Search Results - "Noland, Cameron L."

Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis by Wilson, Ross C., Tambe, Akshay, Kidwell, Mary Anne, Noland, Cameron L., Schneider, Catherine P., Doudna, Jennifer A.

“…RNA-mediated gene silencing in human cells requires the accurate generation of ∼22 nt microRNAs (miRNAs) from double-stranded RNA substrates by the…”
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siRNA Repositioning for Guide Strand Selection by Human Dicer Complexes by Noland, Cameron L., Ma, Enbo, Doudna, Jennifer A.

“…The human ribonuclease Dicer and its double-stranded RNA (dsRNA)-binding protein (dsRBP) partners TRBP and PACT play important roles in the biogenesis of…”
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Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling by Noland, Cameron L., Gierke, Sarah, Schnier, Paul D., Murray, Jeremy, Sandoval, Wendy N., Sagolla, Meredith, Dey, Anwesha, Hannoush, Rami N., Fairbrother, Wayne J., Cunningham, Christian N.

“…The Hippo signaling pathway is responsible for regulating the function of TEAD family transcription factors in metazoans. TEADs, with their co-activators…”
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Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing by Lee, Ho Young, Zhou, Kaihong, Smith, Alison Marie, Noland, Cameron L, Doudna, Jennifer A

“…During RNA interference and related gene regulatory pathways, the endonuclease Dicer cleaves precursor RNA molecules to produce microRNAs (miRNAs) and short…”
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Multiple sensors ensure guide strand selection in human RNAi pathways by Noland, Cameron L, Doudna, Jennifer A

“…Small RNAs guide RNA-induced silencing complexes (RISCs) to bind to cognate mRNA transcripts and trigger silencing of protein expression during RNA…”
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Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling by Holden, Jeffrey K., Crawford, James J., Noland, Cameron L., Schmidt, Stephen, Zbieg, Jason R., Lacap, Jennifer A., Zang, Richard, Miller, Gregory M., Zhang, Yue, Beroza, Paul, Reja, Rohit, Lee, Wendy, Tom, Jeffrey Y.K., Fong, Rina, Steffek, Micah, Clausen, Saundra, Hagenbeek, Thjis J., Hu, Taishan, Zhou, Zheng, Shen, Hong C., Cunningham, Christian N.

“…The transcriptional enhanced associate domain (TEAD) family of transcription factors serves as the receptors for the downstream effectors of the Hippo pathway,…”
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Structure of the essential inner membrane lipopolysaccharide–PbgA complex by Clairfeuille, Thomas, Buchholz, Kerry R., Li, Qingling, Verschueren, Erik, Liu, Peter, Sangaraju, Dewakar, Park, Summer, Noland, Cameron L., Storek, Kelly M., Nickerson, Nicholas N., Martin, Lynn, Dela Vega, Trisha, Miu, Anh, Reeder, Janina, Ruiz-Gonzalez, Maria, Swem, Danielle, Han, Guanghui, DePonte, Daniel P., Hunter, Mark S., Gati, Cornelius, Shahidi-Latham, Sheerin, Xu, Min, Skelton, Nicholas, Sellers, Benjamin D., Skippington, Elizabeth, Sandoval, Wendy, Hanan, Emily J., Payandeh, Jian, Rutherford, Steven T.

“…Lipopolysaccharide (LPS) resides in the outer membrane of Gram-negative bacteria where it is responsible for barrier function 1 , 2 . LPS can cause death as a…”
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Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel by Noland, Cameron L., Chua, Han Chow, Kschonsak, Marc, Heusser, Stephanie Andrea, Braun, Nina, Chang, Timothy, Tam, Christine, Tang, Jia, Arthur, Christopher P., Ciferri, Claudio, Pless, Stephan Alexander, Payandeh, Jian

“…Unlike classical voltage-gated sodium (Na V ) channels, Na X has been characterized as a voltage-insensitive, tetrodotoxin-resistant, sodium (Na + )-activated…”
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Reconstitution reveals two paths of force transmission through the kinetochore by Hamilton, Grace E, Helgeson, Luke A, Noland, Cameron L, Asbury, Charles L, Dimitrova, Yoana N, Davis, Trisha N

