Search Results - "Nonami, Atsushi"

Inhibition of USP10 induces degradation of oncogenic FLT3 by Weisberg, Ellen L, Schauer, Nathan J, Yang, Jing, Lamberto, Ilaria, Doherty, Laura, Bhatt, Shruti, Nonami, Atsushi, Meng, Chengcheng, Letai, Anthony, Wright, Renee, Tiv, Hong, Gokhale, Prafulla C, Ritorto, Maria Stella, De Cesare, Virginia, Trost, Matthias, Christodoulou, Alexandra, Christie, Amanda, Weinstock, David M, Adamia, Sophia, Stone, Richard, Chauhan, Dharminder, Anderson, Kenneth C, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Sattler, Martin, Gray, Nathanael S, Griffin, James D, Buhrlage, Sara J

“…An inhibitor of the deubiquitinase (DUB) USP10 regulates the degradation of oncogenic FLT3, thus defining USP10 as a DUB for FLT3 and providing a therapeutic…”
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Requirement for CDK6 in MLL-rearranged acute myeloid leukemia by Placke, Theresa, Faber, Katrin, Nonami, Atsushi, Putwain, Sarah L., Salih, Helmut R., Heidel, Florian H., Krämer, Alwin, Root, David E., Barbie, David A., Krivtsov, Andrei V., Armstrong, Scott A., Hahn, William C., Huntly, Brian J., Sykes, Stephen M., Milsom, Michael D., Scholl, Claudia, Fröhling, Stefan

“…Chromosomal rearrangements involving the H3K4 methyltransferase mixed-lineage leukemia (MLL) trigger aberrant gene expression in hematopoietic progenitors and…”
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Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth by Oshima, Tsuyoshi, Niwa, Yoshimi, Kuwata, Keiko, Srivastava, Ashutosh, Hyoda, Tomoko, Tsuchiya, Yoshiki, Kumagai, Megumi, Tsuyuguchi, Masato, Tamaru, Teruya, Sugiyama, Akiko, Ono, Natsuko, Zolboot, Norjin, Aikawa, Yoshiki, Oishi, Shunsuke, Nonami, Atsushi, Arai, Fumio, Hagihara, Shinya, Yamaguchi, Junichiro, Tama, Florence, Kunisaki, Yuya, Yagita, Kazuhiro, Ikeda, Masaaki, Kinoshita, Takayoshi, Kay, Steve A, Itami, Kenichiro, Hirota, Tsuyoshi

“…Compounds targeting the circadian clock have been identified as potential treatments for clock-related diseases, including cancer. Our cell-based phenotypic…”
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Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097 by Weisberg, Ellen, Halilovic, Ensar, Cooke, Vesselina G, Nonami, Atsushi, Ren, Tao, Sanda, Takaomi, Simkin, Irene, Yuan, Jing, Antonakos, Brandon, Barys, Louise, Ito, Moriko, Stone, Richard, Galinsky, Ilene, Cowens, Kristen, Nelson, Erik, Sattler, Martin, Jeay, Sebastien, Wuerthner, Jens U, McDonough, Sean M, Wiesmann, Marion, Griffin, James D

“…The tumor suppressor p53 is a key regulator of apoptosis and functions upstream in the apoptotic cascade by both indirectly and directly regulating Bcl-2…”
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Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q− syndrome by Kumar, Madhu S., Narla, Anupama, Nonami, Atsushi, Mullally, Ann, Dimitrova, Nadya, Ball, Brian, McAuley, J. Randall, Poveromo, Luke, Kutok, Jeffrey L., Galili, Naomi, Raza, Azra, Attar, Eyal, Gilliland, D. Gary, Jacks, Tyler, Ebert, Benjamin L.

