Search Results - "Noor, Elad"
-
1
The opportunity cost of animal based diets exceeds all food losses
Published in Proceedings of the National Academy of Sciences - PNAS (10-04-2018)“…Food loss is widely recognized as undermining food security and environmental sustainability. However, consumption of resource-intensive food items instead of…”
Get full text
Journal Article -
2
Conversion of Escherichia coli to Generate All Biomass Carbon from CO2
Published in Cell (27-11-2019)“…The living world is largely divided into autotrophs that convert CO2 into biomass and heterotrophs that consume organic compounds. In spite of widespread…”
Get full text
Journal Article -
3
Glycolytic strategy as a tradeoff between energy yield and protein cost
Published in Proceedings of the National Academy of Sciences - PNAS (11-06-2013)“…Contrary to the textbook portrayal of glycolysis as a single pathway conserved across all domains of life, not all sugar-consuming organisms use the canonical…”
Get full text
Journal Article -
4
A survey of carbon fixation pathways through a quantitative lens
Published in Journal of experimental botany (01-03-2012)“…While the reductive pentose phosphate cycle is responsible for the fixation of most of the carbon in the biosphere, it has several natural substitutes. In…”
Get full text
Journal Article -
5
Visual account of protein investment in cellular functions
Published in Proceedings of the National Academy of Sciences - PNAS (10-06-2014)“…Proteomics techniques generate an avalanche of data and promise to satisfy biologists' long-held desire to measure absolute protein abundances on a genome-wide…”
Get full text
Journal Article -
6
Awakening a latent carbon fixation cycle in Escherichia coli
Published in Nature communications (16-11-2020)“…Carbon fixation is one of the most important biochemical processes. Most natural carbon fixation pathways are thought to have emerged from enzymes that…”
Get full text
Journal Article -
7
Central Carbon Metabolism as a Minimal Biochemical Walk between Precursors for Biomass and Energy
Published in Molecular cell (10-09-2010)“…Central carbon metabolism uses a complex series of enzymatic steps to convert sugars into metabolic precursors. These precursors are then used to generate the…”
Get full text
Journal Article -
8
What fraction of cellular DNA turnover becomes cfDNA?
Published in eLife (26-02-2024)“…Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the…”
Get full text
Journal Article -
9
Holistic bioengineering: rewiring central metabolism for enhanced bioproduction
Published in Biochemical journal (16-11-2017)“…What does it take to convert a living organism into a truly productive biofactory? Apart from optimizing biosynthesis pathways as standalone units, a…”
Get more information
Journal Article -
10
The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization
Published in PLoS computational biology (01-11-2016)“…Bacterial growth depends crucially on metabolic fluxes, which are limited by the cell's capacity to maintain metabolic enzymes. The necessary enzyme amount per…”
Get full text
Journal Article -
11
The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters
Published in Biochemistry (Easton) (31-05-2011)“…The kinetic parameters of enzymes are key to understanding the rate and specificity of most biological processes. Although specific trends are frequently…”
Get full text
Journal Article -
12
Pathway thermodynamics highlights kinetic obstacles in central metabolism
Published in PLoS computational biology (01-02-2014)“…In metabolism research, thermodynamics is usually used to determine the directionality of a reaction or the feasibility of a pathway. However, the relationship…”
Get full text
Journal Article -
13
Rethinking glycolysis: on the biochemical logic of metabolic pathways
Published in Nature chemical biology (17-05-2012)“…Metabolic pathways may seem arbitrary and unnecessarily complex. In many cases, a chemist might devise a simpler route for the biochemical transformation, so…”
Get full text
Journal Article -
14
eQuilibrator 3.0: a database solution for thermodynamic constant estimation
Published in Nucleic acids research (07-01-2022)“…Abstract eQuilibrator (equilibrator.weizmann.ac.il) is a database of biochemical equilibrium constants and Gibbs free energies, originally designed as a…”
Get full text
Journal Article -
15
Methanol-dependent Escherichia coli strains with a complete ribulose monophosphate cycle
Published in Nature communications (26-10-2020)“…Methanol is a biotechnologically promising substitute for food and feed substrates since it can be produced renewably from electricity, water and CO 2 …”
Get full text
Journal Article -
16
Design and analysis of synthetic carbon fixation pathways
Published in Proceedings of the National Academy of Sciences - PNAS (11-05-2010)“…Carbon fixation is the process by which CO₂ is incorporated into organic compounds. In modern agriculture in which water, light, and nutrients can be abundant,…”
Get full text
Journal Article -
17
Cross-species analysis traces adaptation of Rubisco toward optimality in a low-dimensional landscape
Published in Proceedings of the National Academy of Sciences - PNAS (23-02-2010)“…Rubisco (D-ribulose 1,5-bisphosphate carboxylase/oxygenase), probably the most abundant protein in the biosphere, performs an essential part in the process of…”
Get full text
Journal Article -
18
Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro kcat measurements
Published in Proceedings of the National Academy of Sciences - PNAS (22-03-2016)“…Turnover numbers, also known as kcat values, are fundamental properties of enzymes. However, kcat data are scarce and measured in vitro, thus may not…”
Get full text
Journal Article -
19
The global biomass of wild mammals
Published in Proceedings of the National Academy of Sciences - PNAS (07-03-2023)“…Wild mammals are icons of conservation efforts, yet there is no rigorous estimate available for their overall global biomass. Biomass as a metric allows us to…”
Get full text
Journal Article -
20
Varying environments can speed up evolution
Published in Proceedings of the National Academy of Sciences - PNAS (21-08-2007)“…Simulations of biological evolution, in which computers are used to evolve systems toward a goal, often require many generations to achieve even simple goals…”
Get full text
Journal Article