Search Results - "Nomeir, A."

The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America by GRIMM, Scott W, EINOLF, Heidi J, TONN, George R, VAN HORN, Robert, WANG, Regina W, WONG, Y. Nancy, YANG, Tian J, OBACH, R. Scott, HALL, Steven D, KAN HE, LIM, Heng-Keang, LING, Kah-Hiing John, CHUANG LU, NOMEIR, Amin A, SEIBERT, Eleanore, SKORDOS, Konstantine W

“…Time-dependent inhibition (TDI) of cytochrome P450 (P450) enzymes caused by new molecular entities (NMEs) is of concern because such compounds can be…”
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The Pathogenesis of Acute Pulmonary Edema Associated with Hypertension by Gandhi, Sanjay K, Powers, John C, Nomeir, Abdel-Mohsen, Fowle, Karen, Kitzman, Dalane W, Rankin, Kevin M, Little, William C

“…It is a clinical paradox that patients hospitalized with congestive heart failure may later be noted to have normal systolic function, as evidenced by a normal…”
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Permeability of lipophilic compounds in drug discovery using in-vitro human absorption model, Caco-2 by Krishna, Gopal, Chen, Kwang-jong, Lin, Chin-chung, Nomeir, Amin A

“…Highly lipophilic compounds are often encountered in the early stages of drug discovery. The apparent permeability (Papp) of these compounds in Caco-2 cell…”
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Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice by Reich, Eva‐Pia, Cui, Long, Yang, Lily, Pugliese‐Sivo, Catherine, Golovko, Andrei, Petro, Mary, Vassileva, Galya, Chu, Inhou, Nomeir, Amin A., Zhang, Li‐Kang, Liang, Xian, Kozlowski, Joseph A., Narula, Satwant K., Zavodny, Paul J., Chou, Chuan‐Chu

“…The KCNN4 potassium‐ion channel has been reported to play an important role in regulating antigen‐induced T cell effector functions in vitro. This study…”
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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice by MING LIU, BRYANT, M. S, DELL, J, SINHA, D, SYED, J, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, WANG, L, TAVERAS, A. G, DOLL, R. J, NJOROGE, F. G, JIANPING CHEN, MALLAMS, A. K, REMISZEWSKI, S, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, SUINING LEE, YAREMKO, B, LIPARI, P, MALKOWSKI, M, FERRARI, E, NIELSEN, L, PRIOLI, N

“…We have been developing a series of nonpeptidic, small molecule farnesyl protein transferase inhibitors that share a common tricyclic nucleus and compete with…”
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Development and Validation of an LC-MS-MS Method for the Simultaneous Determination of Sulforaphane and its Metabolites in Rat Plasma and its Application in Pharmacokinetic Studies by Wang, Hu, Lin, Wen, Shen, Guoxiang, Nomeir, Amin A., Khor, Tin-Oo, Kong, Ah-Ng

“…A highly sensitive and simple high-performance liquid chromatographic-tandem mass spectrometric (LC-MS-MS) assay is developed and validated for the…”
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Estimation of the extent of oral absorption in animals from oral and intravenous pharmacokinetic data in drug discovery by Nomeir, Amin A, Morrison, Richard, Prelusky, Daniel, Korfmacher, Walter, Broske, Lisa, Hesk, David, McNamara, Paul, Mei, Hong

“…Oral administration is the most desirable route of drug delivery for systemically active drugs. Oral drugs must possess a certain level of oral…”
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Pharmacokinetics of SCH 56592, a New Azole Broad-Spectrum Antifungal Agent, in Mice, Rats, Rabbits, Dogs, and Cynomolgus Monkeys by NOMEIR, A. A, KUMARI, P, HILBERT, M. J, GUPTA, S, LOEBENBERG, D, CACCIAPUOTI, A, HARE, R, MILLER, G. H, LIN, C.-C, CAYEN, M. N

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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IN VIVO AND IN VITRO EFFICACY OF NIGELLA SATIVA AQUEOUS EXTRACT ON BLASTOCYSTIS HOMINIS by Eida, Omima M, El-Shafei, Hanaa A, Nomeir, Yousra A, El Safhi, Mohammed B

“…Metronidazole (MTZ) was the most widely accepted treatment for Blastocystis hominis (B. hominis) with high treatment failure rate, resistance and potential…”
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High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma by Kim, Hong, Likhari, Paul, Parker, Donald, Statkevich, Paul, Marco, Aliceann, Lin, Chin-Chung, Nomeir, Amin A.

“…Temozolomide (SCH 52365; TEMODAL™) is an antineoplastic agent with activity against a broad spectrum of murine tumors. This compound is currently marketed in…”
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Inhibition of CYP3A4 in a Rapid Microtiter Plate Assay Using Recombinant Enzyme and in Human Liver Microsomes Using Conventional Substrates by NOMEIR, Amin A, RUEGG, Charles, SHOEMAKER, Matthew, FAVREAU, Leonard V, PALAMANDA, Jairam R, SILBER, Paul, LIN, Chin-Chung

“…Cytochrome P450 inhibition studies are performed in the pharmaceutical industry in the discovery stage to screen candidates that may have the potential for…”
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Higher-throughput screening for Caco-2 permeability utilizing a multiple sprayer liquid chromatography/tandem mass spectrometry system by Fung, Eliza N., Chu, Inhou, Li, Cheng, Liu, Tongtong, Soares, Anthony, Morrison, Richard, Nomeir, Amin A.