“…Large chromosomal deletions are among the most common molecular abnormalities in cancer, yet the identification of relevant genes has proven difficult. The 5q−…”
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Selective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells by Weisberg, Ellen, Liu, Qingsong, Zhang, Xin, Nelson, Erik, Sattler, Martin, Liu, Feiyang, Nicolais, Maria, Zhang, Jianming, Mitsiades, Constantine, Smith, Robert W, Stone, Richard, Galinsky, Ilene, Nonami, Atsushi, Griffin, James D, Gray, Nathanael

“…Tyrosine kinase inhibitor (TKI)-treated acute myeloid leukemia (AML) patients commonly show rapid and significant peripheral blood blast cell reduction,…”
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Identification of ILK as a novel therapeutic target for acute and chronic myeloid leukemia by de la Puente, Pilar, Weisberg, Ellen, Muz, Barbara, Nonami, Atsushi, Luderer, Micah, Stone, Richard M, Melo, Junia V, Griffin, James D, Azab, Abdel Kareem

“…Highlights • Compound 22 is a potent and targeted ILK inhibitor. • ILK inhibition is an effective treatment for acute and chronic myeloid leukemias. • ILK is a…”
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Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia by Yoshimura, Akihiko, Taketomi, Takaharu, Yoshiga, Daigo, Taniguchi, Koji, Kobayashi, Takashi, Nonami, Atsushi, Kato, Reiko, Sasaki, Mika, Sasaki, Atsuo, Ishibashi, Hitoshi, Moriyama, Maiko, Nakamura, Kei-ichiro, Nishimura, Junji

“…We report here that loss of the Sprouty2 gene (also known as Spry2) in mice resulted in enteric nerve hyperplasia, which led to esophageal achalasia and…”
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Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis by Nagafuji, Koji, Nonami, Atsushi, Kumano, Takashi, Kikushige, Yoshikane, Yoshimoto, Goichi, Takenaka, Katsuto, Shimoda, Kazuya, Ohga, Shouichi, Yasukawa, Masaki, Horiuchi, Hisanori, Ishii, Eiichi, Harada, Mine

“…From the Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (KN, AN, TK, YK, GY, KT, KS, MH); Department…”
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Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness by Inoue, Hiromasa, Kato, Reiko, Fukuyama, Satoru, Nonami, Atsushi, Taniguchi, Kouji, Matsumoto, Koichiro, Nakano, Takako, Tsuda, Miyuki, Matsumura, Mikiko, Kubo, Masato, Ishikawa, Fumihiko, Moon, Byoung-gon, Takatsu, Kiyoshi, Nakanishi, Yoichi, Yoshimura, Akihiko

“…T helper 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, play a critical role in allergic asthma. These cytokines transmit signals through the…”
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Encephalomyelitis Mimicking Multiple Sclerosis Associated with Chronic Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation by Matsuo, Yayoi, Kamezaki, Kenjiro, Takeishi, Shoichiro, Takenaka, Katsuto, Eto, Tetsuya, Nonami, Atsushi, Miyamoto, Toshihiro, Iwasaki, Hiromi, Harada, Naoki, Nagafuji, Koji, Teshima, Takanori, Akashi, Koichi

“…We describe a case of encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease (GVHD) occurring after allogeneic bone…”
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Spred-1 Negatively Regulates Interleukin-3-mediated ERK/Mitogen-activated Protein (MAP) Kinase Activation in Hematopoietic Cells by Nonami, Atsushi, Kato, Reiko, Taniguchi, Koji, Yoshiga, Daigo, Taketomi, Takaharu, Fukuyama, Satoru, Harada, Mine, Sasaki, Atsuo, Yoshimura, Akihiko

“…Sprouty/Spred family proteins have been identified as negative regulators of growth factor-induced ERK/mitogen-activated protein (MAP) kinase activation…”
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Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation by Kato, Reiko, Nonami, Atsushi, Taketomi, Takaharu, Wakioka, Toru, Kuroiwa, Asato, Matsuda, Yoichi, Yoshimura, Akihiko

