Search Results - "Nolte, Martijn A."

Impact of Viral Infections on Hematopoiesis: From Beneficial to Detrimental Effects on Bone Marrow Output by Pascutti, Maria Fernanda, Erkelens, Martje N, Nolte, Martijn A

“…The ability of the bone marrow (BM) to generate copious amounts of blood cells required on a daily basis depends on a highly orchestrated process of…”
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Inflammatory signals in dendritic cell activation and the induction of adaptive immunity by Joffre, Olivier, Nolte, Martijn A, Spörri, Roman, Sousa, Caetano Reis e

“…Pathogen invasion induces a rapid inflammatory response initiated through the recognition of pathogen-derived molecules by pattern recognition receptors (PRRs)…”
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Functional Heterogeneity of CD4 + Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC by Oja, Anna E, Piet, Berber, van der Zwan, David, Blaauwgeers, Hans, Mensink, Mark, de Kivit, Sander, Borst, Jannie, Nolte, Martijn A, van Lier, René A W, Stark, Regina, Hombrink, Pleun

“…Resident memory T cells (T ) inhabit peripheral tissues and are critical for protection against localized infections. Recently, it has become evident that…”
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The Bone Marrow as Sanctuary for Plasma Cells and Memory T-Cells: Implications for Adaptive Immunity and Vaccinology by Slamanig, Stefan A., Nolte, Martijn A.

“…The bone marrow (BM) is key to protective immunological memory because it harbors a major fraction of the body’s plasma cells, memory CD4+ and memory CD8+…”
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The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues by Vasanthakumar, Ajithkumar, Liao, Yang, Teh, Peggy, Pascutti, Maria F., Oja, Anna E., Garnham, Alexandra L., Gloury, Renee, Tempany, Jessica C., Sidwell, Tom, Cuadrado, Eloy, Tuijnenburg, Paul, Kuijpers, Taco W., Lalaoui, Najoua, Mielke, Lisa A., Bryant, Vanessa L., Hodgkin, Philip D., Silke, John, Smyth, Gordon K., Nolte, Martijn A., Shi, Wei, Kallies, Axel

“…After exiting the thymus, Foxp3+ regulatory T (Treg) cells undergo further differentiation in the periphery, resulting in the generation of mature, fully…”
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Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium by Rademakers, Timo, Goedhart, Marieke, Hoogenboezem, Mark, García Ponce, Alexander, van Rijssel, Jos, Samus, Maryna, Schnoor, Michael, Butz, Stefan, Huveneers, Stephan, Vestweber, Dietmar, Nolte, Martijn A, Voermans, Carlijn, van Buul, Jaap D

“…Bone marrow endothelium plays an important role in the homing of hematopoietic stem and progenitor cells upon transplantation, but surprisingly little is known…”
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The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8 + T Cell Responses of Low Antigen Affinity to Protect against Viral Variants by van Gisbergen, Klaas P.J.M., Klarenbeek, Paul L., Kragten, Natasja A.M., Unger, Peter-Paul A., Nieuwenhuis, Marieke B.B., Wensveen, Felix M., ten Brinke, Anja, Tak, Paul P., Eldering, Eric, Nolte, Martijn A., van Lier, Rene A.W.

“…CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8 + T cells. Here, we show that CD27-driven…”
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Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology by Nolte, Martijn A, van Olffen, Ronald W, van Gisbergen, Klaas P.J.M, van Lier, René A.W

“…After binding its natural ligand cluster of differentiation 70 (CD70), CD27, a tumor necrosis factor receptor (TNFR)-associated factor-binding member of the…”
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Blimp‐1 homolog Hobit identifies effector‐type lymphocytes in humans by Vieira Braga, Felipe A., Hertoghs, Kirsten M. L., Kragten, Natasja A. M., Doody, Gina M., Barnes, Nicholas A., Remmerswaal, Ester B. M., Hsiao, Cheng‐Chih, Moerland, Perry D., Wouters, Diana, Derks, Ingrid A. M., Stijn, Amber, Demkes, Marc, Hamann, Jörg, Eldering, Eric, Nolte, Martijn A., Tooze, Reuben M., ten Berge, Ineke J. M., Gisbergen, Klaas P. J. M., Lier, René A. W.

“…Human cytomegalovirus (CMV) induces the formation of effector CD8+ T cells that are maintained for decades during the latent stage of infection. Effector CD8+…”
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Toll-like receptor 3 promotes cross-priming to virus-infected cells by Reis e Sousa, Caetano, Schulz, Oliver, Diebold, Sandra S, Chen, Margaret, Näslund, Tanja I, Nolte, Martijn A, Alexopoulou, Lena, Azuma, Yasu-Taka, Flavell, Richard A, Liljeström, Peter

“…Cross-presentation of cell-associated antigens plays an important role in regulating CD8+ T cell responses to proteins that are not expressed by…”
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The RhoGEF Trio: A Protein with a Wide Range of Functions in the Vascular Endothelium by Kempers, Lanette, Driessen, Amber J. M., van Rijssel, Jos, Nolte, Martijn A., van Buul, Jaap D.

