Search Results - "Nomura, Sumihiro"

Renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for new anti-diabetic agent by Nomura, Sumihiro

“…Plasma glucose is continuously filtered through the glomerulus and then is reabsorbed via the transcellular transport system of proximal tubules in the kidney…”
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Synthesis and Biological Evaluation of Thiophene-C-glucosides as Sodium-Dependent Glucose Cotransporter 2 Inhibitors by Sakamaki, Shigeki, Kawanishi, Eiji, Koga, Yuichi, Yamamoto, Yasuo, Kuriyama, Chiaki, Matsushita, Yasuaki, Ueta, Kiichiro, Nomura, Sumihiro

“…The synthesis and structure–activity relationship (SAR) of thiophene-C-glucosides have been explored, and the human sodium-dependent glucose cotransporter 2…”
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Discovery of Canagliflozin, a Novel C-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus by Nomura, Sumihiro, Sakamaki, Shigeki, Hongu, Mitsuya, Kawanishi, Eiji, Koga, Yuichi, Sakamoto, Toshiaki, Yamamoto, Yasuo, Ueta, Kiichiro, Kimata, Hirotaka, Nakayama, Keiko, Tsuda-Tsukimoto, Minoru

“…We discovered that C-glucosides 4 bearing a heteroaromatic ring formed metabolically more stable inhibitors for sodium-dependent glucose cotransporter 2…”
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Stereoselective synthesis of six- and seven-membered ether rings based on the ring expansion by Nakata, Tadashi, Nomura, Sumihiro, Matsukura, Hiroko

“…Six- and seven-membered ether rings were stereoselectively synthesized based on the rearrangement of the cyclic ether with the simultaneous ring expansion…”
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Aryl-β-C-glucosidation using glucal boronate: application to the synthesis of tri-O-methylnorbergenin by Sakamaki, Shigeki, Kawanishi, Eiji, Nomura, Sumihiro, Ishikawa, Tsutomu

“…Novel aryl-β-C-glucosidation method using glucal boronate was developed. This protocol can offer several advantages including use of non-toxic, easily handling…”
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Functionalized aryl-β-C-glycoside synthesis by Barbier-type reaction using 2,4,6-triisopropylphenyllithium by Ohba, Kiyomi, Koga, Yuichi, Nomura, Sumihiro, Nakata, Masaya

“…[Display omitted] We developed an efficient synthetic route for functionalized aryl-β-C-glycosides, which are difficult to prepare by conventional methods. An…”
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Practical Synthesis of (20S)-10-(3-Aminopropyloxy)-7-ethylcamptothecin, a Water-Soluble Analogue of Camptothecin by Watanabe, Tatsuya, Tsuboi, Yasunori, Nomura, Sumihiro

“…A robust, practical synthesis of (20S)‐10‐(3‐aminopropyloxy)‐7‐ethylcamptothecin (T‐2513, 5), which is a water‐soluble analogue of camptothecin, has been…”
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N-glucosides as human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitors by Yamamoto, Yasuo, Kawanishi, Eiji, Koga, Yuichi, Sakamaki, Shigeki, Sakamoto, Toshiaki, Ueta, Kiichiro, Matsushita, Yasuaki, Kuriyama, Chiaki, Tsuda-Tsukimoto, Minoru, Nomura, Sumihiro

“…A series of N-glucosides was synthesized for biological evaluation as human hSGLT2 inhibitors. Compound 9d possessing an indole core structure showed good in…”
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Aryl-I2-C-glucosidation using glucal boronate: application to the synthesis of tri-O-methylnorbergenin by Sakamaki, Shigeki, Kawanishi, Eiji, Nomura, Sumihiro, Ishikawa, Tsutomu

“…Novel aryl-I2-C-glucosidation method using glucal boronate was developed. This protocol can offer several advantages including use of non-toxic, easily…”
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STEREOSELECTIVE SYNTHESIS OF THE S- AND Y-RING SYSTEMS OF MAITOTOXIN by NAKATA, Tadashi, NOMURA, Sumihiro, MATSUKURA, Hiroko

