Investigation of genotoxic and antigenotoxic activities of Melampodium divaricatum in Salmonella typhimurium

Melampodium divaricatum is a member of the Asteraceae and in Brazil is known as false-calendula, its flowers being used in anti-inflammatory preparations, substituting the true calendula or marigold ( Calendula officinalis L.). The flower extract was investigated for mutagenic and antimutagenic effe...

Full description

Saved in:

Bibliographic Details
Published in:	Toxicology in vitro Vol. 20; no. 3; pp. 361 - 366
Main Authors:	Nogueira, Maira Eiko Ikuma, Passoni, Mariana Henrique, Biso, Fabiana Izilda, Longo, Maria do Carmo, Cardoso, Cássia Regina Primila, Santos, Lourdes Campaner dos, Varanda, Eliana Aparecida
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-04-2006
Subjects:	Aflatoxin B1 - antagonists & inhibitors Aflatoxin B1 - toxicity Animals Anti-Bacterial Agents - antagonists & inhibitors Anti-Bacterial Agents - toxicity Antimutagenic activity Antimutagenic Agents - pharmacology Asteraceae Asteraceae - chemistry Benzo(a)pyrene - antagonists & inhibitors Benzo(a)pyrene - toxicity Calendula officinalis Chlorophyll - toxicity Chromatography, Thin Layer Daunorubicin - antagonists & inhibitors Daunorubicin - toxicity DNA Damage - drug effects Dose-Response Relationship, Drug Flowers - chemistry Melampodium divaricatum Mutagenicity Tests Mutagens - toxicity Mutation - drug effects Mutation - genetics Plant Extracts - pharmacology Plant Extracts - toxicity Rats Salmonella typhimurium Salmonella typhimurium - drug effects Salmonella typhimurium - genetics Triterpenes Triterpenes - toxicity Brazil Salmonella typhimurium Antimutagenic activity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Melampodium divaricatum is a member of the Asteraceae and in Brazil is known as false-calendula, its flowers being used in anti-inflammatory preparations, substituting the true calendula or marigold ( Calendula officinalis L.). The flower extract was investigated for mutagenic and antimutagenic effect in the Salmonella/microsome assay. The tested extract was not mutagenic in the strains TA100, TA98, TA97a and TA102 and decreased the mutagenicity of aflatoxin B1, benzo( a)pyrene and daunomycin. Chlorophyll and triterpenes were detected in the extract, and they might have contributed to the observed effect. Our data suggest that these medicinal plants possess cancer chemopreventive properties.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0887-2333 1879-3177
DOI:	10.1016/j.tiv.2005.08.012