“…Many cellular processes are controlled by small GTPases, which can be activated by guanine nucleotide exchange factors (GEFs). The RhoGEF Trio contains two GEF…”
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Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins by Rogers, Neil C., Slack, Emma C., Edwards, Alexander D., Nolte, Martijn A., Schulz, Oliver, Schweighoffer, Edina, Williams, David L., Gordon, Siamon, Tybulewicz, Victor L., Brown, Gordon D., Reis e Sousa, Caetano

“…Pattern-recognition receptors (PRRs) detect molecular signatures of microbes and initiate immune responses to infection. Prototypical PRRs such as Toll-like…”
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Code Red in the Supply Center: The Impact of Immune Activation on Hematopoiesis by MacNamara, Katherine C, Nolte, Martijn A

“…This Special Issue entitled "The Impact of Immune Activation on Hematopoiesis" aims to bring together review and primary articles focused on distinct types of…”
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Memory CD8 + T cells support the maintenance of hematopoietic stem cells in the bone marrow by Geerman, Sulima, Brasser, Giso, Bhushal, Sudeep, Salerno, Fiamma, Kragten, Natasja A, Hoogenboezem, Mark, de Haan, Gerald, Wolkers, Monika C, Pascutti, María Fernanda, Nolte, Martijn A

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Quantitative and Qualitative Analysis of Bone Marrow CD8(+) T Cells from Different Bones Uncovers a Major Contribution of the Bone Marrow in the Vertebrae by Geerman, Sulima, Hickson, Sarah, Brasser, Giso, Pascutti, Maria Fernanda, Nolte, Martijn A

“…Bone marrow (BM) plays an important role in the long-term maintenance of memory T cells. Yet, BM is found in numerous bones throughout the body, which are not…”
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Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration by Arts, Janine JG, Mahlandt, Eike K, Grönloh, Max LB, Schimmel, Lilian, Noordstra, Ivar, Gordon, Emma, van Steen, Abraham CI, Tol, Simon, Walzog, Barbara, van Rijssel, Jos, Nolte, Martijn A, Postma, Marten, Khuon, Satya, Heddleston, John M, Wait, Eric, Chew, Teng Leong, Winter, Mark, Montanez, Eloi, Goedhart, Joachim, van Buul, Jaap D

“…Upon inflammation, leukocytes rapidly transmigrate across the endothelium to enter the inflamed tissue. Evidence accumulates that leukocytes use preferred exit…”
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Interferon-Gamma Impairs Maintenance and Alters Hematopoietic Support of Bone Marrow Mesenchymal Stromal Cells by Goedhart, Marieke, Cornelissen, Anne S, Kuijk, Carlijn, Geerman, Sulima, Kleijer, Marion, van Buul, Jaap D, Huveneers, Stephan, Raaijmakers, Marc H G P, Young, Howard A, Wolkers, Monika C, Voermans, Carlijn, Nolte, Martijn A

“…Bone marrow (BM) mesenchymal stromal cells (MSCs) provide microenvironmental support to hematopoietic stem and progenitor cells (HSPCs). Culture-expanded MSCs…”
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Impact of T cells on hematopoietic stem and progenitor cell function: Good guys or bad guys? by Geerman, Sulima, Nolte, Martijn A

“…When hematopoietic stem and progenitor cells (HSPC) are harvested for transplantation, either from the bone marrow or from mobilized blood, the graft contains…”
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Age-Related Variation in Sympathetic Nerve Distribution in the Human Spleen by Cleypool, Cindy G. J., Brinkman, David J., Mackaaij, Claire, Nikkels, Peter G. J., Nolte, Martijn A., Luyer, Misha D., de Jonge, Wouter J., Bleys, Ronald L. A. W.

“…Introduction: The cholinergic anti-inflammatory pathway (CAIP) has been proposed as an efferent neural pathway dampening the systemic inflammatory response via…”
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Primary adhered neutrophils increase JNK1-MARCKSL1-mediated filopodia to promote secondary neutrophil transmigration by Grönloh, Max Laurens Bastiaan, Arts, Janine Johanna Geertruida, Mahlandt, Eike Karin, Nolte, Martijn A., Goedhart, Joachim, van Buul, Jaap Diederik

“…During inflammation, leukocytes extravasate the vasculature to areas of inflammation in a process termed transendothelial migration. Previous research has…”
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