“…The seven-membered S- and Y-ring systems of maitotoxin (1) were stereoselectively synthesized based on the rearrangement-ring expansion of the six-membered…”
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C-Glucosides with heteroaryl thiophene as novel sodium-dependent glucose cotransporter 2 inhibitors by Koga, Yuichi, Sakamaki, Shigeki, Hongu, Mitsuya, Kawanishi, Eiji, Sakamoto, Toshiaki, Yamamoto, Yasuo, Kimata, Hirotaka, Nakayama, Keiko, Kuriyama, Chiaki, Matsushita, Yasuaki, Ueta, Kiichiro, Tsuda-Tsukimoto, Minoru, Nomura, Sumihiro

“…Canagliflozin (1), a novel inhibitor for sodium-dependent glucose cotransporter 2 (SGLT2), has been developed for the treatment of type 2 diabetes. To…”
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Novel Indole‑N‑glucoside, TA-1887 As a Sodium Glucose Cotransporter 2 Inhibitor for Treatment of Type 2 Diabetes by Nomura, Sumihiro, Yamamoto, Yasuo, Matsumura, Yosuke, Ohba, Kiyomi, Sakamaki, Shigeki, Kimata, Hirotaka, Nakayama, Keiko, Kuriyama, Chiaki, Matsushita, Yasuaki, Ueta, Kiichiro, Tsuda-Tsukimoto, Minoru

“…Inhibition of the renal sodium glucose cotransporter (SGLT) increases urinary glucose excretion (UGE) and thus reduces blood glucose levels during…”
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Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist by Sircar, Ila, Gudmundsson, Kristjan S, Martin, Richard, Liang, Jimmy, Nomura, Sumihiro, Jayakumar, Honnappa, Teegarden, Bradley R, Nowlin, Dawn M, Cardarelli, Pina M, Mah, Jason R, Connell, Samuel, Griffith, Ronald C, Lazarides, Elias

“…alpha(4)beta(1) and alpha(4)beta(7) integrins are key regulators of physiologic and pathologic responses in inflammation and autoimmune disease. The…”
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Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: Discovery of TR-14035, a dual α4β7/α4β1 integrin antagonist by SIRCAR, Ila, GUDMUNDSSON, Kristjan S, CONNELL, Samuel, GRIFFITH, Ronald C, LAZARIDES, Elias, MARTIN, Richard, LIANG, Jimmy, NOMURA, Sumihiro, JAYAKUMAR, Honnappa, TEEGARDEN, Bradley R, NOWLIN, Dawn M, CARDARELLI, Pina M, MAH, Jason R

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Stereoselective synthesis of the C- and CD-ring systems of hemibrevetoxin B by Nakata, Tadashi, Nomura, Sumihiro, Matsukura, Hiroko, Morimoto, Masamichi

“…The 7, 7-membered CD ring system of hemibrevetoxin B was stereoselectively synthesized. The crucial steps involve the Sharpless asymmetric epoxidation,…”
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Synthesis and SAR of N-Benzoyl- l-Biphenylalanine Derivatives: Discovery of TR-14035, A Dual α 4β 7/α 4β 1 Integrin Antagonist by Sircar, Ila, Gudmundsson, Kristjan S, Martin, Richard, Liang, Jimmy, Nomura, Sumihiro, Jayakumar, Honnappa, Teegarden, Bradley R, Nowlin, Dawn M, Cardarelli, Pina M, Mah, Jason R, Connell, Samuel, Griffith, Ronald C, Lazarides, Elias

“…α 4β 1 and α 4β 7 integrins are key regulators of physiologic and pathologic responses in inflammation and autoimmune disease. The effectiveness of…”
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Synthesi of Aminobenzo[b]pyrrolizinone and Aminobenzo[b]indolizinone Derivatives by Sato, Yasuhiko, Taga, Masanao, Ohtsuka, Hisao, Inoue, Isao, Kawaguchi, Takayuki, Nomura, Sumihiro, Yamada, Koichiro, Date, Tadamasa, Hiramatsu, Hajime

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Unusual rearrangement reaction of quebrachamine derivative catalyzed by cyanide anion by YOSHIDA, K, NOMURA, S, NISHIBATA, Y, BAN, Y

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