Search Results - "Nonen, Shinpei"

Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways by Kato, Masaki, Ogata, Haruhiko, Tahara, Hidetoshi, Shimamoto, Akira, Takekita, Yoshiteru, Koshikawa, Yosuke, Nishida, Keiichiro, Nonen, Shinpei, Higasa, Koichiro, Kinoshita, Toshihiko

“…Major depressive disorder (MDD) is a life-impairing disorder, and early successful treatment is important for a favorable prognosis. However, early response to…”
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Changes in Multiple microRNA Levels with Antidepressant Treatment Are Associated with Remission and Interact with Key Pathways: A Comprehensive microRNA Analysis by Funatsuki, Toshiya, Ogata, Haruhiko, Tahara, Hidetoshi, Shimamoto, Akira, Takekita, Yoshiteru, Koshikawa, Yosuke, Nonen, Shinpei, Higasa, Koichiro, Kinoshita, Toshihiko, Kato, Masaki

“…Individual treatment outcomes to antidepressants varies widely, yet the determinants to this difference remain elusive. MicroRNA (miRNA) gene expression…”
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Lower doses of carvedilol in Japanese heart failure patients with reduced ejection fraction could show the potential to be non-inferior to higher doses in US patients: An international collaborative observational study by Maeda, Makiko, Humber, Douglas, Hida, Eisuke, Ohtani, Tomohito, Wang, Guannan, Wu, Tong, Takeda, Shiori, Situ, Jacinta N, Hayashi, Jun, Nonen, Shinpei, Takeda, Toshihiro, Okamoto, Hiroshi, Hori, Masatsugu, Sakata, Yasushi, Fujio, Yasushi, Tsunoda, Shirley M

“…The Japanese national guidelines recommend significantly lower doses of carvedilol for heart failure with reduced ejection fraction (HFrEF) management than the…”
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Connective tissue growth factor induces cardiac hypertrophy through Akt signaling by Hayata, Nozomi, Fujio, Yasushi, Yamamoto, Yasuhiro, Iwakura, Tomohiko, Obana, Masanori, Takai, Mika, Mohri, Tomomi, Nonen, Shinpei, Maeda, Makiko, Azuma, Junichi

“…In the process of cardiac remodeling, connective tissue growth factor (CTGF/CCN2) is secreted from cardiac myocytes. Though CTGF is well known to promote…”
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HTR1A Gene Polymorphisms and 5-HT1A Receptor Partial Agonist Antipsychotics Efficacy in Schizophrenia by Takekita, Yoshiteru, Fabbri, Chiara, Kato, Masaki, Nonen, Shinpei, Sakai, Shiho, Sunada, Naotaka, Koshikawa, Yosuke, Wakeno, Masataka, Okugawa, Gaku, Kinoshita, Toshihiko, Serretti, Alessandro

“…Individual differences in serotonin 1A (5-HT1A) receptor may result in variable response to antipsychotics with 5-HT1A receptor partial agonism. We…”
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Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder by Amare, Azmeraw T, Schubert, Klaus Oliver, Tekola-Ayele, Fasil, Hsu, Yi-Hsiang, Sangkuhl, Katrin, Jenkins, Gregory, Whaley, Ryan M, Barman, Poulami, Batzler, Anthony, Altman, Russ B, Arolt, Volker, Brockmöller, Jürgen, Chen, Chia-Hui, Domschke, Katharina, Hall-Flavin, Daniel K, Hong, Chen-Jee, Illi, Ari, Ji, Yuan, Kampman, Olli, Kinoshita, Toshihiko, Leinonen, Esa, Liou, Ying-Jay, Mushiroda, Taisei, Nonen, Shinpei, Skime, Michelle K, Wang, Liewei, Kato, Masaki, Liu, Yu-Li, Praphanphoj, Verayuth, Stingl, Julia C, Bobo, William V, Tsai, Shih-Jen, Kubo, Michiaki, Klein, Teri E, Weinshilboum, Richard M, Biernacka, Joanna M, Baune, Bernhard T

“…Studies reported a strong genetic correlation between the Big Five personality traits and major depressive disorder (MDD). Moreover, personality traits are…”
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Polymorphisms of CYP2D6 Gene and Gefitinib-Induced Hepatotoxicity by Takimoto, Takayuki, Kijima, Takashi, Otani, Yasushi, Nonen, Shinpei, Namba, Yoshinobu, Mori, Masahide, Yokota, Soichiro, Minami, Seigo, Komuta, Kiyoshi, Uchida, Junji, Imamura, Fumio, Furukawa, Mitsugi, Tsuruta, Naotoshi, Fujio, Yasushi, Azuma, Junichi, Tachibana, Isao, Kumanogoh, Atsushi

“…Micro-Abstract Polymorphisms of CYP2D6 were analyzed in 55 patients with non–small-cell lung cancer (NSCLC) who experienced gefitinib-induced hepatotoxicity…”
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Minimal dose for effective clinical outcome and predictive factors for responsiveness to carvedilol: Japanese chronic heart failure (J-CHF) study by Okamoto, Hiroshi, Hori, Masatsugu, Matsuzaki, Masunori, Tsutsui, Hiroyuki, Yamazaki, Tsutomu, Nagai, Ryozo, Yoshikawa, Tsutomu, Fujio, Yasushi, Nonen, Shinpei, Azuma, Junichi, Izumi, Tohru, Ohashi, Yasuo, Kitabatake, Akira

