Search Results - "Nogle, Lisa M."

Somocystinamide A, a Novel Cytotoxic Disulfide Dimer from a Fijian Marine Cyanobacterial Mixed Assemblage by Nogle, Lisa M, Gerwick, William H

“…Bioassay-guided investigation of the extract from a Lyngbya majuscula/Schizothrix sp. assemblage of marine cyanobacteria led to the discovery of…”
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Isolation of Four New Cyclic Depsipeptides, Antanapeptins A−D, and Dolastatin 16 from a Madagascan Collection of Lyngbya majuscula by NOGLE, Lisa M., GERWICK, William H.

“…Examination of a Lyngbya majuscula collection from Antany Mora, Madagascar, led to the isolation of dolastatin 16 (5), a promising antineoplastic metabolite…”
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General Synthesis of Conformationally Constrained Noncanonical Amino Acids with C(sp 3)‑Rich Benzene Bioisosteres by Ma, Xiaoshen, Beard, Adam M., Burgess, Samantha A., Darlak, Miroslawa, Newman, Justin A., Nogle, Lisa M., Pietrafitta, Mark J., Smith, David A., Wang, Xiao, Yue, Lei

“…Recent years have seen novel modalities emerge for the treatment of human diseases resulting in an increase in beyond rule of 5 (bRo5) chemical matter. As a…”
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Diverse Secondary Metabolites from a Puerto Rican Collection of Lyngbya majuscula by NOGLE, Lisa M., GERWICK, William H.

“…Extensive fractionation of the crude organic extract from a Puerto Rican collection of Lyngbya majuscula led to the discovery of three new secondary…”
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Antillatoxin B, a Neurotoxic Lipopeptide from the Marine Cyanobacterium Lyngbya majuscula by NOGLE, Lisa M., OKINO, Tatsufumi, GERWICK, William H.

“…Bioassay-guided fractionation of organic extracts from two Lyngbya majuscula collections led to the isolation of a new secondary metabolite, antillatoxin B, an…”
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Desmethoxymajusculamide C, a Cyanobacterial Depsipeptide with Potent Cytotoxicity in Both Cyclic and Ring-Opened Forms by Simmons, T. Luke, Nogle, Lisa M, Media, Joseph, Valeriote, Frederick A, Mooberry, Susan L, Gerwick, William H

“…Cytotoxicity-guided fractionation of the organic extract from a Fijian Lyngbya majuscula led to the discovery of desmethoxymajusculamide C (DMMC) as the active…”
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Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula by Edwards, Daniel J, Marquez, Brian L, Nogle, Lisa M, McPhail, Kerry, Goeger, Douglas E, Roberts, Mary Ann, Gerwick, William H

“…A screening program for bioactive compounds from marine cyanobacteria led to the isolation of jamaicamides A–C. Jamaicamide A is a novel and highly…”
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Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists by Crombie, Aimee L., Antrilli, Thomas M., Campbell, Brandon A., Crandall, David L., Failli, Amedeo A., He, Yanan, Kern, Jeffrey C., Moore, William J., Nogle, Lisa M., Trybulski, Eugene J.

“…A series of biaryl amides containing an azabicyclo[3.2.1]octane amine headpiece were synthesized and evaluated as mixed arginine vasopressin (AVP) receptor…”
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Preparative separation and identification of derivatized β-methylphenylalanine enantiomers by chiral SFC, HPLC and NMR for development of new peptide ligand mimetics in drug discovery by Nogle, Lisa M., Mann, Charles W., Watts, William L., Zhang, Yingru

“…A direct preparative purification of all four isomers of the unnatural amino acid β-methylphenylalanine was achieved using supercritical fluid chromatography…”
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Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1 H-indol-1-yl)-3-arylpropan-1-amines by Mahaney, Paige E., Vu, An T., McComas, Casey C., Zhang, Puwen, Nogle, Lisa M., Watts, William L., Sarkahian, Ani, Leventhal, Liza, Sullivan, Nicole R., Uveges, Albert J., Trybulski, Eugene J.

“…Compounds with a combination of norepinephrine and serotonin reuptake inhibition have been approved in the US and Europe for a number of indications, including…”
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Structure, Synthesis, and Biological Properties of Kalkitoxin, a Novel Neurotoxin from the Marine Cyanobacterium Lyngbya majuscula by WU, Min, OKINO, Tatsufumi, NOGLE, Lisa M., MARQUEZ, Brian L., WILLIAMSON, R. Thomas, SITACHITTA, Namthip, BERMAN, Frederick W., MURRAY, Thomas F., MCGOUGH, Kevin, JACOBS, Robert, COLSEN, Kimberly, ASANO, Toshinobu, YOKOKAWA, Fumiaki, SHIOIRI, Takayuki, GERWICK, William H.