“…We have reported on Spred-1 and Spred-2, which inhibit MAP kinase activation by interacting with c-kit and ras/raf. Here, we report the cloning of a third…”
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Successful treatment of parainfluenza virus 3 pneumonia with oral ribavirin and methylprednisolone in a bone marrow transplant recipient by Shima, Takahiro, Yoshimoto, Goichi, Nonami, Atsushi, Yoshida, Shuro, Kamezaki, Kenjiro, Iwasaki, Hiromi, Takenaka, Katsuto, Miyamoto, Toshihiro, Harada, Naoki, Teshima, Takanori, Akashi, Koichi, Nagafuji, Koji

“…We report a case of severe parainfluenza (PIV) 3 pneumonia in a hematopoietic stem cell transplant recipient that was successfully treated with oral ribavirin…”
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Successful Treatment of Myelodysplastic Syndrome (MDS)-related intestinal Behçet's Disease by Up-front Cord Blood Transplantation by Nonami, Atsushi, Takenaka, Katsuto, Sumida, Chinatsu, Aizawa, Kumiko, Kamezaki, Kenjiro, Miyamoto, Toshihiro, Harada, Naoki, Nagafuji, Koji, Teshima, Takanori, Harada, Mine

“…Behçet's disease is a chronic, relapsing, inflammatory disease of unknown origin. The association of myelodysplastic syndrome and Behçet's disease is rare, and…”
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Toxoplasmosis encephalitis following severe graft-vs.-host disease after allogeneic hematopoietic stem cell transplantation: 17 yr experience in Fukuoka BMT group by Matsuo, Yayoi, Takeishi, Shoichiro, Miyamoto, Toshihiro, Nonami, Atsushi, Kikushige, Yoshikane, Kunisaki, Yuya, Kamezaki, Kenjiro, Tu, Liping, Hisaeda, Hajime, Takenaka, Katsuto, Harada, Naoki, Kamimura, Tomohiko, Ohno, Yuju, Eto, Tetsuya, Teshima, Takanori, Gondo, Hisashi, Harada, Mine, Nagafuji, Koji

“…Toxoplasmosis is a rare but rapidly fatal complication that can occur following hematopoietic stem cell transplantation (HSCT). Over a 17‐yr period at our…”
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Successful treatment of primary cardiac lymphoma by rituximab-CHOP and high-dose chemotherapy with autologous peripheral blood stem cell transplantation by NONAMI, Atsushi, TAKENAKA, Katsuto, KAMEZAKI, Kenjiro, MIYAMOTO, Toshihiro, HARADA, Naoki, NAGAFUJI, Koji, TESHIMA, Takanori, HARADA, Mine

“…Primary cardiac lymphoma (PCL) is defined as lymphoma involving only the heart and/or pericardium, or with an intrapericardial location of the main tumor mass…”
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Coordinate Loss of a MicroRNA Mir 145 and a Protein-Coding Gene RPS14 Cooperate in the Pathogenesis of 5q- Syndrome by Kumar, Madhu, Narla, Anupama, Nonami, Atsushi, Ball, Brian, Chin, Christine, Chen, Cindy, Kutok, Jeffery Lorne, Galili, Naomi, Raza, Azra, Attar, Eyal C., GIlliland, D. Gary, Jacks, Tyler, Ebert, Benjamin L.

“…Abstract 947 Large hemizygous chromosomal deletions are among the most common molecular abnormalities in cancer, but the identification of critical…”
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Mammalian Sprouty4 Suppresses Ras-Independent ERK Activation by Binding to Raf1 by Sasaki, Atsuo, Taketomi, Takaharu, Kato, Reiko, Saeki, Kazuko, Nonami, Atsushi, Sasaki, Mika, Kuriyama, Masamitsu, Saito, Naoaki, Shibuya, Masafumi, Yoshimura, Akihiko

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Human Herpes Virus 8-negative Primary Effusion Lymphoma (PEL) in a Patient after Repeated Chylous Ascites and Chylothorax by NONAMI, Atsushi, YOKOYAMA, Toshihiro, TAKESHITA, Morishige, OHSHIMA, Koichi, KUBOTA, Akira, OKAMURA, Seiichi

“…We describe a case of malignant lymphoma which presented in the body cavities without identifiable tumor masses. Malignant lymphoma cells showed strong atypia…”
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