Search Results - "Nojima, Koji"

Analysis of hepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet by Nojima, Koji, Sugimoto, Ken, Ueda, Hironori, Babaya, Naru, Ikegami, Hiroshi, Rakugi, Hiromi

“…Both genetic factors and diabetogenic environmental factors, such as a high-sucrose diet (HSD), are involved in the development of type 2 diabetes. In this…”
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Prevention and Treatment of Obesity, Insulin Resistance, and Diabetes by Bile Acid–Binding Resin by KOBAYASHI, Misato, IKEGAMI, Hiroshi, SHIBATA, Masao, OGIHARA, Toshio, FUJISAWA, Tomomi, NOJIMA, Koji, KAWABATA, Yumiko, NOSO, Shinsuke, BABAYA, Naru, ITOI-BABAYA, Michiko, YAMAJI, Kaori, HIROMINE, Yoshihisa

“…Prevention and Treatment of Obesity, Insulin Resistance, and Diabetes by Bile Acid–Binding Resin Misato Kobayashi 1 , Hiroshi Ikegami 1 2 , Tomomi Fujisawa 1 ,…”
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Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model by Shindo, Nobuyasu, Fujisawa, Tomomi, Sugimoto, Ken, Nojima, Koji, Oze-Fukai, Aya, Yoshikawa, Yuki, Wang, Xiang, Yasuda, Osamu, Ikegami, Hiroshi, Rakugi, Hiromi

“…Background & Aims Nonalcoholic fatty liver disease (NAFLD) is currently recognized as a global health issue and encompasses a wide spectrum of entities,…”
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Analysis of the expression of candidate genes for type 1 diabetes susceptibility in T cells by Hisanaga-Oishi, Yuko, Nishiwaki-Ueda, Yumiko, Nojima, Koji, Ueda, Hironori

“…Type 1 diabetes is characterized by T-cell-mediated autoimmune destruction of pancreatic β-cells. Currently, approximately 50 type 1 diabetes susceptibility…”
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Dose Effect and Mode of Inheritance of Diabetogenic Gene on Mouse Chromosome 11 by Babaya, Naru, Ueda, Hironori, Noso, Shinsuke, Hiromine, Yoshihisa, Nojima, Koji, Itoi-Babaya, Michiko, Kobayashi, Misato, Fujisawa, Tomomi, Ikegami, Hiroshi

“…The quantitative trait locus (QTL) mapping in segregating crosses of NSY (Nagoya-Shibata-Yasuda) mice, an animal model of type 2 diabetes, with nondiabetic…”
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A Novel Mouse Model for Type 2 Diabetes and Non-alcoholic Fatty Liver Disease: Spontaneous Amelioration of Diabetes by Augmented Beta Cell Mass by OZE-FUKAI, Aya, FUJISAWA, Tomomi, SUGIMOTO, Ken, NOJIMA, Koji, SHINDO, Nobuyasu, SHIMOYOSHI, Satomi, YOSHIKAWA, Yuki, SATO, Yoshifumi, SHIMOMURA, Iichirou, IKEGAMI, Hiroshi, RAKUGI, Hiromi

“…Given the potential for β-cells to increase their mass, glucose intolerance might be ameliorated by a compensatory increase in β-cell mass. However, it remains…”
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Analysis of the expression of candidate genes for type 1 diabetes susceptibility in T cells by Yuko Hisanaga-Oishi, Yumiko Nishiwaki-Ueda, Koji Nojima, Hironori Ueda

“…[Abstract] Type 1 diabetes is characterized by T-cell-mediated autoimmune destruction of pancreatic β-cells. Currently, approximately 50 type 1 diabetes…”
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Susceptibility to streptozotocin-induced diabetes is mapped to mouse chromosome 11 by Babaya, Naru, Ikegami, Hiroshi, Fujisawa, Tomomi, Nojima, Koji, Itoi-Babaya, Michiko, Inoue, Kaori, Ohno, Tamio, Shibata, Masao, Ogihara, Toshio

“…To study the contribution of β-cell vulnerability to susceptibility to diabetes, we studied β-cell vulnerability to a single high dose of streptozotocin (STZ)…”
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A Novel Mouse Model for Type 2 Diabetes and Non-alcoholic Fatty Liver Disease: Spontaneous Amelioration of Diabetes by Augmented Beta Cell Mass by AYA OZE-FUKAI, TOMOMI FUJISAWA, KEN SUGIMOTO, KOJI NOJIMA, NOBUYASU SHINDO, SATOMI SHIMOYOSHI, YUKI YOSHIKAWA, YOSHIFUMI SATO, IICHIROU SHIMOMURA, HIROSHI IKEGAMI, HIROMI RAKUGI

“…Abstract. Given the potential for β-cells to increase their mass, glucose intolerance might be ameliorated by a compensatory increase in β-cell mass. However,…”
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Common genetic basis between type 1 and type 2 diabetes mellitus indicated by interview-based assessment of family history by Fujisawa, Tomomi, Ikegami, Hiroshi, Kawaguchi, Yoshihiko, Nojima, Koji, Kawabata, Yumiko, Ono, Masaya, Nishino, Masanori, Noso, Shinsuke, Taniguchi, Hidenori, Horiki, Mayumi, Itoi-Babaya, Michiko, Babaya, Naru, Inoue, Kaori, Ogihara, Toshio

