Search Results - "Nomura, Hiroaki"
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Effects of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptors antagonist, in a guinea pig model of asthma
Published in European journal of pharmacology (15-10-2015)“…We assessed in this study the anti-asthmatic effects of ONO-6950, a novel cysteinyl leukotriene 1 (CysLT1) and 2 (CysLT2) receptors dual antagonist, in normal…”
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Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma
Published in Journal of medicinal chemistry (13-08-2015)“…An orally active dual CysLT1 and CysLT2 antagonist possessing a distinctive structure which consists of triple bond and dicarboxylic acid moieties is…”
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Effects of a prostagrandin EP4-receptor agonist ONO-AE1-329 on the left ventricular pressure-volume relationship in the halothane-anesthetized dogs
Published in European journal of pharmacology (15-03-2016)“…Cardiac effects of a prostagrandin EP4-receptor agonist ONO-AE1-329 were assessed in the halothane-anesthetized dogs under the monitoring of left ventricular…”
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Cardiohemodynamic and electrophysiological effects of a selective EP4 receptor agonist ONO-AE1-329 in the halothane-anesthetized dogs
Published in European journal of pharmacology (15-08-2015)“…Cardiovascular effects of a highly selective prostaglandin E2 type 4 (EP4) receptor agonist ONO-AE1-329 were assessed with the halothane-anesthetized dogs…”
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Brain 5α-Dihydroprogesterone and Allopregnanolone Synthesis in a Mouse Model of Protracted Social Isolation
Published in Proceedings of the National Academy of Sciences - PNAS (27-02-2001)“…Allopregnanolone (ALLO), is a brain endogenous neurosteroid that binds with high affinity to γ-aminobutyric acid type A (GABAA) receptors and positively…”
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Influences of pyrexia and age on theophylline clearance in young children with asthma
Published in Hiroshima journal of medical sciences (01-03-2012)“…Fifty hospitalized children with asthmatic bronchitis and bronchial asthma were treated with a continuous intravenous drip infusion of aminophylline. To…”
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Novel and stereoselective methods for the preparation of aromatic lactams via reductive coupling reactions mediated by SmI2
Published in Tetrahedron letters (11-03-2000)Get full text
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Multiple Intracranial Seeding of Craniopharyngioma After Repeated Surgery: Case Report
Published in Neurologia medico-chirurgica (2002)“…A 17-year-old woman presented with a rare case of intracranial seeding of craniopharyngioma after repeated surgery. She initially presented with secondary…”
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CV-3988 - a specific antagonist of platelet activating factor (PAF)
Published in Life sciences (1973) (25-04-1983)“…CV-3988, rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl phosphate was shown to be a specific inhibitor of platelet activating factor (PAF)…”
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Discovery of Gemilukast (ONO-6950), a Dual CysLT 1 and CysLT 2 Antagonist As a Therapeutic Agent for Asthma
Published in Journal of medicinal chemistry (13-08-2015)Get full text
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Speech waveform recovery from a reverberant speech signal using inverse filtering of the power envelope transfer function
Published in Electronics & communications in Japan. Part 3, Fundamental electronic science (01-06-2000)“…Research on recovering the sound source waveform from signals observed in a room with reverberation is important for diagnosis of mechanical failure and…”
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Endovascular treatment of a ruptured aneurysm associated with unilateral moyamoya disease
Published in Nō shinkei geka (01-02-2004)“…We report a case presenting with subarachnoid hemorrhage due to a ruptured aneurysm associated with unilateral moyamoya disease. The patient was a 29-year-old…”
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Inhibition of Proliferation and Induction of Differentiation of Human and Mouse Myeloid Leukemia Cells by New Ethyleneglycol‐type Nonphosphorus Alkyl Ether Lipids
Published in Japanese Journal of Cancer Research (01-08-1990)“…A variety of ethyleneglycol‐type nonphosphorus alkyl ether lipids, ether derivatives of diethylene‐glycol in which the two hydroxyl groups were substituted…”
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Primary Choroid Plexus Papilloma of the Foramen Magnum —Case Report
Published in Neurologia medico-chirurgica (1997)“…A 50-year-old male presented with a choroid plexus papilloma in the foramen magnum manifesting as dysesthesia in the right hand and severe headache. Magnetic…”
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Perception of Sound Source Distance and Loudness in a Coherent Field of a Reverberant Field
Published in The Journal of the Acoustical Society of America (01-05-2008)“…Perception of reverberant sound field changes with a sound source distance (SSD). This article describes SSD perception in a coherent region close to the sound…”
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Long-term social isolation enhances picrotoxin seizure susceptibility in mice: up-regulatory role of endogenous brain allopregnanolone in GABAergic systems
Published in Pharmacology, biochemistry and behavior (01-07-2003)“…Allopregnanolone (ALLO, 3α,5α-tetrahydroprogesterone), a positive allosteric modulator of actions of γ-aminobutyric acid GABA) at GABA A receptors, is…”
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Activation of guinea pig peritoneal macrophages by platelet activating factor (PAF) and its agonists
Published in Journal of biochemistry (Tokyo) (01-01-1985)“…The platelet activating factor (PAF: 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine) and its analogs were examined to determine their effects on guinea pig…”
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Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes
Published in Journal of biochemistry (Tokyo) (01-04-1985)“…The phospholipid mediator, platelet activating factor (PAF: 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine), was recently reported to activate…”
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Synthesis and Antitumor Activity of New Alkylphospholipids Containing Modifications of the Phosphocholine Moiety
Published in Chemical & pharmaceutical bulletin (1989)“…New antitumor alkylglycerophospholipids, in which primarily the phosphocholine moiety of the platelet activating factor (PAF) molecule was modified, were…”
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