“…Abstract Background In chronic heart failure (CHF), it remains unclear whether the minimal dose of beta-blockade is related to survival benefits and which…”
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Cigarette Smoke Extract Induces CYP2B6 through Constitutive Androstane Receptor in Hepatocytes by WASHIO, Ikumi, MAEDA, Makiko, SUGIURA, Chika, SHIGA, Ryota, YOSHIDA, Mitsuhiro, NONEN, Shinpei, FUJIO, Yasushi, AZUMA, Tunichi

“…Smoking induces a wide range of drug-metabolizing enzymes. Among them, CYP2B6 as well as CYP1A2 is well known to be up-regulated in smokers. Although the…”
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Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients by Ohno, Masako, Yamamoto, Akiko, Ono, Ayumu, Miura, Genta, Funamoto, Masanobu, Takemoto, Yasuhiko, Otsu, Kinya, Kouno, Yasushi, Tanabe, Tomoko, Masunaga, Yuiko, Nonen, Shinpei, Fujio, Yasushi, Azuma, Junichi

“…Objective The aim of this study was to investigate the influence of clinical and genetic factors on warfarin dose requirements in the Japanese population…”
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Simple and accurate determination of CYP2D6 gene copy number by a loop-mediated isothermal amplification method and an electrochemical DNA chip by Nakamura, Naoko, Fukuda, Tsuyoshi, Nonen, Shinpei, Hashimoto, Koji, Azuma, Junichi, Gemma, Nobuhiro

“…A combination technology of a loop-mediated isothermal amplification (LAMP) method and an electrochemical DNA chip has been developed. In this study, the…”
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Genetic polymorphisms of CYP17A1 in steroidogenesis pathway are associated with risk of progression to castration-resistant prostate cancer in Japanese men receiving androgen deprivation therapy by Yamada, Takeshi, Nakayama, Masashi, Shimizu, Tomohito, Nonen, Shinpei, Nakai, Yasutomo, Nishimura, Kazuo, Fujio, Yasushi, Okuyama, Akihiko, Azuma, Junichi, Nonomura, Norio

“…Background Hormone ablation therapy is the standard therapy for prostate cancer; however, there are large individual differences in the duration of response to…”
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The Alpha 2A-Adrenergic Receptor Gene Polymorphism Modifies Antidepressant Responses to Milnacipran by WAKENO, Masataka, KATO, Masaki, OKUGAWA, Gaku, FUKUDA, Tsuyoshi, HOSOI, Yuka, TAKEKITA, Yoshiteru, YAMASHITA, Megumi, NONEN, Shinpei, AZUMA, Junichi, KINOSHITA, Toshihiko

“…The alpha 2A-adrenergic receptor (ADRA2A) plays a central role in the regulation of systemic sympathetic activity. Recently, the functional defect of ADRA2A…”
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Genetic Polymorphisms of Glycine N-acyltransferase in Japanese Individuals by Yamamoto, Akiko, Nonen, Shinpei, Fukuda, Tsuyoshi, Yamazaki, Hiroshi, Azuma, Junichi

“…In the present study, we identified 5 novel single nucleotide polymorphisme (SNPs) in the gene of glycine N-acyltransferase (GlyAT) by resequencing the entire…”
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Effect of basic fibroblast growth factor (FGF2) gene polymorphisms on SSRIs treatment response and side effects by Kato, Masaki, Okugawa, Gaku, Wakeno, Masataka, Takekita, Yoshiteru, Nonen, Shinpei, Tetsuo, Shinji, Nishida, Keiichiro, Azuma, Junichi, Kinoshita, Toshihiko, Serretti, Alessandro

“…Abstract Antidepressant response usually appears in 2 to 4 weeks and 30–40% of patients do not show a significant response although biochemical changes of…”
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Regulation of cytochrome P450 2E1 under hypertonic environment through TonEBP in human hepatocytes by Ito, Takashi, Asakura, Koko, Tougou, Katsuhiko, Fukuda, Tsuyoshi, Kubota, Ryuji, Nonen, Shinpei, Fujio, Yasushi, Azuma, Junichi

“…Whereas the liver as well as the other organs are continually exposed to the change of osmotic status, it has never been investigated whether activities and…”
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Neuropsychological Evaluation and Cerebral Blood Flow Effects of Apolipoprotein E4 in Alzheimer's Disease Patients after One Year of Treatment: An Exploratory Study by Suwa, Azusa, Nishida, Keiichiro, Utsunomiya, Keita, Nonen, Shinpei, Yoshimura, Masafumi, Takekita, Yoshiteru, Wakeno, Masataka, Tajika, Aran, Yoshino, Maki, Koshikawa, Yosuke, Kato, Masaki, Kinoshita, Toshihiko

“…Background: Alzheimer's disease (AD) is affected by apolipoprotein E (ApoE); however, its effects assessed by means of cognitive tests and by neuroimaging have…”
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Adrenergic β1 Receptor Polymorphism (Ser49Gly) Is Associated with Obesity in Type II Diabetic Patients by Nonen, Shinpei, Yamamoto, Isamu, Liu, Jianmin, Maeda, Makiko, Motomura, Takashi, Igarashi, Tsuyoshi, Fujio, Yasushi, Azuma, Junichi

“…In the process of lipolysis, adipocytes are stimulated by catecholamines through β1, β2, and β3 adrenergic receptors (ARs). So far, β2 and β3 AR polymorphisms…”
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MTHFR gene polymorphism as a risk factor for diabetic retinopathy in type 2 diabetic patients without serum creatinine elevation by Maeda, Makiko, Yamamoto, Isamu, Fukuda, Masakatsu, Nishida, Mari, Fujitsu, Junko, Nonen, Shinpei, Igarashi, Tsuyoshi, Motomura, Takashi, Inaba, Makiko, Fujio, Yasushi, Azuma, Junichi

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Genetic testing by Azuma, Junichi, Nonen, Shinpei

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