Search Results - "Nogueira, Veronique"

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy by NOGUEIRA, Veronique, HAY, Nissim

“…Reactive oxygen species (ROS) are important in regulating normal cellular processes, but deregulated ROS contribute to the development of various human…”
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Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin by DeWaal, Dannielle, Nogueira, Veronique, Terry, Alexander R., Patra, Krushna C., Jeon, Sang-Min, Guzman, Grace, Au, Jennifer, Long, Christopher P., Antoniewicz, Maciek R., Hay, Nissim

“…Hepatocellular carcinoma (HCC) cells are metabolically distinct from normal hepatocytes by expressing the high-affinity hexokinase (HK2) and suppressing…”
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A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis by Blaha, Catherine S., Ramakrishnan, Gopalakrishnan, Jeon, Sang-Min, Nogueira, Veronique, Rho, Hyunsoo, Kang, Soeun, Bhaskar, Prashanth, Terry, Alexander R., Aissa, Alexandre F., Frolov, Maxim V., Patra, Krushna C., Brooks Robey, R., Hay, Nissim

“…Hexokinase 2 (HK2), which catalyzes the first committed step in glucose metabolism, is induced in cancer cells. HK2’s role in tumorigenesis has been attributed…”
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Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation by Nogueira, Veronique, Patra, Krushna C, Hay, Nissim

“…Akt activation in human cancers exerts chemoresistance, but pan-Akt inhibition elicits adverse consequences. We exploited the consequences of Akt-mediated…”
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Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity by Hahn-Windgassen, Annett, Nogueira, Veronique, Chen, Chia-Chen, Skeen, Jennifer E., Sonenberg, Nahum, Hay, Nissim

“…The serine/threonine kinase Akt is an upstream positive regulator of the mammalian target of rapamycin (mTOR). However, the mechanism by which Akt activates…”
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FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor by Chen, Chia-Chen, Jeon, Sang-Min, Bhaskar, Prashanth T., Nogueira, Veronique, Sundararajan, Deepa, Tonic, Ivana, Park, Youngkyu, Hay, Nissim

“…FoxO transcription factors and TORC1 are conserved downstream effectors of Akt. Here, we unraveled regulatory circuits underlying the interplay between Akt,…”
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Hexokinase-Mitochondria Interaction Mediated by Akt Is Required to Inhibit Apoptosis in the Presence or Absence of Bax and Bak by Majewski, Nathan, Nogueira, Veronique, Bhaskar, Prashanth, Coy, Platina E., Skeen, Jennifer E., Gottlob, Kathrin, Chandel, Navdeep S., Thompson, Craig B., Robey, R.Brooks, Hay, Nissim

“…The serine/threonine kinase Akt inhibits mitochondrial cytochrome c release and apoptosis induced by a variety of proapoptotic stimuli. The antiapoptotic…”
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Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner by Skeen, Jennifer E., Bhaskar, Prashanth T., Chen, Chia-Chen, Chen, William S., Peng, Xiao-ding, Nogueira, Veronique, Hahn-Windgassen, Annett, Kiyokawa, Hiroaki, Hay, Nissim

“…Akt contributes to tumorigenesis by inhibiting apoptosis. Here we establish that Akt is required for normal cell proliferation and susceptibility to…”
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Akt Inhibits Apoptosis Downstream of BID Cleavage via a Glucose-Dependent Mechanism Involving Mitochondrial Hexokinases by Majewski, Nathan, Nogueira, Veronique, Robey, R. Brooks, Hay, Nissim

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Author Correction: Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin by DeWaal, Dannielle, Nogueira, Veronique, Terry, Alexander R., Patra, Krushna C., Jeon, Sang-Min, Guzman, Grace, Au, Jennifer, Long, Christopher P., Antoniewicz, Maciek R., Hay, Nissim

“…In the originally published version of this Article, the colours of the bars in Fig. 4b were inadvertently switched during the production process, such that…”
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mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3β Inhibition by Bhaskar, Prashanth T., Nogueira, Veronique, Patra, Krushna C., Jeon, Sang-Min, Park, Youngkyu, Robey, R. Brooks, Hay, Nissim