“…Cyanobacteria from a diversity of marine and freshwater habitats are known to produce neurotoxic secondary metabolites. Herein, we describe the complete…”
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Wewakazole, a novel cyclic dodecapeptide from a Papua New Guinea Lyngbya majuscula by Nogle, Lisa M, Marquez, Brian L, Gerwick, William H

“…Phytochemical examination of a Papua New Guinea collection of Lyngbya majuscula resulted in the discovery of wewakazole (1), a novel cyclic dodecapeptide…”
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Sub-2 μm HPLC coupled with sub-ppm mass accuracy for analysis of pharmaceutical compound libraries by Stroh, Justin G, Petucci, Christopher J, Brecker, Scott J, Nogle, Lisa M

“…Recent advances in accurate mass analysis are poised to allow the high-throughput production of accurate mass data on many more compounds than was previously…”
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Somamides A and B, Two New Depsipeptide Analogues of Dolastatin 13 from a Fijian Cyanobacterial Assemblage of Lyngbya majuscula and Schizothrix Species by NOGLE, Lisa M., WILLIAMSON, R. Thomas, GERWICK, William H.

“…Somamides A (1) and B (2) were isolated from assemblages of the marine cyanobacteria Lyngbya majusculaand Schizothrix sp. from the Fijian Islands. These new…”
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Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter by Gavrin, Lori K, Mahaney, Paige E, Jenkins, Douglas, Nogle, Lisa M, Mugford, Cheryl A, Huselton, Christine, Leiter, Jennifer, Johnston, Grace H, Bray, Jenifer A, Burroughs, Kevin D, Cosmi, Scott A, Alfinito, Peter, Ho, Douglas M, Deecher, Darlene C, Trybulski, Eugene J

“…The potency and selectivity of a series of 1-{(1S)-2-[amino]-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol analogues are described. These compounds were…”
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Diverse Secondary Metabolites from a Puerto Rican Collection of Lyngbya m ajuscula by Nogle, Lisa M, Gerwick, William H

“…Extensive fractionation of the crude organic extract from a Puerto Rican collection of Lyngbya majuscula led to the discovery of three new secondary…”
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Isolation of Four New Cyclic Depsipeptides, Antanapeptins A−D, and Dolastatin 16 from a Madagascan Collection of Lyngbya m ajuscula by Nogle, Lisa M, Gerwick, William H

“…Examination of a Lyngbya majuscula collection from Antany Mora, Madagascar, led to the isolation of dolastatin 16 (5), a promising antineoplastic metabolite…”
Get full text

Antillatoxin B, a Neurotoxic Lipopeptide from the Marine Cyanobacterium Lyngbya m ajuscula by Nogle, Lisa M, Okino, Tatsufumi, Gerwick, William H

“…Bioassay-guided fractionation of organic extracts from two Lyngbya majuscula collections led to the isolation of a new secondary metabolite, antillatoxin B, an…”
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Somamides A and B, Two New Depsipeptide Analogues of Dolastatin 13 from a Fijian Cyanobacterial Assemblage of Lyngbya m ajuscula and Schizothrix Species by Nogle, Lisa M, Williamson, R. Thomas, Gerwick, William H

“…Somamides A (1) and B (2) were isolated from assemblages of the marine cyanobacteria Lyngbya majuscula and Schizothrix sp. from the Fijian Islands. These new…”
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Abstract 297: Innovation in delivering synthetically challenging bicyclic arginase inhibitors to enhance immunotherapy by Li, Derun, Zhang, Hongjun, Lyons, Thomas W., Martinot, Theodore A., Achab, Abdelghani, lu, Min, Nogle, Lisa M., McMinn, Spencer, Mitcheltree, Matthew J., Childers, Matthew, Pu, Qinglin, Gathiaka, Symon, Palani, Anand, Chakravarthy, Kalyan, DeCastro, Amy D., O'Neil, Jennifer, Afshar, Roshi, Walsh, Nicole C., Fan, Peter W., Cheng, Mangeng, Miller, Richard, Doty, Amy, Palte, Rachel, Kim, Hai-Young, Saurí, Josep, Beard, Adam, Brynczka, Christopher, Fischer, Christian

“…Abstract Arginase overexpression has been associated with poor survival rates in advanced cancer patients treated with Keytruda. High levels of Arginase may…”
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