Search Results - "Nogusa, Hideo"

Practical and versatile oxidation of alcohol using novel Na2WO4-H2O2 system under neutral conditions by HIDA, Takemasa, NOGUSA, Hideo

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Distribution Characteristics of Carboxymethylpullulan-Peptide-Doxorubicin Conjugates in Tumor-Bearing Rats : Different Sequence of Peptide Spacers and Doxorubicin Contents by NOGUSA, Hideo, YAMAMOTO, Keiji, YANO, Toshiro, KAJIKI, Masahiro, HAMANA, Hiroshi, OKUNO, Satoshi

“…Plasma and tissue distribution of conjugates of carboxymethylpullulan (CMPul) and doxorubicin (DXR), either bound directly or through three types of…”
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Structure-activity relationships of carboxymethylpullulan-peptide-doxorubicin conjugates : Systematic modification of peptide spacers by NOGUSA, H, YANO, T, KASHIMA, N, YAMAMOTO, K, OKUNO, S, HAMANA, H

“…A series of carboxymethylpullulan (CMPul)-doxorubicin (DXR) conjugates bound by peptide spacers of different compositions and lengths were prepared and…”
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Improved in vivo Antitumor Efficacy and Reduced Systemic Toxicity of Carboxymethylpullulan‐peptide‐doxorubicin Conjugates by Nogusa, Hideo, Hamana, Hiroshi, Uchida, Naomi, Maekawa, Ryuji, Yoshioka, Takayuki

“…The antitumor efficacy of the conjugate of doxorubicin (DXR) and carboxymethylpullulan (CMPul) with Phe‐Gly spacer (CMPul‐FG‐DXR) was evaluated using murine…”
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Practical and versatile oxidation of alcohol using novel Na 2WO 4–H 2O 2 system under neutral conditions by Hida, Takemasa, Nogusa, Hideo

“…This paper presents a novel Na 2WO 4–H 2O 2 oxidation system. The oxidation of alcohol to ketone or aldehyde was carried out by using N, N-dimethylacetamide,…”
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Antitumor effects and toxicities of carboxymethylpullulan-peptide-doxorubicin conjugates by NOGUSA, H, YANO, T, KAJIKI, M, GONSHO, A, HAMANA, H, OKUNO, S

“…In vivo antitumor effects of the conjugates of doxorubicin (DXR) with carboxymethylpullulan (CMPul) through tetrapeptide spacers were compared with those of…”
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Risk Assessment and Safety Evaluation Study for Ozonolysis of β-Pinene: Raw Material of a Novel Prostaglandin D 2 Receptor Antagonist S-5751 by Hida, Takemasa, Kikuchi, Junko, Kakinuma, Makoto, Nogusa, Hideo

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Practical Application of Oxidation Using a Novel Na2WO4−H2O2 System under Neutral Conditions for Scale-Up Manufacturing of 12α-Hydroxy-3-oxooleanano-28,13-lactone: Key Intermediate of Endothelin A Receptor Antagonist S-0139 by Hida, Takemasa, Fukui, Yuuki, Kawata, Kyozo, Kabaki, Mikio, Masui, Toshiaki, Fumoto, Masataka, Nogusa, Hideo

“…Novel alcohol oxidation using a Na2WO4−H2O2 system was applied to manufacture 12α-hydroxy-3-oxooleanano-28,13-lactone which is a key intermediate of S-0139…”
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Absence of Lysosomal Cleavage in the Cytotoxicity Mechanism of an Immunoconjugate Composed of Anti-α-fetoprotein Monoclonal Antibody and Vindesine Analog by NAGATA, Shunji, MASUDA, Kazuyoshi, NOGUSA, Hideo, HIRANO, Koichiro, TAKAGISHI, Yasushi

“…The effect of lysosomal enzyme inhibition on the cytotoxic activity of an immunoconjugate composed of anti-α-fetoprotein monoclonal antibody and vindesine…”
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Practical Diastereoselective Synthesis and Scale-up Study of (+)-2-((1 R ,2 R ,3 R ,5 S )-2-Amino-6,6-dimethylbicyclo[3.1.1]hept-3-yl)ethanol: A Key Intermediate of the Novel Prostaglandin D 2 Receptor Antagonist S-5751 by Hida, Takemasa, Mitsumori, Susumu, Honma, Tsunetoshi, Hiramatsu, Yoshiharu, Hashizume, Hiroshi, Okada, Tetsuo, Kakinuma, Makoto, Kawata, Kyozo, Oda, Katsuo, Hasegawa, Aiko, Masui, Toshiaki, Nogusa, Hideo