“…Partitioning duplicated chromosomes equally between daughter cells is a microtubule-mediated process essential to eukaryotic life. A multi-protein machine, the…”
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Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase by Pantua, Homer, Skippington, Elizabeth, Braun, Marie-Gabrielle, Noland, Cameron L., Diao, Jingyu, Peng, Yutian, Gloor, Susan L., Yan, Donghong, Kang, Jing, Katakam, Anand Kumar, Reeder, Janina, Castanedo, Georgette M., Garland, Keira, Komuves, Laszlo, Sagolla, Meredith, Austin, Cary D., Murray, Jeremy, Xu, Yiming, Modrusan, Zora, Xu, Min, Hanan, Emily J., Kapadia, Sharookh B.

“…Despite increasing evidence suggesting that antibiotic heteroresistance can lead to treatment failure, the significance of this phenomena in the clinic is not…”
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Structural architecture of the human NALCN channelosome by Kschonsak, Marc, Chua, Han Chow, Weidling, Claudia, Chakouri, Nourdine, Noland, Cameron L., Schott, Katharina, Chang, Timothy, Tam, Christine, Patel, Nidhi, Arthur, Christopher P., Leitner, Alexander, Ben-Johny, Manu, Ciferri, Claudio, Pless, Stephan Alexander, Payandeh, Jian

“…Depolarizing sodium (Na + ) leak currents carried by the NALCN channel regulate the resting membrane potential of many neurons to modulate respiration,…”
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Structure of the human sodium leak channel NALCN by Kschonsak, Marc, Chua, Han Chow, Noland, Cameron L., Weidling, Claudia, Clairfeuille, Thomas, Bahlke, Oskar Ørts, Ameen, Aishat Oluwanifemi, Li, Zhong Rong, Arthur, Christopher P., Ciferri, Claudio, Pless, Stephan Alexander, Payandeh, Jian

“…Persistently depolarizing sodium (Na + ) leak currents enhance electrical excitability 1 , 2 . The ion channel responsible for the major background Na +…”
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Impact of Gene Copy Number Variation on Anesthesia in Drosophila melanogaster by ALONE, Debasmita P, RODRIGUEZ, Jason C, NOLAND, Cameron L, NASH, Howard A

“…Chromosomal deletions and duplications, which result in halving or doubling of copy number in a block of genes, are an important source of variation between…”
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Substrate-specific structural rearrangements of human Dicer by Taylor, David W, Ma, Enbo, Shigematsu, Hideki, Cianfrocco, Michael A, Noland, Cameron L, Nagayama, Kuniaki, Nogales, Eva, Doudna, Jennifer A, Wang, Hong-Wei

“…Human Dicer can process long double-stranded RNA and hairpin precursor RNA to yield short interfering RNAs or microRNAs, respectively. EM and single-particle…”
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Structural insights into lipoprotein N-acylation by Escherichia coli apolipoprotein N-acyltransferase by Noland, Cameron L., Kattke, Michele D., Diao, Jingyu, Gloor, Susan L., Pantua, Homer, Reichelt, Mike, Katakam, Anand K., Yan, Donghong, Kang, Jing, Zilberleyb, Inna, Xu, Min, Kapadia, Sharookh B., Murray, Jeremy M.

“…Gram-negative bacteria express a diverse array of lipoproteins that are essential for various aspects of cell growth and virulence, including nutrient uptake,…”
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Inhibition of Escherichia coli lipoprotein diacylglyceryl transferase is insensitive to resistance caused by deletion of Braun's lipoprotein by Diao, Jingyu, Komura, Rie, Sano, Tatsuya, Pantua, Homer, Storek, Kelly M, Inaba, Hiroko, Ogawa, Haruhiko, Noland, Cameron L, Peng, Yutian, Gloor, Susan L, Yan, Donghong, Kang, Jing, Katakam, Anand Kumar, Volny, Michael, Liu, Peter, Nickerson, Nicholas N, Sandoval, Wendy, Austin, Cary D, Murray, Jeremy, Rutherford, Steven T, Reichelt, Mike, Xu, Yiming, Xu, Min, Yanagida, Hayato, Nishikawa, Junichi, Reid, Patrick C, Cunningham, Christian N, Kapadia, Sharookh B