“…In the current drug discovery environment, higher‐throughput analytical assays have become essential to keep pace with the screening demands for drug…”
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Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity by Coburn, Craig A., Meinke, Peter T., Chang, Wei, Fandozzi, Christine M., Graham, Donald J., Hu, Bin, Huang, Qian, Kargman, Stacia, Kozlowski, Joseph, Liu, Rong, McCauley, John A., Nomeir, Amin A., Soll, Richard M., Vacca, Joseph P., Wang, Dahai, Wu, Hao, Zhong, Bin, Olsen, David B., Ludmerer, Steven W.

“…The NS5A protein plays a critical role in the replication of HCV and has been the focus of numerous research efforts over the past few years. NS5A inhibitors…”
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Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats by Cox, Kathleen A., Dunn-Meynell, Kimberly, Korfmacher, Walter A., Broske, Lisa, Nomeir, Amin A., Lin, Chin-Chung, Cayen, Mitchell N., Barr, William H.

“…In therapeutic areas aimed at developing an orally administered drug, the pharmacokinetic profile of a drug candidate after oral administration in vivo is…”
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Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions by Shue, Ho-Jane, Chen, Xiao, Schwerdt, John H, Paliwal, Sunil, Blythin, David J, Lin, Ling, Gu, Danlin, Wang, Cheng, Reichard, Gregory A, Wang, Hongwu, Piwinski, John J, Duffy, Ruth A, Lachowicz, Jean E, Coffin, Vicki L, Nomeir, Amin A, Morgan, Cynthia A, Varty, Geoffrey B, Shih, Neng-Yang

“…A series of novel five-membered urea derivatives as potent NK1 receptor antagonists is described. The effects of substitution of a 4-fluoro group at the phenyl…”
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Use of high-performance liquid chromatographic and microbiological analyses for evaluating the presence or absence of active metabolites of the antifungal posaconazole in human plasma by Kim, Hong, Kumari, Pramila, Laughlin, Mark, Hilbert, Mary Jane, Indelicato, Stephen R, Lim, Josephine, Lin, Chin-Chung, Nomeir, Amin A

“…Posaconazole (SCH 56592) is a novel broad spectrum triazole antifungal agent that is currently in phase III clinical trials for the treatment of systemic…”
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In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects by Cohen-Williams, Mary E., Leach, Prescott T., Del Vecchio, Robert A., Zhang, Qi, Hyde, Lynn A., Chen, Lei, Wong, Gwendolyn T., McHugh, Nansie A., Chen, Joseph, Higgins, Guy A., Asberom, Theodros, Li, Wei, Pissarnitski, Dmitri, Levitan, Diane, Nomeir, Amin A., Clader, John W., Zhang, Lili, Parker, Eric M.

“…Substantial evidence implicates β-amyloid (Aβ) peptides in the etiology of Alzheimer’s disease (AD). Aβ is produced by the proteolytic cleavage of the amyloid…”
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Cyclic urea derivatives as potent NK1 selective antagonists by SHUE, Ho-Jane, XIAO CHEN, PIWINSKI, John J, DUFFY, Ruth A, LACHOWICZ, Jean E, COFFIN, Vicki L, FEI LIU, NOMEIR, Amin A, MORGAN, Cynthia A, VARTY, Geoffrey B, SHIH, Neng-Yang, BLYTHIN, David J, PALIWAL, Sunil, LING LIN, DANLIN GU, SCHWERDT, John H, SHAH, Sapna, REICHARD, Gregory A

“…A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this…”
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Validation of a rapid microtiter plate assay to conduct cytochrome P450 2D6 enzyme inhibition studies by Palamanda, Jairam R, Favreau, Leonard, Lin, Chin-chung, Nomeir, Amin A

“…Cytochrome P450 (CYP) inhibition studies are often performed on new chemical entities during the drug discovery stage. However, advances in combinatorial…”
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In Vivo Characterization of a Novel -Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects by Hyde, Lynn A., Zhang, Qi, Del Vecchio, Robert A., Leach, Prescott T., Cohen-Williams, Mary E., Chen, Lei, Wong, Gwendolyn T., McHugh, Nansie A., Chen, Joseph, Higgins, Guy A., Asberom, Theodros, Li, Wei, Pissarnitski, Dmitri, Levitan, Diane, Nomeir, Amin A., Clader, John W., Zhang, Lili, Parker, Eric M.

“…Substantial evidence implicates -amyloid (A) peptides in the etiology of Alzheimer’s disease (AD). A is produced by the proteolytic cleavage of the amyloid…”
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