Search Results - "Nojima, Masatomo"

Stage specific activity of synthetic antimalarial endoperoxides, N-89 and N-251, against Plasmodium falciparum by Morita, Masayuki, Koyama, Takahiko, Sanai, Hitomi, Sato, Akira, Hiramoto, Akiko, Masuyama, Araki, Nojima, Masatomo, Wataya, Yusuke, Kim, Hye-Sook

“…Abstract We have reported that two endoperoxides, N-89 and N-251, synthesized in 2001, possess potent antimalarial activities. Aiming at their eventual use for…”
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Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol by Sato, Akira, Hiramoto, Akiko, Morita, Masayuki, Matsumoto, Masahiro, Komich, Yuka, Nakase, Yukari, Tanigawa, Natsuki, Hiraoka, Osamu, Hiramoto, Kazuyuki, Hayatsu, Hikoya, Higaki, Kazutaka, Kawai, Satoru, Masuyama, Araki, Nojima, Masatomo, Wataya, Yusuke, Kim, Hye-Sook

“…Abstract Plasmodium falciparum , the major causative parasite for the disease, has acquired resistance to most of the antimalarial drugs used today, presenting…”
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Antimalarial activity of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) and its carboxylic acid derivatives by Sato, Akira, Kawai, Satoru, Hiramoto, Akiko, Morita, Masayuki, Tanigawa, Natsuki, Nakase, Yukari, Komichi, Yuka, Matsumoto, Masahiro, Hiraoka, Osamu, Hiramoto, Kazuyuki, Tokuhara, Hidekazu, Masuyama, Araki, Nojima, Masatomo, Higaki, Kazutaka, Hayatsu, Hikoya, Wataya, Yusuke, Kim, Hye-Sook

“…Abstract Malaria is one of the world's deadliest diseases and is becoming an increasingly serious problem as malaria parasites develop resistance to most of…”
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Effects of Spiroconjugation on the Calculated Singlet−Triplet Energy Gap in 2,2-Dialkoxycyclopentane-1,3-diyls and on the Experimental Electronic Absorption Spectra of Singlet 1,3-Diphenyl Derivatives. Assignment of the Lowest-Energy Electronic Transition of Singlet Cyclopentane-1,3-diyls by Abe, Manabu, Adam, Waldemar, Borden, Weston Thatcher, Hattori, Masanori, Hrovat, David A, Nojima, Masatomo, Nozaki, Koichi, Wirz, Jakob

“…The effect of a 2,2-ethylene-ketal functionality on the singlet−triplet energy gap (ΔE ST) and on the first electronic transition in singlet…”
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Synthesis and Antimalarial Activity of Novel Medium-Sized 1,2,4,5-Tetraoxacycloalkanes by Kim, Hye-Sook, Nagai, Yukiko, Ono, Kanako, Begum, Khurshida, Wataya, Yusuke, Hamada, Yoshiaki, Tsuchiya, Kaoru, Masuyama, Araki, Nojima, Masatomo, McCullough, Kevin J

“…CsOH- or Ag2O-mediated cycloalkylation of (alkylidene)bisperoxides 3 and 1,n-dihaloalkanes (n = 3−8) provided the corresponding medium-sized…”
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Schistosomicidal and antifecundity effects of oral treatment of synthetic endoperoxide N-89 by Taniguchi, Toshie, Kumagai, Takashi, Shimogawara, Rieko, Ichinose, Shizuko, Hiramoto, Akiko, Sato, Akira, Morita, Masayuki, Nojima, Masatomo, Kim, Hye-Sook, Wataya, Yusuke, Ohta, Nobuo

“…Abstract 1,2,6,7-Tetraoxaspiro[7.11]nonadecane (N-89) is a chemically synthesized compound with good efficacy against malaria parasites. We observed strong…”
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DFT Prediction of Ground-State Spin Multiplicity of Cyclobutane-1,3-diyls:  Notable Effects of Two Sets of Through-Bond Interactions by Abe, Manabu, Ishihara, Chizuko, Nojima, Masatomo

“…DFT calculations (UB3LYP/6-31+G**) have been performed to predict the substituent effect on the ground-state spin-multiplicity and the singlet−triplet energy…”
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Synthesis and Antimalarial Activity of Cyclic Peroxides, 1,2,4,5,7-Pentoxocanes and 1,2,4,5-Tetroxanes by Kim, Hye-Sook, Shibata, Yasuharu, Wataya, Yusuke, Tsuchiya, Kaoru, Masuyama, Araki, Nojima, Masatomo

“…A variety of 1,2,4,5,7-pentoxocane and 1,2,4,5-tetroxane derivatives were prepared as potential peroxide antimalarial agents. In both series of cyclic…”
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2-Silyl Group Effect on the Reactivity of Cyclopentane-1,3-diyls. Intramolecular Ring-Closure versus Silyl Migration by Abe, Manabu, Kawanami, Satoshi, Ishihara, Chizuko, Nojima, Masatomo

“…Generation of singlet and triplet 2-silylcyclopentane-1,3-diyls and their reactivity have been investigated in the thermal and photochemical denitrogenation of…”
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On the Electronic Character of Localized Singlet 2,2-Dimethoxycyclopentane-1,3-diyl Diradicals:  Substituent Effects on the Lifetime by Abe, Manabu, Adam, Waldemar, Hara, Michihiro, Hattori, Masanori, Majima, Tetsuro, Nojima, Masatomo, Tachibana, Kei, Tojo, Sachiko

