Search Results - "Noonan, Douglas M."

Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy by Albini, Adriana, Bruno, Antonino, Noonan, Douglas M, Mortara, Lorenzo

“…The critical role of angiogenesis in promoting tumor growth and metastasis is strongly established. However, tumors show considerable variation in angiogenic…”
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Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression by Bruno, Antonino, Mortara, Lorenzo, Baci, Denisa, Noonan, Douglas M, Albini, Adriana

“…Myeloid-derived suppressor cells (MDSCs) contribute to the induction of an immune suppressive/anergic, tumor permissive environment. MDSCs act as…”
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Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes by Focaccetti, Chiara, Bruno, Antonino, Magnani, Elena, Bartolini, Desirée, Principi, Elisa, Dallaglio, Katiuscia, Bucci, Eraldo O, Finzi, Giovanna, Sessa, Fausto, Noonan, Douglas M, Albini, Adriana

“…Antimetabolites are a class of effective anticancer drugs interfering in essential biochemical processes. 5-Fluorouracil (5-FU) and its prodrug Capecitabine…”
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Microalgal Derivatives as Potential Nutraceutical and Food Supplements for Human Health: A Focus on Cancer Prevention and Interception by Galasso, Christian, Gentile, Antonio, Orefice, Ida, Ianora, Adrianna, Bruno, Antonino, Noonan, Douglas M, Sansone, Clementina, Albini, Adriana, Brunet, Christophe

“…Epidemiological studies are providing strong evidence on beneficial health effects from dietary measures, leading scientists to actively investigate which…”
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The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions by Carlini, Valentina, Noonan, Douglas M, Abdalalem, Eslam, Goletti, Delia, Sansone, Clementina, Calabrone, Luana, Albini, Adriana

“…Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating inflammation and in maintaining cell homeostasis. It primarily acts…”
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The Ovarian Cancer Tumor Immune Microenvironment (TIME) as Target for Therapy: A Focus on Innate Immunity Cells as Therapeutic Effectors by Baci, Denisa, Bosi, Annalisa, Gallazzi, Matteo, Rizzi, Manuela, Noonan, Douglas M, Poggi, Alessandro, Bruno, Antonino, Mortara, Lorenzo

“…Ovarian cancer (OvCA) accounts for one of the leading causes of death from gynecologic malignancy. Despite progress in therapy improvements in OvCA, most…”
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Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention by Albini, Adriana, Pennesi, Giuseppina, Donatelli, Francesco, Cammarota, Rosaria, De Flora, Silvio, Noonan, Douglas M.

“…Due to the aging of the populations of developed countries and a common occurrence of risk factors, it is increasingly probable that a patient may have both…”
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The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells by Orecchioni, Stefania, Reggiani, Francesca, Talarico, Giovanna, Mancuso, Patrizia, Calleri, Angelica, Gregato, Giuliana, Labanca, Valentina, Noonan, Douglas M., Dallaglio, Katiuscia, Albini, Adriana, Bertolini, Francesco

“…The human white adipose tissue (WAT) contains progenitors with cooperative roles in breast cancer (BC) angiogenesis, local and metastatic progression. The…”
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MMP-9 and IL-1β as Targets for Diatoxanthin and Related Microalgal Pigments: Potential Chemopreventive and Photoprotective Agents by Pistelli, Luigi, Sansone, Clementina, Smerilli, Arianna, Festa, Marco, Noonan, Douglas M, Albini, Adriana, Brunet, Christophe

“…Photochemoprevention can be a valuable approach to counteract the damaging effects of environmental stressors (e.g., UV radiations) on the skin. Pigments are…”
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Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies by Baci, Denisa, Bruno, Antonino, Cascini, Caterina, Gallazzi, Matteo, Mortara, Lorenzo, Sessa, Fausto, Pelosi, Giuseppe, Albini, Adriana, Noonan, Douglas M

“…Prostate cancer (PCa) is a leading cause of cancer-related death in males worldwide. Exacerbated inflammation and angiogenesis have been largely demonstrated…”
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Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity by Albini, Adriana, Bruno, Antonino, Gallo, Cristina, Pajardi, Giorgio, Noonan, Douglas M, Dallaglio, Katiuscia

