New indices in predicting cardiometabolic risk and its relation to endothelial dysfunction in adolescents: The HELENA study

New indices in predicting cardiometabolic risk and its relation to endothelial dysfunction in adolescents: The HELENA study

Blood pressure (BP) changes and insulin resistance (IR) are important cardiometabolic risk (CMR) factors; their early identification can contribute to the reduction of cardiovascular events in adulthood. This necessitates the search for more accessible and easily applied indicators for their predict...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases Vol. 33; no. 5; pp. 1037 - 1048
Main Authors: Nogueira, Maria D.A., Braga, Ribanna A.M., Manios, Yannis, Androutsos, Odysseas, Molnár, Dénes, Polito, Angela, Gómez-Martínez, Sonia, Béghin, Laurent, Widhalm, Kurt, Bueno, Gloria, Castillo, Manuel J., De Henauw, Stefaan, Moreno, Luis A., Maia, Carla S.C.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-05-2023
Elsevier
Series:Nutrition, Metabolism and Cardiovascular Diseases
Subjects:
Adolescent
Adolescents
Biomarkers
Blood pressure
Body Mass Index
Cardiovascular health
Cross-Sectional Studies
Endothelium
Female
Humans
Hypertension
Insulin Resistance
Life Sciences
Male
Triglycerides
APO
TyG
DM
sE-selectin
sVCAM-1
WC
Cardiovascular health
BP
sICAM-1
HLAP
DBP
L-selectin
Blood pressure
SPSS
VLDL-c
Adolescents
BMI
ED
SBP
IL
LDL-c
ROC
CMR
IR
Endothelium
TC
CVD
HDL-c
HOMA-IR
TG
TNF-α
hsCRP
Insulin resistance
LAP
HELENA-CSS
CVR
VAI
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Blood pressure (BP) changes and insulin resistance (IR) are important cardiometabolic risk (CMR) factors; their early identification can contribute to the reduction of cardiovascular events in adulthood. This necessitates the search for more accessible and easily applied indicators for their prediction. Therefore, this study aimed to evaluate the predictive power of the indices, TyG, TG/HDL-c, height-corrected lipid accumulation product (HLAP), and visceral adiposity index (VAI), in identifying the CMR obtained by high BP and IR and to verify their relationship with biomarkers of endothelial dysfunction (ED) in European adolescents. The anthropometric data and blood biomarkers of 744 adolescents (343 boys and 401 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study (HELENA-CSS), with a mean age of 14.67 (SD 1.15) years, were assessed. The adolescents were then classified according to the presence or absence of high BP and IR. The cut-off points of the indices evaluated for the identification of CMR were determined. The relationship between CMR diagnosed using these indices and ED biomarkers was tested. The HLAP and TG/HDL-c were fair predictors of CMR obtained by IR in male adolescents. These indices showed association with hsCRP in sVCAM-1 in boys, but it lost significance after adjusting for age and body mass index. TG/HDL-c and HLAP indices showed a fair performance in predicting CMR, obtained by IR, in male adolescents. ED showed no association with the CMR identified by the indices. •High blood pressure was considered cardiometabolic risk (CMR) indicator.•Insulin resistance was considered a CMR indicator.•Cut-off points for the prediction of CMR were identified for each index.•The HLAP and TG/HDL-c indices were fair predictors of CMR.•Endothelial dysfunction was not associated with CMR identified by the indices.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2023.01.015