“…Photodenitrogenation of the diazenes 4 affords exclusively the housanes 5 through intramolecular cyclization of the spectrally detected and characterized…”
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Paternò−Büchi Photocyclization of 2-Siloxyfurans and Carbonyl Compounds. Notable Substituent and Carbonyl (Aldehyde vs Ketone and Singlet- vs Triplet-Excited State) Effects on the Regioselectivity (Double-Bond Selection) in the Formation of Bicyclic exo-Oxetanes by ABE, Manabu, TORII, Etsuko, NOJIMA, Masatomo

“…Paterno-Buchi coupling, photochemical [2 + 2] cycloaddition, of carbonyl compounds 2a-f with 2-siloxyfurans 1a-d has been investigated in detail. The…”
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Antimalarial Activity of Novel 1,2,5,6-Tetraoxacycloalkanes and 1,2,5-Trioxacycloalkanes by Kim, Hye-Sook, Begum, Khurshida, Ogura, Naoki, Wataya, Yusuke, Nonami, Yuji, Ito, Toyonari, Masuyama, Araki, Nojima, Masatomo, McCullough, Kevin J

“…Photooxygenation of 2-phenylnorbornene 1 in the presence of 30% aqueous hydrogen peroxide afforded 1,2-bishydroperoxide 3, which could be cycloalkylated on…”
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Proteome analysis of new antimalarial endoperoxide against Plasmodium falciparum by Aly, Nagwa S. M, Hiramoto, Akiko, Sanai, Hitomi, Hiraoka, Osamu, Hiramoto, Kazuyuki, Kataoka, Hiroyuki, Wu, Jin-Ming, Masuyama, Araki, Nojima, Masatomo, Kawai, Satoru, Kim, Hye-Sook, Wataya, Yusuke

“…N-89, a new antimalarial endoperoxide, was selected as a promising antimalarial compound showing high activity and selectivity. To study the mechanism of N-89…”
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Determination of stereochemistry and separation of diastereomeric derivatives of trans-2-pyridylcyclohexanols by extraction by Matsugi, Masato, Nojima, Masatomo, Hagimoto, Yuri, Kita, Yasuyuki

“…The example of the determination of the stereochemistry and separation of diastereomeric derivatives of trans-2-pyridylcyclohexanols by extraction is shown…”
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New pH-Sensitive Vesicles. Release Control of Trapped Materials from the Inner Aqueous Phase of Vesicles Made from Triple-Chain Amphiphiles Bearing Two Carboxylate Groups by Sumida, Yasushi, Masuyama, Araki, Takasu, Mayuko, Kida, Toshiyuki, Nakatsuji, Yohji, Ikeda, Isao, Nojima, Masatomo

“…The pH-induced release of trapped materials from the inner aqueous phase of vesicles made from the synthetic triple-chain amphiphile 1 bearing two carboxyl…”
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The synthesis and crystal structure analysis of novel macrocyclic peroxides by McCullough, Kevin J, Ito, Toyonari, Tokuyasu, Takahiro, Masuyama, Araki, Nojima, Masatomo

“…Bis( syn-collidine)iodine(I) hexafluorophosphate-mediated cyclization of unsaturated hydroperoxides afforded the corresponding 11- to 16-membered macrocyclic…”
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Synthesis, crystal structure and antimalarial activity of novel 1,2,5,6-tetraoxacycloalkanes from 2,3-dihydroperoxy-2-phenylnorbornane by McCullough, Kevin J., Nonami, Yuji, Masuyama, Araki, Nojima, Masatomo, Kim, Hye-Sook, Wataya, Yusuke

“…Photooxygenation of 2-phenylnorbornene 1 in the presence of 30% aqueous hydrogen peroxide in acetonitrile afforded the labile 1,2-bis-hydroperoxide 3 which…”
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Stereochemical Deuterium Labeling as Mechanistic Probe for Differentiating the Singlet- and Triplet-Diradical Spin States in the Rearrangement of the 2-Spiroepoxy-1,3-cyclopentanediyl to Oxetanes by Abe, Manabu, Adam, Waldemar, Ino, Yasunori, Nojima, Masatomo

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Synthesis of Hydroxy(or Hydroperoxy)-Substituted 1,2,4-Trioxacycloalkanes by the Ozonolysis of Unsaturated Hydroperoxy Acetals by Ushigoe, Yoshihiro, Torao, Yuko, Masuyama, Araki, Nojima, Masatomo

“…Ozonolyses of unsaturated hydroperoxy acetals 4a−k gave in each case the mixtures of products containing the corresponding trioxanes 8a−f and 12e,f,…”
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Behavior of Self-Organized Molecular Assemblies Composed of Phosphatidylcholines and Synthetic Triple-Chain Amphiphiles in Water by Sumida, Yasushi, Masuyama, Araki, Takasu, Mayuko, Kida, Toshiyuki, Nakatsuji, Yohji, Ikeda, Isao, Nojima, Masatomo

“…The enhancing effect of synthetic triple-chain amphiphiles on the stability of a vesicle made from phosphatidylcholine was investigated in terms of the leakage…”
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