“…Tumor cells able to recapitulate tumor heterogeneity have been tracked, isolated and characterized in different tumor types, and are commonly named Cancer Stem…”
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The Proangiogenic Phenotype of Natural Killer Cells in Patients with Non-Small Cell Lung Cancer by Bruno, Antonino, Focaccetti, Chiara, Pagani, Arianna, Imperatori, Andrea S, Spagnoletti, Marco, Rotolo, Nicola, Cantelmo, Anna Rita, Franzi, Francesca, Capella, Carlo, Ferlazzo, Guido, Mortara, Lorenzo, Albini, Adriana, Noonan, Douglas M

“…Abstract The tumor microenvironment can polarize innate immune cells to a proangiogenic phenotype. Decidual natural killer (dNK) cells show an angiogenic…”
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Prostate Cancer Peripheral Blood NK Cells Show Enhanced CD9, CD49a, CXCR4, CXCL8, MMP-9 Production and Secrete Monocyte-Recruiting and Polarizing Factors by Gallazzi, Matteo, Baci, Denisa, Mortara, Lorenzo, Bosi, Annalisa, Buono, Giuseppe, Naselli, Angelo, Guarneri, Andrea, Dehò, Federico, Capogrosso, Paolo, Albini, Adriana, Noonan, Douglas M, Bruno, Antonino

“…Natural killer (NK) cells, effector lymphocytes of the innate immunity, have been shown to be altered in several cancers, both at tissue and peripheral levels…”
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Paradoxic effects of metformin on endothelial cells and angiogenesis by Dallaglio, Katiuscia, Bruno, Antonino, Cantelmo, Anna R., Esposito, Alessia I., Ruggiero, Luca, Orecchioni, Stefania, Calleri, Angelica, Bertolini, Francesco, Pfeffer, Ulrich, Noonan, Douglas M., Albini, Adriana

“…Summary We have investigated the effect of metformin on the mechanisms of angiogenesis. We show that metformin, particularly in the context of obesity,…”
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Downregulation of Pro-Inflammatory and Pro-Angiogenic Pathways in Prostate Cancer Cells by a Polyphenol-Rich Extract from Olive Mill Wastewater by Baci, Denisa, Gallazzi, Matteo, Cascini, Caterina, Tramacere, Matilde, De Stefano, Daniela, Bruno, Antonino, Noonan, Douglas M, Albini, Adriana

“…Dietary phytochemicals are particularly attractive for chemoprevention and are able to modulate several signal transduction pathways linked with cancer. Olive…”
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Orchestration of angiogenesis by immune cells by Bruno, Antonino, Pagani, Arianna, Pulze, Laura, Albini, Adriana, Dallaglio, Katiuscia, Noonan, Douglas M, Mortara, Lorenzo

“…It is widely accepted that the tumor microenvironment (TUMIC) plays a major role in cancer and is indispensable for tumor progression. The TUMIC involves many…”
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Acetyl-l-carnitine is an anti-angiogenic agent targeting the VEGFR2 and CXCR4 pathways by Baci, Denisa, Bruno, Antonino, Bassani, Barbara, Tramacere, Matilde, Mortara, Lorenzo, Albini, Adriana, Noonan, Douglas M.

“…Carnitines play an important role in the energy exchange in cells, and are involved in the transport of fatty acids across the inner mitochondrial membrane…”
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Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis by Bruno, Antonino, Noonan, Douglas M., Valli, Roberto, Porta, Giovanni, Taramelli, Roberto, Mortara, Lorenzo, Acquati, Francesco

“…Ovarian cancer represents one of the most malignant gynecological cancers worldwide, with an overall 5-year survival rate, being locked in the 25–30% range in…”
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The ‘chemoinvasion’ assay, 25 years and still going strong: the use of reconstituted basement membranes to study cell invasion and angiogenesis by Albini, Adriana, Noonan, Douglas M

“…Invasive and metastatic cells must cross basement membranes (BMs) in order to disseminate to distant sites. The ‘chemoinvasion assay’ using a reconstituted…”
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Preliminary Evidence for IL-10-Induced ACE2 mRNA Expression in Lung-Derived and Endothelial Cells: Implications for SARS-Cov-2 ARDS Pathogenesis by Albini, Adriana, Calabrone, Luana, Carlini, Valentina, Benedetto, Nadia, Lombardo, Michele, Bruno, Antonino, Noonan, Douglas M.

“…Angiotensin-converting enzyme 2 (ACE2) is a receptor for the spike protein of SARS-COV-2 that allows viral binding and entry and is expressed on the surface of…”
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