Search Results - "Nonne, Christelle"

Transdermal Administration of Nanobody Molecules using Hydrogel‐Forming Microarray Patch Technology: A Unique Delivery Approach by Hutton, Aaron R. J., Kirkby, Melissa, Van Bogaert, Tom, Casteels, Peter, Nonne, Christelle, De Brabandere, Veronique, Vyver, Ortwin Van, Vora, Lalit K., Tekko, Ismaiel A., McCarthy, Helen O., Donnelly, Ryan F.

“…Nanobody molecules, derived from heavy‐chain only antibodies in camelids, represent the next generation of biotherapeutics. In addition to low immunogenicity,…”
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Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion by Léon, Catherine, Eckly, Anita, Hechler, Béatrice, Aleil, Boris, Freund, Monique, Ravanat, Catherine, Jourdain, Marie, Nonne, Christelle, Weber, Josiane, Tiedt, Ralph, Gratacap, Marie-Pierre, Severin, Sonia, Cazenave, Jean-Pierre, Lanza, François, Skoda, Radek, Gachet, Christian

“…Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in bleeding disorders characterized by a macrothrombocytopenia. To understand…”
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MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice by Hechler, Béatrice, Nonne, Christelle, Roh, Eun Joo, Cattaneo, Marco, Cazenave, Jean-Pierre, Lanza, François, Jacobson, Kenneth A, Gachet, Christian

“…The platelet P2Y(1) ADP receptor is an attractive target for new antiplatelet drugs. However, because of the lack of strong and stable antagonists, only a few…”
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Targeted Identification of Sialoglycoproteins in Hypoxic Endothelial Cells and Validation in Zebrafish Reveal Roles for Proteins in Angiogenesis by Delcourt, Nicolas, Quevedo, Celia, Nonne, Christelle, Fons, Pierre, O'Brien, Donogh, Loyaux, Denis, Diez, Maria, Autelitano, François, Guillemot, Jean-Claude, Ferrara, Pascual, Muriana, Arantza, Callol, Carlos, Hérault, Jean-Pascal, Herbert, Jean-Marc, Favre, Gilles, Bono, Françoise

“…The formation of new vessels in the tumor, termed angiogenesis, is essential for primary tumor growth and facilitates tumor invasion and metastasis. Hypoxia…”
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Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRγ deficiency by Mangin, Pierre, Yap, Cindy L., Nonne, Christelle, Sturgeon, Sharelle A., Goncalves, Isaac, Yuan, Yuping, Schoenwaelder, Simone M., Wright, Christine E., Lanza, Francois, Jackson, Shaun P.

“…Fibrillar collagens are among the most potent activators of platelets and play an important role in the initiation of thrombosis. The glycoprotein VI…”
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Brimonidine displays anti‐inflammatory properties in the skin through the modulation of the vascular barrier function by Bertino, Béatrice, Blanchet‐Réthoré, Sandrine, Thibaut de Ménonville, Séverine, Reynier, Philippe, Méhul, Bruno, Bogouch, Audrey, Gamboa, Bastien, Dugaret, Anne Sophie, Zugaj, Didier, Petit, Laurent, Roquet, Manon, Piwnica, David, Vial, Emmanuel, Bourdès, Valerie, Voegel, Johannes J., Nonne, Christelle

“…Background Rosacea is a chronic inflammatory skin disease. Characteristic vascular changes in rosacea skin include enlarged, dilated vessels of the upper…”
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Protective Effect of Dermal Brimonidine Applications Against UV Radiation-induced Skin Tumors, Epidermal Hyperplasia and Cell Proliferation in the Skin of Hairless Mice by Bouvier, Guy, Learn, Douglas B., Nonne, Christelle, Feraille, Gérard, Vial, Emmanuel, Ruty, Bernard

“…Brimonidine at 0.18%, 1% and 2% concentrations applied topically in hairless mice significantly decreased tumor burden and incidences of erythema, flaking,…”
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Importance of Platelet Phospholipase Cγ2 Signaling in Arterial Thrombosis as a Function of Lesion Severity by Nonne, Christelle, Lenain, Nadège, Hechler, Béatrice, Mangin, Pierre, Cazenave, Jean-Pierre, Gachet, Christian, Lanza, François

“…OBJECTIVE—Platelet activation occurs in response to adhesion receptors for von Willebrand factor (GPIb-V-IX) and collagen (GPVI and α2β1 integrin) acting…”
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Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion: Role of myosin IIA in hemostasis and thrombosis by Léon, Catherine, Eckly, Anita, Hechler, Béatrice, Aleil, Boris, Freund, Monique, Ravanat, Catherine, Jourdain, Marie, Nonne, Christelle, Weber, Josiane, Tiedt, Ralph, Gratacap, Marie-Pierre, Severin, Sonia, Cazenave, Jean-Pierre, Lanza, François, Skoda, Radek, Gachet, Christian

“…Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in bleeding disorders characterized by a macrothrombocytopenia. To understand…”
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Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency by Mangin, Pierre, Yap, Cindy L, Nonne, Christelle, Sturgeon, Sharelle A, Goncalves, Isaac, Yuan, Yuping, Schoenwaelder, Simone M, Wright, Christine E, Lanza, Francois, Jackson, Shaun P

“…Fibrillar collagens are among the most potent activators of platelets and play an important role in the initiation of thrombosis. The glycoprotein VI…”
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Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. Commentary by SHIVDASANI, Ramesh A, LEON, Catherine, TEDT, Ralph, GRATACAP, Marie-Pierre, SEVERIN, Sonia, CAZENAVE, Jean-Pierre, LANZA, Francois, SKODA, Radek, GACHET, Christian, ECKLY, Anita, HECHLER, Béatrice, ALEIL, Boris, FREUND, Monique, RAVANAT, Catherine, JOURDAIN, Marie, NONNE, Christelle, WEBER, Josiane

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Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRγ deficiency. Commentary by KAHN, Mark L, MANGIN, Pierre, JACKSON, Shaun P, YAP, Cindy L, NONNE, Christelle, STURGEON, Sharelle A, GONCALVES, Isaac, YUPING YUAN, SCHOENWAELDER, Simone M, WRIGHT, Christine E, LANZA, Francois

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Importance of platelet phospholipase Cgamma2 signaling in arterial thrombosis as a function of lesion severity by Nonne, Christelle, Lenain, Nadège, Hechler, Béatrice, Mangin, Pierre, Cazenave, Jean-Pierre, Gachet, Christian, Lanza, François

“…Platelet activation occurs in response to adhesion receptors for von Willebrand factor (GPIb-V-IX) and collagen (GPVI and alpha2beta1 integrin) acting upstream…”
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Atherothrombosis: transposition of the models to the clinic and reciprocally by Gachet, Christian, Hechler, Béatrice, Nonne, Christelle, Cazenave, Jean-Pierre, Lanza, François, Aleil, Boris

“…The transposition of experimental models to clinical situations in the atherothrombosis field will be illustrated by two examples: in one hand, the steps of…”
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