“…To investigate the intrafamilial clustering of type 1 and type 2 diabetes, an interview-based assessment of family history of diabetes was conducted…”
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Sequence Analysis of Candidate Genes for Common Susceptibility to Type 1 and Type 2 Diabetes in Mice by Yamada, K, Ikegami, H, Kawaguchi, Y, Fujisawa, T, Hotta, M, Ueda, H, Shintani, M, Nojima, K, Kawabata, Y, Ono, M, Nishino, M, Itoi, M, Babaya, N, Shibata, M, Makino, S, Ogihara, T

“…Although type 1 and type 2 diabetes are regarded as clinically distinct diseases, several lines of evidence have suggested common genetic factors between the…”
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Paternal-maternal effects on phenotypic characteristics in spontaneously diabetic Nagoya-Shibata-Yasuda mice by Ueda, Hironori, Ikegami, Hiroshi, Kawaguchi, Yoshihiko, Fujisawa, Tomomi, Nojima, Koji, Babaya, Naru, Yamada, Kazunori, Shibata, Masao, Yamato, Eiji, Ogihara, Toshio

“…The Nagoya-Shibata-Yasuda (NSY) mouse is an inbred strain with spontaneous development of type 2 (non-insulin-dependent) diabetes mellitus. The purpose of this…”
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Molecular Scanning of Interleukin-21 Gene and Genetic Susceptibility to Type 1 Diabetes by Asano, Katsuaki, Ikegami, Hiroshi, Fujisawa, Tomomi, Nishino, Masanori, Nojima, Koji, Kawabata, Yumiko, Noso, Shinsuke, Hiromine, Yoshihisa, Fukai, Aya, Ogihara, Toshio

“…Abstract A recent study in the nonobese diabetic (NOD) mouse demonstrated the involvement of interleukin (IL)–21 in the pathogenesis of type 1 diabetes. A…”
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Food hardness as environmental factor in development of type 2 diabetes by Nojima, Koji, Ikegami, Hiroshi, Fujisawa, Tomomi, Ueda, Hironori, Babaya, Naru, Itoi-Babaya, Michiko, Yamaji, Kaori, Shibata, Masao, Ogihara, Toshio

“…The effect of hardness of the diet as an environmental factor on the development of diabetes was investigated in a mouse model of type 2 diabetes. NSY and…”
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Trinucleotide repeats of programmed cell death-1 gene are associated with susceptibility to type 1 diabetes mellitus by Hiromine, Yoshihisa, Ikegami, Hiroshi, Fujisawa, Tomomi, Nojima, Koji, Kawabata, Yumiko, Noso, Shinsuke, Asano, Katsuaki, Fukai, Aya, Ogihara, Toshio

“…Abstract Multiple genes are involved in conferring susceptibility to autoimmune type 1 diabetes mellitus. The immunoreceptor programmed cell death-1 (PDCD-1),…”
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Present state of diabetes management in the elderly, Japan by Fujisawa, Tomomi, Ikegami, Hiroshi, Nojima, Koji, Kawabata, Yumiko, Noso, Shinsuke, Asano, Katsuaki, Hiromine, Yoshihisa, Fukai, Aya, Shindo, Nobuyasu, Ogihara, Toshio

“…Abstract A recent dramatic increase in elderly patients with diabetes mellitus has made the proper management of the disease in this population more important…”
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MHC-linked susceptibility to type 1 diabetes in the NOD mouse: further localization of Idd16 by subcongenic analysis by Fujisawa, Tomomi, Ikegami, Hiroshi, Noso, Shinsuke, Yamaji, Kaori, Nojima, Koji, Babaya, Naru, Itoi-Babaya, Michiko, Hiromine, Yoshihisa, Kobayashi, Misato, Makino, Susumu, Ogihara, Toshio

“…Although major histocompatibility complex (MHC)-linked susceptibility is the strongest component, recent studies demonstrated that MHC-linked susceptibility to…”
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MHC-Linked Susceptibility to Type 1 Diabetes in the NOD Mouse by FUJISAWA, TOMOMI, IKEGAMI, HIROSHI, NOSO, SHINSUKE, YAMAJI, KAORI, NOJIMA, KOJI, BABAYA, NARU, ITOI-BABAYA, MICHIKO, HIROMINE, YOSHIHISA, KOBAYASHI, MISATO, MAKINO, SUSUMU, OGIHARA, TOSHIO

“…:  Although major histocompatibility complex (MHC)‐linked susceptibility is the strongest component, recent studies demonstrated that MHC‐linked susceptibility…”
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Contribution of Class III MHC to Susceptibility to Type 1 Diabetes in the NOD Mouse by YAMAJI, KAORI, IKEGAMI, HIROSHI, FUJISAWA, TOMOMI, NOSO, SHINSUKE, NOJIMA, KOJI, BABAYA, NARU, ITOI-BABAYA, MICHIKO, KOBAYASHI, MISATO, HIROMINE, YOSHIHISA, MAKINO, SUSUMU, OGIHARA, TOSHIO

“…:  A recombinant major histocompatibility complex (MHC) with the same class III region as the NOD mouse, but different class II region from the NOD mouse was…”
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Association of I27L Polymorphism of Hepatocyte Nuclear Factor-1α Gene with High-Density Lipoprotein Cholesterol Level by Babaya, Naru, Ikegami, Hiroshi, Fujisawa, Tomomi, Nojima, Koji, Itoi-Babaya, Michiko, Inoue, Kaori, Nakura, Jun, Abe, Michiko, Yamamoto, Miyuki, Jin, Jin Ji, Wu, Zhihong, Miki, Tetsuro, Fukuda, Masakatsu, Ogihara, Toshio

“…The serum level of high-density lipoprotein cholesterol (HDL-c), which protects against the development of atherosclerosis, is under genetic control. However,…”
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