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Practical Diastereoselective Synthesis and Scale-up Study of (+)-2-((1R,2R,3R,5S)-2-Amino-6,6-dimethylbicyclo[3.1.1]hept-3-yl)ethanol: A Key Intermediate of the Novel Prostaglandin D2 Receptor Antagonist S-5751 by Hida, Takemasa, Mitsumori, Susumu, Honma, Tsunetoshi, Hiramatsu, Yoshiharu, Hashizume, Hiroshi, Okada, Tetsuo, Kakinuma, Makoto, Kawata, Kyozo, Oda, Katsuo, Hasegawa, Aiko, Masui, Toshiaki, Nogusa, Hideo

“…A new synthetic process was developed for (+)-2-((1R,2R,3R,5S)-2-amino-6,6-dimethylbicyclo[3.1.1]hept-3-yl)ethanol, a key intermediate of S-5751…”
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New Application of Human Tumor Clonogenic Assay to in Vitro Evaluation of Tumor-Targeting Efficiency of Immunoconjugates by NAGATA, Shunji, MASUDA, Kazuyoshi, NOGUSA, Hideo, HIRANO, Koichiro, TAKAGISHI, Yasushi

“…This report proposes an efficient in vitro method for the evaluation of drug targeting with monoclonal antibody as a carrier to tumor cells. Monoclonal…”
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Practical Application of Oxidation Using a Novel Na 2 WO 4 −H 2 O 2 System under Neutral Conditions for Scale-Up Manufacturing of 12α-Hydroxy-3-oxooleanano-28,13-lactone: Key Intermediate of Endothelin A Receptor Antagonist S-0139 by Hida, Takemasa, Fukui, Yuuki, Kawata, Kyozo, Kabaki, Mikio, Masui, Toshiaki, Fumoto, Masataka, Nogusa, Hideo

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Development of One-Pot Synthesis of New Antiarthritic Drug Candidate S-2474 with High E-Selectivity by Oda, Katsuo, Hida, Takemasa, Sakata, Teruo, Nagai, Masahiko, Sugata, Yoshihide, Masui, Toshiaki, Nogusa, Hideo

“…A one-pot synthesis of S-2474 was developed to overcome the problems of a large number of steps, low stereoselectivity, low yield, a large amount of waste, and…”
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A novel electrogenerated base. Alkylation of methyl arylacetates at the .alpha.-methylene group by Shono, Tatsuya, Kashimura, Shigenori, Nogusa, Hideo

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Electroorganic chemistry. 59. Electroreductive synthesis of oximes from nitroolefins by Shono, Tatsuya, Hamaguchi, Hiroshi, Mikami, Hiroshi, Nogusa, Hideo, Kashimura, Shigenori

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Evaluation of carboxymethylpullulan as a novel carrier for targeting immune tissues by MASUDA, Kazuyoshi, SAKAGAMI, Masahiro, HORIE, Kazutoshi, NOGUSA, Hideo, HAMANA, Hiroshi, HIRANO, Koichiro

“…To demonstrate the potential of carboxymethylpullulan (CMPul) as a carrier for targeting immune tissues, and to find whether immune tissues could be set as the…”
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Risk Assessment and Safety Evaluation Study for Ozonolysis of β-Pinene: Raw Material of a Novel Prostaglandin D2 Receptor Antagonist S-5751 by Hida, Takemasa, Kikuchi, Junko, Kakinuma, Makoto, Nogusa, Hideo

“…Safety evaluation for ozonolysis of β-pinene was conducted using DSC, ARC, and RC1e. ARC measurement showed that the concentration of the ozonized mixture…”
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Distribution Characteristics of Carboxymethylpullulan-Peptide-Doxorubicin Conjugates in Tumor-Bearing Rats by NOGUSA, Hideo, YAMAMOTO, Keiji, YANO, Toshiro, KAJIKI, Masahiro, HAMANA, Hiroshi, OKUNO, Satoshi

“…Plasma and tissue distribution of conjugates of carboxymethylpullulan (CMPul) and doxorubicin (DXR), either bound directly or through three types of…”
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Synthesis of Carboxymethylpullulan-Peptide-Doxorubicin Conjugates and Their Properties by NOGUSA, Hideo, YANO, Toshiro, OKUNO, Satoshi, HAMANA, Hiroshi, INOUE, Kazuhiro

“…The amino group of doxorubicin (DXR) was found to be bound to the carboxyl group of carboxymethylpullulan (CMPul) either directly or through tetrapeptide…”
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