Search Results - "Noker, P. E."

Pharmacokinetics of Perfluorooctanoate in Cynomolgus Monkeys by Butenhoff, J. L., Kennedy, G. L., Hinderliter, P. M., Lieder, P. H., Jung, R., Hansen, K. J., Gorman, G. S., Noker, P. E., Thomford, P. J.

“…The pharmacokinetics of perfluorooctanoate (PFOA) in cynomolgus monkeys were studied in a six-month oral capsule dosing study of ammonium perfluorooctanoate…”
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Toxicity of methylsulfonylmethane in rats by Horváth, K, Noker, P.E, Somfai-Relle, S, Glávits, R, Financsek, I, Schauss, A.G

“…Methylsulfonylmethane (MSM) is a popular dietary supplement used in a variety of conditions including pain, inflammation, allergies, arthritis, parasitic…”
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Purine nucleoside phosphorylase inhibitors: biochemical and pharmacological studies with 9-benzyl-9-deazaguanine and related compounds by Bennett, Jr, L L, Allan, P W, Noker, P E, Rose, L M, Niwas, S, Montgomery, J A, Erion, M D

“…Certain derivatives of 9-deazaguanine that contain arylmethyl, heteroarylmethyl or cycloalkylmethyl groups at the 9-position are potent inhibitors of purine…”
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Antimitotic agents: structure-activity studies with some pyridine derivatives by Temple, Carroll, Rener, Gregory A, Waud, William R, Noker, Patricia E

“…Antitumor activity in mice was observed for the oxime of the previously reported ethyl [6-amino-4-[(1-methyl-2-phenyl-2-oxoethyl)amino]-5-nitropyridin -2-yl]…”
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Role of Hepatic Tetrahydrofolate in the Species Difference in Methanol Toxicity by Black, Kurt A., Eells, Janis T., Noker, Patricia E., Hawtrey, Catherine A., Tephly, Thomas R.

“…The susceptibility of various species to methanol toxicity is inversely related to the rate of tetrahydrofolate (H4folate)-dependent formate oxidation to…”
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Diversity of penetration of anti-cancer agents into solid tumours by Simpson-Herren, L, Noker, P E

“…Failure of anti-cancer agents to reach all clonogenic cells at cytotoxic concentrations is recognized as an important form of resistance in solid tumours…”
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Variability of tumor response to chemotherapy. II: Contribution of tumor heterogeneity by SIMPSON-HERREN, L, NOKER, P. E, WAGONER, S. D

“…The role of tumor-to-tumor variability in response to chemotherapy was investigated in mice bearing mammary adenocarcinoma 16/C treated with melphalan…”
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Distribution of adriamycin in mice bearing mammary adenocarcinoma 16/C by Simpson-Herren, L, Noker, P E

“…The response of solid mammary adenocarcinoma 16/C to treatment with Adriamycin is highly variable and ranges from growth under treatment to complete…”
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Methanol poisoning and formate oxidation in nitrous oxide-treated rats by Eells, J T, Makar, A B, Noker, P E, Tephly, T R

“…Formic acid does not accumulate in the rat after the administration of methanol as it does in methanol-poisoned humans and monkeys. In addition, rats do not…”
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Variability of tumor response to chemotherapy. I: Contribution of host heterogeneity by SIMPSON-HERREN, L, NOKER, P. E, WAGONER, S. D

“…Host factors that might be associated with the variable response of tumors to effective chemotherapy were studied in B6C3F1 mice bearing transplanted mammary…”
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Dose-related doxorubicin effect in an orthotopic secondary lung cancer screen by Cowen, M E, Howard, R B, Noker, P E, Zeligman, B E, Mulvin, D W, Marcell, T, Johnston, M R

“…Lung cancer is the leading cause of cancer-related death of both sexes in the United States and promises to be a major problem in the world community for…”
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Secondary screening system for preclinical testing of human lung cancer therapies by Mulvin, D W, Howard, R B, Mitchell, D H, Noker, P E, Kruse, C A, Chu, H D, Bunn, P A, Johnston, M R

“…The National Cancer Institute has instituted a primary screening system for testing new agents against cultured cancer cell lines. The purpose of this study…”
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A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans by Olsen, Geary W, Chang, Shu-Ching, Noker, Patricia E, Gorman, Gregory S, Ehresman, David J, Lieder, Paul H, Butenhoff, John L

“…Abstract Materials derived from perfluorobutanesulfonyl fluoride (PBSF, C4 F9 SO2 F) have been introduced as replacements for eight-carbon homolog products…”
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Pharmacokinetic and metabolism studies of two novel 1-deaza-7,8-dihydropteridines in mice by Noker, P E, Hill, D L, Kalin, J R, Temple, Jr, C G, Montgomery, J A

“…The disposition of two 1-deaza-7,8-dihydropteridines, NSC 269416 and NSC 350386, was studied in mice dosed iv. After dosing with 25 mg/kg of NSC 269416, serum…”
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Disposition of sucrose octa-isobutyrate in rats, dogs and monkeys by Noker, P E, Kalin, J R, McCarthy, D J, el Dareer, S M, Chappel, C I

“…The disposition of 200 mg/kg of 14C-labelled sucrose octa-isobutyrate (14C-SOIB), a component of sucrose acetate isobutyrate (SAIB), a beverage emulsion…”
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Methanol toxicity: treatment with folic acid and 5-formyl tetrahydrofolic acid by Noker, P E, Eells, J T, Tephly, T R

“…After methanol administration to monkeys, an accumulation of formate in blood occurs coincident with the development of metabolic acidosis and a depletion of…”
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Distribution of nitroimidazoles and L-phenylalanine mustard in mammary adenocarcinoma 16/C tumors by Noker, P E, Simpson-Herren, L, Wagoner, S D

“…Using the triphenylmethane dye, lissamine green, as an indicator of blood perfusion, we have demonstrated that L-phenylalanine mustard (L-PAM) is…”
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Effects of the initial chemotherapy on subsequent therapy by Simpson-Herren, L, Noker, P E

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Distribution of clomesone in mice by Noker, P E, Hill, D L

“…The distribution of the novel alkylating agent clomesone [2-chloroethyl (methylsulfonyl)-methane sulfonate] has been studied in mice after iv administration of…”
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Metabolism of 14C-labelled sucrose esters of stearic acid in rats by Noker, P.E., Lin, T.-H., Hill, D.L., Shigeoka, T.

“…Rats were dosed by oral gavage (250 mg/kg) with compounds containing sucrose esterified in four, six or eight positions with stearic acid. For each compound,…”
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