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Systemic Akt1 Deletion after Tumor Onset in p53−/− Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration by Yu, Wan-Ni, Nogueira, Veronique, Sobhakumari, Arya, Patra, Krushna C., Bhaskar, Prashanth T., Hay, Nissim

“…Akt is frequently activated in human cancers. However, it is unknown whether systemic inhibition of a single Akt isoform could regress cancer progression in…”
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Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis by Nogueira, Veronique, Park, Youngkyu, Chen, Chia-Chen, Xu, Pei-Zhang, Chen, Mei-Ling, Tonic, Ivana, Unterman, Terry, Hay, Nissim

“…Akt deficiency causes resistance to replicative senescence, to oxidative stress- and oncogenic Ras-induced premature senescence, and to reactive oxygen species…”
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Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I by El-Mir, M Y, Nogueira, V, Fontaine, E, Avéret, N, Rigoulet, M, Leverve, X

“…We report here a new mitochondrial regulation occurring only in intact cells. We have investigated the effects of dimethylbiguanide on isolated rat…”
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CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression by Terry, Alexander R, Nogueira, Veronique, Rho, Hyunsoo, Ramakrishnan, Gopalakrishnan, Li, Jing, Kang, Soeun, Pathmasiri, Koralege C, Bhat, Sameer Ahmed, Jiang, Liping, Kuchay, Shafi, Cologna, Stephanie M, Hay, Nissim

“…A high-fat diet (HFD) promotes metastasis through increased uptake of saturated fatty acids (SFAs). The fatty acid transporter CD36 has been implicated in this…”
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Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-κB signaling pathways by Wang, Zhiwei, Li, Yiwei, Banerjee, Sanjeev, Kong, Dejuan, Ahmad, Aamir, Nogueira, Veronique, Hay, Nissim, Sarkar, Fazlul H

“…Notch signaling is involved in a variety of cellular processes, such as cell fate specification, differentiation, proliferation, and survival. Notch‐1…”
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Cell-Autonomous versus Systemic Akt Isoform Deletions Uncovered New Roles for Akt1 and Akt2 in Breast Cancer by Chen, Xinyu, Ariss, Majd M., Ramakrishnan, Gopalakrishnan, Nogueira, Veronique, Blaha, Catherine, Putzbach, William, Islam, Abul B.M.M.K., Frolov, Maxim V., Hay, Nissim

“…Studies in three mouse models of breast cancer identified profound discrepancies between cell-autonomous and systemic Akt1- or Akt2-inducible deletion on…”
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FoxM1, a critical regulator of oxidative stress during oncogenesis by Park, Hyun Jung, Carr, Janai R, Wang, Zebin, Nogueira, Veronique, Hay, Nissim, Tyner, Angela L, Lau, Lester F, Costa, Robert H, Raychaudhuri, Pradip

“…The transcription factor FoxM1 is over‐expressed in most human malignancies. Although it is evident that FoxM1 has critical functions in tumour development and…”
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Combination of Oxidative Stress and FOXM1 Inhibitors Induces Apoptosis in Cancer Cells and Inhibits Xenograft Tumor Growth by Halasi, Marianna, Pandit, Bulbul, Wang, Ming, Nogueira, Veronique, Hay, Nissim, Gartel, Andrei L

“…Tumor cells accumulate high level of reactive oxygen species (ROS) because they are metabolically more active than normal cells. Elevated ROS levels increase…”
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Three Classes of Ubiquinone Analogs Regulate the Mitochondrial Permeability Transition Pore through a Common Site by Walter, Ludivine, Nogueira, Véronique, Leverve, Xavier, Heitz, Marie-Paule, Bernardi, Paolo, Fontaine, Eric

“…To identify the structural features required for regulation of the mitochondrial permeability transition pore (PTP) by ubiquinone analogs (Fontaine, E., Ichas,…”
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