Obesity and clinical severity in patients with COVID-19: a scoping review protocol

Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 strain, was first identified in late 2019 in China. The outcomes of patients affected by the virus can worsen, developing acute respiratory failure and other serious complications, especially in older indiv...

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Bibliographic Details
Published in:	Systematic reviews Vol. 10; no. 1; pp. 51 - 6
Main Authors:	Costa, Marcela Larissa, Souza, Carlos Adriano Santos, Silva, Ana Caroline Cardoso, Santos, Dayane Franciely Conceição, Nonato, Edilene Fernandes, Santana, Francismayne Batista, Dos Santos Dias, Giselle, Barreto, Jessyca Teles, Costa, Laís Santos, Costa, Maria Carolina Barros, das Neves Ferreira, Tamila, Santana, Jeniffer Santos, Mendes-Netto, Raquel Simões, do Nascimento, Tereza Virgínia Silva Bezerra, Nunes, Marco Antônio Prado, de Souza, Márcia Ferreira Cândido
Format:	Journal Article
Language:	English
Published:	England BioMed Central 07-02-2021 BMC
Subjects:	Comorbidity Coronaviruses COVID-19 COVID-19 - complications COVID-19 - physiopathology Humans Internationality Mortality Obesity Obesity - complications Pathophysiology Protocol Research Design Respiratory failure Risk factor Risk factors SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severity Severity of Illness Index COVID-19 Obesity Severity Risk factor
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Summary:	Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 strain, was first identified in late 2019 in China. The outcomes of patients affected by the virus can worsen, developing acute respiratory failure and other serious complications, especially in older individuals and people with obesity and comorbidities. Thus, obese patients tend to have a more severe course of COVID-19. Thus, this review aims to synthesize the evidence in the literature that associates COVID-19 and the severity of clinical outcomes in infected obese patients. This protocol was designed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols Statement. Scientific and gray literature will be systematically selected from PubMed/MEDLINE, Latin American Literature in Health Sciences, Online Scientific Electronic Library, Scopus, ScienceDirect, Web of Science, Embase, and Cochrane. The selection of articles will be limited to studies published in English, Portuguese, and Spanish from December 2019 onwards. The main clinical outcomes will be clinical severity in obese patients with COVID-19 as tachypnea (respiratory rate, ≥ 30 breaths per minute), hypoxemia (oxygen saturation, ≤ 93%), the ratio of the partial pressure of arterial oxygen to fraction of inspired oxygen (< 300), lung infiltrate (> 50% of the lung field involved within 24-48 h), diagnosis of the severe acute respiratory syndrome, need of invasive mechanical ventilation, and mortality. Two reviewers will independently screen all citations, full-text articles, and abstract data. Selection bias will be minimized by excluding studies published before December 2019. Conflicts will be resolved through a third reviewer and consensus-building. Moreover, findings will be reported using narrative synthesis and tabulation of the summaries. Given the need for early detection of the possible implications and treatment for patients with obesity diagnosed with COVID-19, the scoping review will be useful to capture the state of the current literature, identify the gaps, and make recommendations for future research for directing the conduct and optimization of therapies in these patients by the multiprofessional teams. Open Science Framework: https://osf.io/xrkec.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2046-4053 2046-4053
DOI:	10.1186/s13643-021-01603-x