Search Results - "Nolte, Whitney"

Autophagy and the Immune System by Kuballa, Petric, Nolte, Whitney M, Castoreno, Adam B, Xavier, Ramnik J

“…Stressors ranging from nutrient deprivation to immune signaling can induce the degradation of cytoplasmic material by a process known as autophagy…”
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A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification by Nolte, Whitney M, Fortin, Jean-Philippe, Stevens, Benjamin D, Aspnes, Gary E, Griffith, David A, Hoth, Lise R, Ruggeri, Roger B, Mathiowetz, Alan M, Limberakis, Chris, Hepworth, David, Carpino, Philip A

“…BETP, a positive allosteric modulator of GLP-1R, a class B GPCR and an important therapeutic target for type II diabetes, covalently modifies two cysteine…”
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P168 - Methods to detect and enrich trimethoprim protein adducts in biological matrices by Nolte, Whitney, Preuett, Barry, Goldman, Jennifer

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Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides by Kim, Yun-Gon, Lone, Anna Mari, Nolte, Whitney M, Saghatelian, Alan

“…Peptide hormones and neuropeptides have important roles in physiology and therefore the regulation of these bioactive peptides is of great interest. In some…”
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Screening trimethoprim primary metabolites for covalent binding to albumin by Nolte, Whitney M., Tessman, Robert T., Goldman, Jennifer L.

“…Modification of endogenous proteins by drugs and drug metabolites are thought to be a cause of idiosyncratic adverse drug reactions (IADRs). Trimethoprim (TMP)…”
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Effects of genotype and food on naltrexone exposure in adolescents by Stancil, Stephani L., Voss, Michaela, Nolte, Whitney, Tumberger, John, Adelman, William, Abdel‐Rahman, Susan

“…Naltrexone (NTX), an opioid antagonist metabolized by aldo‐keto reductase 1C4 (AKR1C4), is prescribed for psychiatric conditions like eating disorders with…”
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Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life by Krzyzanski, Wojciech, Stockard, Bradley, Gaedigk, Andrea, Scott, Allison, Nolte, Whitney, Gibson, Kim, Leeder, J. Steven, Lewis, Tamorah

“…Indomethacin is used commonly in preterm neonates for the prevention of intracranial hemorrhage and closure of an abnormally open cardiac vessel. Due to…”
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Direct Covalent Grafting of Polyoxometalates onto Si Surfaces by Lu, Meng, Nolte, Whitney M., He, Tao, Corley, David A., Tour, James M.

“…A diazonium salt-derived organoimido hexamolybdate was synthesized and directly covalently immobilized on Si surfaces using diazonium chemistry to form both…”
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Peptidomics of Prolyl Endopeptidase in the Central Nervous System by Nolte, Whitney M, Tagore, Debarati M, Lane, William S, Saghatelian, Alan

“…Prolyl endopeptidase (Prep) is a member of the prolyl peptidase family and is of interest because of its unique biochemistry and connections to cognitive…”
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Peptidomics of the Prolyl Peptidases by Lone, Anna Mari, Nolte, Whitney M., Tinoco, Arthur D., Saghatelian, Alan

“…The prolyl peptidases are a family of enzymes characterized by a biochemical preference for cleaving proline-containing peptides. The members of this enzyme…”
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Controlled Modulation of Conductance in Silicon Devices by Molecular Monolayers by He, Tao, He, Jianli, Lu, Meng, Chen, Bo, Pang, Harry, Reus, William F, Nolte, Whitney M, Nackashi, David P, Franzon, Paul D, Tour, James M

“…We have controllably modulated the drain current (I D) and threshold voltage (V T) in pseudo metal-oxide-semiconductor field-effect transistors (MOSFETs) by…”
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Peptidase substrates via global peptide profiling by Saghatelian, Alan, Tagore, Debarati M, Nolte, Whitney M, Neveu, John M, Rangel, Roberto, Guzman-Rojas, Liliana, Pasqualini, Renata, Arap, Wadih, Lane, William S

“…Peptide metabolism is a complex process that involves many proteins working in concert. Mass spectrometry-based global peptide profiling of mice lacking…”
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Photodegradation of Congo Red catalyzed by nanosized TiO2 by WAHI, Rajeev K, YU, William W, YUNPING LIU, MEJIA, Michelle L, FALKNER, Joshua C, NOLTE, Whitney, COLVIN, Vicki L

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Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor by Eng, Heather, Sharma, Raman, McDonald, Thomas S, Edmonds, David J, Fortin, Jean-Philippe, Li, Xianping, Stevens, Benjamin D, Griffith, David A, Limberakis, Chris, Nolte, Whitney M, Price, David A, Jackson, Margaret, Kalgutkar, Amit S

“…4-(3-(Benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP) represents a novel small-molecule activator of the glucagon-like peptide-1…”
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Peptidase substrates via global peptide profiling by Tagore, Debarati M, Nolte, Whitney M, Neveu, John M, Rangel, Roberto, Guzman-Rojas, Liliana, Pasqualini, Renata, Arap, Wadih, Lane, William S, Saghatelian, Alan

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A GLP‐1R Positive Allosteric Modulator Acts through Covalent Modification by Nolte, Whitney

“…Abstract only The glucagon‐like peptide‐1 receptor (GLP‐1R) is an important target for the treatment of type 2 diabetes. Recent studies have identified several…”
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Simultaneous quantification of trimethoprim metabolites in pediatric plasma by Tessman, Robert T., Nolte, Whitney, Toren, Paul, Gibson, Kim, Vu, Linda, Goldman, Jennifer

“…•Efficient workflow allows for rapid quantification of trimethoprim and metabolites.•Human plasma trimethoprim metabolic profiles.•Pediatric study. The dual…”
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The Impact of Age and Genetics on Naltrexone Biotransformation by Stancil, Stephani L, Nolte, Whitney, Pearce, Robin E, Staggs, Vincent S, Leeder, J Steven

“…Naltrexone, an opioid antagonist primarily metabolized by aldo-keto reductase 1C4 (AKR1C4), treats pediatric conditions involving compulsiveness (e.g., autism…”
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Identifying Protease-Peptide Interactions Using Mass Spectrometry by Nolte, Whitney Marie

“…The central role of peptides in physiology has driven research to elucidate the molecular mechanisms that regulate bioactive peptides in vivo. Proteolytic…”
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Photodegradation of Congo Red catalyzed by nanosized TiO 2 by Wahi, Rajeev K., Yu, William W., Liu, Yunping, Mejia, Michelle L., Falkner, Joshua C., Nolte, Whitney, Colvin, Vicki L.

“…Anatase TiO 2 is a superior photocatalyst to rutile TiO 2 due to the inherent difference in the two crystal structures. Anatase TiO 2 nanorods with…”
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