Search Results - "Nollet, Edgar E."

Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling by VuckoviÄ, Sofija, Dinani, Rafeeh, Nollet, Edgar E, Kuster, Diederik W. D, Buikema, Jan Willem, Houtkooper, Riekelt H, Nabben, Miranda, van der Velden, Jolanda, Goversen, Birgit

“…Abstract Background Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have emerged as a powerful tool for disease modeling, though their immature…”
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Large-Scale Contractility Measurements Reveal Large Atrioventricular and Subtle Interventricular Differences in Cultured Unloaded Rat Cardiomyocytes by Nollet, Edgar E., Manders, Emmy M., Goebel, Max, Jansen, Valentijn, Brockmann, Cord, Osinga, Jorrit, van der Velden, Jolanda, Helmes, Michiel, Kuster, Diederik W. D.

“…The chambers of the heart fulfill different hemodynamic functions, which are reflected in their structural and contractile properties. While the atria are…”
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Unraveling the Genotype-Phenotype Relationship in Hypertrophic Cardiomyopathy: Obesity-Related Cardiac Defects as a Major Disease Modifier by Nollet, Edgar E, Westenbrink, B Daan, de Boer, Rudolf A, Kuster, Diederik W D, van der Velden, Jolanda

“…Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and is characterized by asymmetric septal thickening and diastolic dysfunction…”
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The IRAK-M death domain: a tale of three surfaces by Gürkan, Berke, Poelman, Hessel, Pereverzeva, Liza, Kruijswijk, Danielle, de Vos, Alex F, Groenen, Anouk G, Nollet, Edgar E, Wichapong, Kanin, Lutgens, Esther, van der Poll, Tom, Du, Jiangfeng, Wiersinga, W Joost, Nicolaes, Gerry A F, van 't Veer, Cornelis

“…The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also…”
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A safety screening platform for individualized cardiotoxicity assessment by Schwach, Verena, Slaats, Rolf H., Cofiño-Fabres, Carla, ten Den, Simone A., Rivera-Arbeláez, José M., Dannenberg, Maureen, van Boheemen, Chiara, Ribeiro, Marcelo C., van der Zanden, Sabina Y., Nollet, Edgar E., van der Velden, Jolanda, Neefjes, Jacques, Cao, Lu, Passier, Robert

“…Cardiotoxicity remains a major cause of drug withdrawal, partially due to lacking predictability of animal models. Additionally, risk of cardiotoxicity…”
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Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration by Nollet, Edgar E, Duursma, Inez, Rozenbaum, Anastasiya, Eggelbusch, Moritz, Wüst, Rob C I, Schoonvelde, Stephan A C, Michels, Michelle, Jansen, Mark, van der Wel, Nicole N, Bedi, Kenneth C, Margulies, Kenneth B, Nirschl, Jeff, Kuster, Diederik W D, van der Velden, Jolanda

“…Abstract Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an…”
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SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca2 by Fertig, Bracy, Ling, Jiayue, Nollet, Edgar E., Dobi, Sara, Busiau, Tara, Ishikawa, Kiyotake, Yamada, Kelly, Lee, Ahyoung, Kho, Changwon, Wills, Lauren, Tibbo, Amy J., Scott, Mark, Grant, Kirsten, Campbell, Kenneth S., Birks, Emma J., MacQuaide, Niall, Hajjar, Roger, Smith, Godfrey L., Velden, Jolanda, Baillie, George S.

“…Post‐translational modification of the myofilament protein troponin I by phosphorylation is known to trigger functional changes that support enhanced…”
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SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca 2 by Fertig, Bracy, Ling, Jiayue, Nollet, Edgar E, Dobi, Sara, Busiau, Tara, Ishikawa, Kiyotake, Yamada, Kelly, Lee, Ahyoung, Kho, Changwon, Wills, Lauren, Tibbo, Amy J, Scott, Mark, Grant, Kirsten, Campbell, Kenneth S, Birks, Emma J, MacQuaide, Niall, Hajjar, Roger, Smith, Godfrey L, van der Velden, Jolanda, Baillie, George S

“…Post translational modification of the myofilament protein troponin I by phosphorylation is known to trigger functional changes that support enhanced…”
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The Cardioprotective Effects of Semaglutide Exceed Those of Dietary Weight Loss in Mice With HFpEF by Withaar, Coenraad, Meems, Laura M G, Nollet, Edgar E, Schouten, E Marloes, Schroeder, Marie A, Knudsen, Lotte B, Niss, Kristoffer, Madsen, Christian T, Hoegl, Annabelle, Mazzoni, Gianluca, van der Velden, Jolanda, Lam, Carolyn S P, Silljé, Herman H W, de Boer, Rudolf A

“…Obesity-related heart failure with preserved ejection fraction (HFpEF) has become a well-recognized HFpEF subphenotype. Targeting the unfavorable…”
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Integrating Clinical Phenotype With Multiomics Analyses of Human Cardiac Tissue Unveils Divergent Metabolic Remodeling in Genotype-Positive and Genotype-Negative Patients With Hypertrophic Cardiomyopathy by Nollet, Edgar E, Schuldt, Maike, Sequeira, Vasco, Binek, Aleksandra, Pham, Thang V, Schoonvelde, Stephan A C, Jansen, Mark, Schomakers, Bauke V, van Weeghel, Michel, Vaz, Fred M, Houtkooper, Riekelt H, Van Eyk, Jennifer E, Jimenez, Connie R, Michels, Michelle, Bedi, Jr, Kenneth C, Margulies, Kenneth B, Dos Remedios, Cristobal G, Kuster, Diederik W D, van der Velden, Jolanda

“…Hypertrophic cardiomyopathy (HCM) is caused by sarcomere gene mutations (genotype-positive HCM) in ≈50% of patients and occurs in the absence of mutations…”
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Western diet triggers cardiac dysfunction in heterozygous Mybpc3-targeted knock-in mice: A two-hit model of hypertrophic cardiomyopathy by Nollet, Edgar E., Algül, Sila, Goebel, Max, Schlossarek, Saskia, van der Wel, Nicole N., Jans, Judith J.M., van de Wiel, Mark A., Knol, Jaco C., Pham, Thang V., Piersma, Sander R., de Goeij-de Haas, Richard, Hermans, Jill, van Klinken, Jan Bert, van Weeghel, Michel, Houtkooper, Riekelt H., Carrier, Lucie, Jimenez, Connie R., Kuster, Diederik W.D., van der Velden, Jolanda

“…Phenotypic expression of hypertrophic cardiomyopathy (HCM) and disease course are associated with unfavorable metabolic health. We investigated if Western diet…”
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