Search Results - "Nolte, Whitney M."

Autophagy and the Immune System by Kuballa, Petric, Nolte, Whitney M, Castoreno, Adam B, Xavier, Ramnik J

“…Stressors ranging from nutrient deprivation to immune signaling can induce the degradation of cytoplasmic material by a process known as autophagy…”
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A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification by Nolte, Whitney M, Fortin, Jean-Philippe, Stevens, Benjamin D, Aspnes, Gary E, Griffith, David A, Hoth, Lise R, Ruggeri, Roger B, Mathiowetz, Alan M, Limberakis, Chris, Hepworth, David, Carpino, Philip A

“…BETP, a positive allosteric modulator of GLP-1R, a class B GPCR and an important therapeutic target for type II diabetes, covalently modifies two cysteine…”
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Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides by Kim, Yun-Gon, Lone, Anna Mari, Nolte, Whitney M, Saghatelian, Alan

“…Peptide hormones and neuropeptides have important roles in physiology and therefore the regulation of these bioactive peptides is of great interest. In some…”
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Peptidase substrates via global peptide profiling by Tagore, Debarati M, Nolte, Whitney M, Neveu, John M, Rangel, Roberto, Guzman-Rojas, Liliana, Pasqualini, Renata, Arap, Wadih, Lane, William S, Saghatelian, Alan

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Screening trimethoprim primary metabolites for covalent binding to albumin by Nolte, Whitney M., Tessman, Robert T., Goldman, Jennifer L.

“…Modification of endogenous proteins by drugs and drug metabolites are thought to be a cause of idiosyncratic adverse drug reactions (IADRs). Trimethoprim (TMP)…”
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Peptidomics of Prolyl Endopeptidase in the Central Nervous System by Nolte, Whitney M, Tagore, Debarati M, Lane, William S, Saghatelian, Alan

“…Prolyl endopeptidase (Prep) is a member of the prolyl peptidase family and is of interest because of its unique biochemistry and connections to cognitive…”
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Peptidomics of the Prolyl Peptidases by Lone, Anna Mari, Nolte, Whitney M., Tinoco, Arthur D., Saghatelian, Alan

“…The prolyl peptidases are a family of enzymes characterized by a biochemical preference for cleaving proline-containing peptides. The members of this enzyme…”
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Controlled Modulation of Conductance in Silicon Devices by Molecular Monolayers by He, Tao, He, Jianli, Lu, Meng, Chen, Bo, Pang, Harry, Reus, William F, Nolte, Whitney M, Nackashi, David P, Franzon, Paul D, Tour, James M

“…We have controllably modulated the drain current (I D) and threshold voltage (V T) in pseudo metal-oxide-semiconductor field-effect transistors (MOSFETs) by…”
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Peptidase substrates via global peptide profiling by Saghatelian, Alan, Tagore, Debarati M, Nolte, Whitney M, Neveu, John M, Rangel, Roberto, Guzman-Rojas, Liliana, Pasqualini, Renata, Arap, Wadih, Lane, William S

“…Peptide metabolism is a complex process that involves many proteins working in concert. Mass spectrometry-based global peptide profiling of mice lacking…”
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Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor by Eng, Heather, Sharma, Raman, McDonald, Thomas S, Edmonds, David J, Fortin, Jean-Philippe, Li, Xianping, Stevens, Benjamin D, Griffith, David A, Limberakis, Chris, Nolte, Whitney M, Price, David A, Jackson, Margaret, Kalgutkar, Amit S

“…4-(3-(Benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP) represents a novel small-molecule activator of the glucagon-like peptide-1…”
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Direct Covalent Grafting of Polyoxometalates onto Si Surfaces by Lu, Meng, Nolte, Whitney M., He, Tao, Corley, David A., Tour, James M.

“…A diazonium salt-derived organoimido hexamolybdate was synthesized and directly covalently immobilized on Si surfaces using diazonium chemistry to form both…”
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