pharmacokinetics in subjects with end-stage renal disease undergoing hemodialysis by Noorani, Behnam, Menon, Rajeev, Cen, Xin, Marsh, Kennan, Huang, Weize, Gupta, Shelly, Dobkowska, Edyta, Marbury, Thomas, Salem, Ahmed H.

“…e19042 Background: Venetoclax is a first-in-class Bcl-2 inhibitor approved for the treatment of chronic lymphocytic leukemia (CLL) and acute myeloid…”
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Venetoclax pharmacokinetics in participants with end‐stage renal disease undergoing haemodialysis by Noorani, Behnam, Menon, Rajeev M., Chen, Xin, Marsh, Kennan C., Huang, Weize, Gupta, Shelly, Dobkowska, Edyta, Marbury, Thomas, Salem, Ahmed Hamed

“…Aims Renal insufficiency is a common comorbidity in patients with haematological malignancies. This study aimed to assess how end‐stage renal disease (ESRD)…”
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Estimating Brain Permeability Using In Vitro Blood-Brain Barrier Models by Nozohouri, Saeideh, Noorani, Behnam, Al-Ahmad, Abraham, Abbruscato, Thomas J

“…The blood-brain barrier (BBB) is a vital biological interface that regulates transfer of different molecules between blood and brain and, therefore, maintains…”
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Mirzotamab clezutoclax as monotherapy and in combination with taxane therapy in relapsed/refractory solid tumors: Dose expansion results by Carneiro, Benedito A., Perets, Ruth, Dowlati, Afshin, LoRusso, Patricia, Yonemori, Kan, He, Lei, Munasinghe, Wijith, Noorani, Behnam, Johnson, Eric Feral, Zugazagoitia, Jon

“…3027 Background: Mirzotamab clezutoclax (ABBV-155; Mirzo-C) is a first-in-class antibody-drug conjugate with three components: an anti–B7-H3 monoclonal…”
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Brain Uptake of [ 13 C] and [ 14 C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice by Alqahtani, Faleh, Chowdhury, Ekram Ahmed, Bhattacharya, Raktima, Noorani, Behnam, Mehvar, Reza, Bickel, Ulrich

“…Among small, hydrophilic drug-like molecules, [ C]sucrose has long been considered the gold standard for determination of blood-brain barrier permeability…”
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Effects of Volatile Anesthetics versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes by Noorani, Behnam, Chowdhury, Ekram Ahmed, Alqahtani, Faleh, Ahn, Yeseul, Nozohouri, Ehsan, Zoubi, Sumaih, Patel, Dhavalkumar, Wood, Laurence, Huang, Juyang, Siddique, Muhammad Bilal, Al-Ahmad, Abraham, Mehvar, Reza, Bickel, Ulrich

“…The purpose of this study was to investigate the effects of the volatile anesthetic agents isoflurane and sevoflurane, at clinically relevant concentrations,…”
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In-Vivo and Ex-Vivo Brain Uptake Studies of Peptidomimetic Neurolysin Activators in Healthy and Stroke Animals by Nozohouri, Saeideh, Esfahani, Shiva Hadi, Noorani, Behnam, Patel, Dhaval, Villalba, Heidi, Ghanwatkar, Yashwardhan, Rahman, Md. Shafikur, Zhang, Yong, Bickel, Ulrich, Trippier, Paul C., Karamyan, Vardan T., Abbruscato, Thomas J.

“…Purpose Neurolysin (Nln) is a peptidase that functions to preserve the brain following ischemic stroke by hydrolyzing various neuropeptides. Nln activation has…”
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Enrichment of the erythrocyte miR-451a in brain extracellular vesicles following impairment of the blood-brain barrier by Koopaei, Nasser Nassiri, Chowdhury, Ekram Ahmed, Jiang, Jinmai, Noorani, Behnam, da Silva, Lais, Bulut, Gamze, Hakimjavadi, Hesamedin, Chamala, Srikar, Bickel, Ulrich, Schmittgen, Thomas D.

“…•The blood-brain barrier of mice was disrupted by unilateral intracarotid artery infusion with hyperosmolar mannitol solution and revealed a 14-fold increase…”
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