Search Results - "Nomura, Taisei"

A Novel HER3-Targeting Antibody-Drug Conjugate, U3-1402, Exhibits Potent Therapeutic Efficacy through the Delivery of Cytotoxic Payload by Efficient Internalization by Hashimoto, Yuuri, Koyama, Kumiko, Kamai, Yasuki, Hirotani, Kenji, Ogitani, Yusuke, Zembutsu, Akiko, Abe, Manabu, Kaneda, Yuki, Maeda, Naoyuki, Shiose, Yoshinobu, Iguchi, Takuma, Ishizaka, Tomomichi, Karibe, Tsuyoshi, Hayakawa, Ichiro, Morita, Koji, Nakada, Takashi, Nomura, Taisei, Wakita, Kenichi, Kagari, Takashi, Abe, Yuki, Murakami, Masato, Ueno, Suguru, Agatsuma, Toshinori

“…HER3 is a compelling target for cancer treatment; however, no HER3-targeted therapy is currently clinically available. Here, we produced U3-1402, an anti-HER3…”
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High‐throughput screening in colorectal cancer tissue‐originated spheroids by Kondo, Jumpei, Ekawa, Tomoya, Endo, Hiroko, Yamazaki, Kanami, Tanaka, Norio, Kukita, Yoji, Okuyama, Hiroaki, Okami, Jiro, Imamura, Fumio, Ohue, Masayuki, Kato, Kikuya, Nomura, Taisei, Kohara, Arihiro, Mori, Seiichi, Dan, Shingo, Inoue, Masahiro

“…Patient‐derived cancer organoid culture is an important live material that reflects clinical heterogeneity. However, the limited amount of organoids available…”
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Anti-glypican-1 antibody–drug conjugate is a potential therapy against pancreatic cancer by Nishigaki, Takahiko, Takahashi, Tsuyoshi, Serada, Satoshi, Fujimoto, Minoru, Ohkawara, Tomoharu, Hara, Hisashi, Sugase, Takahito, Otsuru, Toru, Saito, Yurina, Tsujii, Shigehiro, Nomura, Taisei, Tanaka, Koji, Miyazaki, Yasuhiro, Makino, Tomoki, Kurokawa, Yukinori, Nakajima, Kiyokazu, Eguchi, Hidetoshi, Yamasaki, Makoto, Mori, Masaki, Doki, Yuichiro, Naka, Tetsuji

“…Background Pancreatic cancer (PDAC) is the most lethal malignancy. New treatment options for it are urgently required. The aim was to develop an antibody–drug…”
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Glypican-1 Is a Novel Target for Stroma and Tumor Cell Dual-Targeting Antibody-Drug Conjugates in Pancreatic Cancer by Tsujii, Shigehiro, Serada, Satoshi, Fujimoto, Minoru, Uemura, Sunao, Namikawa, Tsutomu, Nomura, Taisei, Murakami, Ichiro, Hanazaki, Kazuhiro, Naka, Tetsuji

“…Pancreatic ductal adenocarcinoma (PDAC) is a stroma-rich cancer. Extracellular matrix proteins produced by cancer-associated fibroblasts (CAFs) found in tumor…”
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Study of glycosylation of prostate-specific antigen secreted by cancer tissue-originated spheroids reveals new candidates for prostate cancer detection by Ideo, Hiroko, Kondo, Jumpei, Nomura, Taisei, Nonomura, Norio, Inoue, Masahiro, Amano, Junko

“…Prostate-specific antigen (PSA) is the most frequently used biomarker for the screening of prostate cancer. Understanding the structure of cancer-specific…”
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A glypican-1-targeted antibody-drug conjugate exhibits potent tumor growth inhibition in glypican-1-positive pancreatic cancer and esophageal squamous cell carcinoma by Munekage, Eri, Serada, Satoshi, Tsujii, Shigehiro, Yokota, Keiichiro, Kiuchi, Keita, Tominaga, Kenji, Fujimoto, Minoru, Kanda, Mizuki, Uemura, Sunao, Namikawa, Tsutomu, Nomura, Taisei, Murakami, Ichiro, Hanazaki, Kazuhiro, Naka, Tetsuji

“…•The authors developed a humanized anti-glypican-1 (GPC1) monoclonal antibody (clone T2) and produced an antibody-drug conjugate (ADC) linked to monomethyl…”
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The Tumor Growth Inhibitory Effect of a Standardized Extract of Cultured Lentinula edodes Mycelia Using Patient Derived Xenograft Model by Yoshii, Remi, Adachi, Shigeki, Ryo, Haruko, Hatanaka, Eiko, Yasuda, Koujun, Kaji, Momoyo, Enomoto, Kumiko, Takanari, Jun, Yoshidome, Katsuhide, Nomura, Taisei, Tomiyama, Noriyuki

“…Patient derived xenograft (PDX) is a powerful tool to confirm pharmacological efficacy in non-clinical studies for the development of various drugs including…”
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Spermatogenesis-associated changes of fucosylated glycolipids in murine testis by Iwamori, Masao, Adachi, Shigeki, Lin, Bei, Tanaka, Kyoko, Aoki, Daisuke, Nomura, Taisei

“…By targeted deletion of either the FUT1 - or FUT2 -gene for α1,2-fucosyltransferase, expression of FGM1 and FGA1, in murine testis was revealed to be sustained…”
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Neutron relative biological effectiveness in Hiroshima and Nagasaki atomic bomb survivors: a critical review by Sasaki, Masao S, Endo, Satoru, Hoshi, Masaharu, Nomura, Taisei