“…Lipoprotein diacylglyceryl transferase (Lgt) catalyzes the first step in the biogenesis of Gram-negative bacterial lipoproteins which play crucial roles in…”
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Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma by Wang, Xiaojing, Blackaby, Wesley, Allen, Vivienne, Chan, Grace Ka Yan, Chang, Jae H, Chiang, Po-Chang, Diène, Coura, Drummond, Jason, Do, Steven, Fan, Eric, Harstad, Eric B, Hodges, Alastair, Hu, Huiyong, Jia, Wei, Kofie, William, Kolesnikov, Aleksandr, Lyssikatos, Joseph P, Ly, Justin, Matteucci, Mizio, Moffat, John G, Munugalavadla, Veerendra, Murray, Jeremy, Nash, David, Noland, Cameron L, Del Rosario, Geoff, Ross, Leanne, Rouse, Craig, Sharpe, Andrew, Slaga, Dionysos, Sun, Minghua, Tsui, Vickie, Wallweber, Heidi, Yu, Shang-Fan, Ebens, Allen J

“…Pim kinases have been targets of interest for a number of therapeutic areas. Evidence of durable single-agent efficacy in human clinical trials validated Pim…”
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Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants by Hollingsworth, Scott A., Noland, Cameron L., Vroom, Karin, Saha, Anasuya, Sam, Miranda, Gao, Qinshan, Zhou, Haihong, Grandy, David U., Singh, Sujata, Wen, Zhiyun, Warren, Christopher, Ma, Xiaohong Shirley, Malashock, Daniel, Galli, Jennifer, Go, Gwenny, Eddins, Michael, Mayhood, Todd, Sathiyamoorthy, Karthik, Fridman, Arthur, Raoufi, Fahimeh, Gomez-Llorente, Yacob, Patridge, Andrea, Tang, Yinyan, Chen, Shi-Juan, Bailly, Marc, Ji, Chengjie, Kingsley, Laura J., Cheng, Alan C., Geierstanger, Bernhard H., Gorman, Daniel M., Zhang, Lan, Pande, Kalyan

“…Coronaviruses have been the causative agent of three epidemics and pandemics in the past two decades, including the ongoing COVID-19 pandemic. A…”
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An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance by Hagenbeek, Thijs J, Zbieg, Jason R, Hafner, Marc, Mroue, Rana, Lacap, Jennifer A, Sodir, Nicole M, Noland, Cameron L, Afghani, Shervin, Kishore, Ayush, Bhat, Kamakoti P, Yao, Xiaosai, Schmidt, Stephen, Clausen, Saundra, Steffek, Micah, Lee, Wendy, Beroza, Paul, Martin, Scott, Lin, Eva, Fong, Rina, Di Lello, Paola, Kubala, Marta H, Yang, Michelle N-Y, Lau, Jeffrey T, Chan, Emily, Arrazate, Alfonso, An, Le, Levy, Elizabeth, Lorenzo, Maria N, Lee, Ho-June, Pham, Trang H, Modrusan, Zora, Zang, Richard, Chen, Yi-Chen, Kabza, Michal, Ahmed, Musaddeque, Li, Jason, Chang, Matthew T, Maddalo, Danilo, Evangelista, Marie, Ye, Xin, Crawford, James J, Dey, Anwesha

“…The Hippo pathway is a key growth control pathway that is conserved across species. The downstream effectors of the Hippo pathway, YAP (Yes-associated protein)…”
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Structure-guided unlocking of Na X reveals a non-selective tetrodotoxin-sensitive cation channel by Noland, Cameron L, Chua, Han Chow, Kschonsak, Marc, Heusser, Stephanie Andrea, Braun, Nina, Chang, Timothy, Tam, Christine, Tang, Jia, Arthur, Christopher P, Ciferri, Claudio, Pless, Stephan Alexander, Payandeh, Jian

“…Unlike classical voltage-gated sodium (Na ) channels, Na has been characterized as a voltage-insensitive, tetrodotoxin-resistant, sodium (Na )-activated…”
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