“…The calculated risk of cancer in humans due to radiation exposure is based primarily on long-term follow-up studies, e.g. the life-span study (LSS) on atomic…”
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Absence of lactobacilli containing glycolipids with the α-galactose epitope and the enhanced fucosylation of a receptor glycolipid GA1 in the digestive tracts of immune-deficient scid mice by Iwamori, Masao, Tanaka, Kyoko, Adachi, Shigeki, Aoki, Daisuke, Nomura, Taisei

“…The Lactobacillus species in the digestive tracts of immune-deficient scid mice was distinct from that in control mice, i.e. Lactobacillus murinus in scid and…”
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Changes in bacterial glycolipids as an index of intestinal lactobacilli and epithelial glycolipids in the digestive tracts of mice after administration of penicillin and streptomycin by Iwamori, Masao, Iwamori, Yuriko, Adachi, Shigeki, Nomura, Taisei

“…The major lipid constituent of symbiotic gram-positive bacteria in animals are phosphatidylglycerol, cardiolipin and dihexaosyl diglycerides (DH-DG), whose…”
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Transgenerational carcinogenesis: induction and transmission of genetic alterations and mechanisms of carcinogenesis by Nomura, Taisei

“…Parental exposure, i.e. germ cell exposure to radiation and chemicals, increased the incidence of tumors and malformations in the offspring, and the germ-line…”
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Radioprotectors in Radiotherapy by Nair, C K, Parida, D K, Nomura, T

“…Radiotherapy is the most common modality for treating human cancers. Eighty percent of cancer patients need radiotherapy at some time or other, either for…”
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Transgenerational Effects of Radiation and Chemicals in Mice and Humans by Nomura, Taisei

“…Parental exposure of mice to radiation and chemicals causes a variety of adverse effects (e. g. , tumors, congenital malformations and embryonic deaths) in the…”
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Characterization of novel glycolipid antigens with an α-galactose epitope in lactobacilli detected with rabbit anti-Lactobacillus antisera and occurrence of antibodies against them in human sera by Iwamori, Masao, Sakai, Akihiro, Minamimoto, Norihito, Iwamori, Yuriko, Tanaka, Kyoko, Aoki, Daisuke, Adachi, Shigeki, Nomura, Taisei

“…Anti-Lactobacillus johnsonii (LJ) antisera generated by immunization of rabbits with LJ reacted with glyceroglycolipids in LJ, i.e. dihexaosyl diacylglycerol…”
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Bacterial species-characteristic profiles of molecular species, and the antigenicity of phospholipids and glycolipids in symbiotic Lactobacillus, Staphylococcus and Streptococcus species by Iwamori, Masao, Nakasa, Masanori, Yamazaki, Kentaro, Iwamori, Yuriko, Tanaka, Kyoko, Aoki, Daisuke, Adachi, Shigeki, Nomura, Taisei

“…Human symbiotic bacteria, Lactobacillus reuteri (LR) in the intestines, Staphylococcus epidermidis (SE) in skin and Streptococcus salivalis (SS) in the oral…”
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Transgenerational effects of radiation on cancer and other disorders in mice and humans by Taisei Nomura, Larisa S Baleva, Haruko Ryo, Shigeki Adachi, Alla E Sipyagina, Natalya M Karakhan

“…Parental exposure of mice to radiation and chemicals causes a variety of adverse effects in the progeny, and the tumor-susceptibility phenotype is…”
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Distribution of Receptor Glycolipids for Lactobacilli in Murine Digestive Tract and Production of Antibodies Cross-reactive with them by Immunization of Rabbits with Lactobacilli by Iwamori, Masao, Shibagaki, Takahiro, Nakata, Yoshiyuki, Adachi, Shigeki, Nomura, Taisei

“…In the digestive tract of mice (HR-1 strain), glycolipids belonging to the ganglio-series were revealed to be expressed in region-specific manners, i.e. FGA1…”
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Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line by Kumagai, Ayako, Fujita, Akira, Yokoyama, Tomoki, Nonobe, Yuki, Hasaba, Yasuhiro, Sasaki, Tsutomu, Itoh, Yumi, Koura, Minako, Suzuki, Osamu, Adachi, Shigeki, Ryo, Haruko, Kohara, Arihiro, Tripathi, Lokesh P, Sanosaka, Masato, Fukushima, Toshiki, Takahashi, Hiroyuki, Kitagawa, Kazuo, Nagaoka, Yasuo, Kawahara, Hidehisa, Mizuguchi, Kenji, Nomura, Taisei, Matsuda, Junichiro, Tabata, Toshihide, Takemori, Hiroshi

“…Memantine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, and is an approved drug for the treatment of moderate-to-severe…”
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Transforming growth factor-β3 promotes mesenchymal cell proliferation and angiogenesis mediated by the enhancement of cyclin D1, Flk-1, and CD31 gene expression during CL/Fr mouse lip fusion by Muraoka, Noriko, Shum, Lillian, Fukumoto, Satoshi, Nomura, Taisei, Ohishi, Masamichi, Nonaka, Kazuaki

“…BACKGROUND Cleft lip with or without cleft palate is the most common congenital anomaly in the craniofacial region. Knowledge of the molecular mechanisms…”
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