Serum leptin levels correlate with hepatic steatosis in chronic hepatitis C

Hepatic steatosis (HS) has been related to obesity and fibrosis in chronic hepatitis C (CHC). The aim of this study was to determine the role of leptin system in HS development. Patients (n = 131) with biopsy-proven CHC, positive HCV RNA, and raised ALT were enrolled. Body mass index, percentage of...

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Bibliographic Details
Published in:	The American journal of gastroenterology Vol. 98; no. 5; pp. 1135 - 1141
Main Authors:	Romero-Gómez, Manuel, Castellano-Megias, Victor M, Grande, Lourdes, Irles, José A, Cruz, Marina, Nogales, Marí Carmen, Alcón, Juan Carlos, Robles, Antonio
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Inc 01-05-2003 Blackwell Publishing
Subjects:	Adult Alcohol Drinking Biological and medical sciences Body Mass Index Clinical Trials as Topic Fatty Liver - blood Fatty Liver - physiopathology Female Fibrosis - etiology Fibrosis - pathology Genotype Hepacivirus - isolation & purification Hepatitis C, Chronic - blood Hepatitis C, Chronic - physiopathology Human viral diseases Humans Infectious diseases Leptin - blood Liver Cirrhosis - blood Liver Cirrhosis - physiopathology Liver Function Tests Male Medical sciences Multivariate Analysis Polymerase Chain Reaction Regression Analysis RNA, Viral - analysis Viral diseases Viral hepatitis Viral Load Human Liver Hepatic disease Genotype Triglyceride Statistical study Steatosis Infection Virus Chronic Viral disease Leptin Digestive diseases Complication Flaviviridae Predictive factor Hepatitis C virus Hepacivirus Quantitative analysis Viral hepatitis C
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Summary:	Hepatic steatosis (HS) has been related to obesity and fibrosis in chronic hepatitis C (CHC). The aim of this study was to determine the role of leptin system in HS development. Patients (n = 131) with biopsy-proven CHC, positive HCV RNA, and raised ALT were enrolled. Body mass index, percentage of body fat by skin fold measurement, and bioelectrical impedance analysis was calculated and serum leptin concentration measured. Intrahepatic HCV RNA, HS, necroinflammatory activity, and fibrosis were determined in liver biopsy tissue. HS was present in 63 patients (48.1%). Steatosis was evident in 32 of 91 patients (35.2%) infected with genotype 1 and in 22 of 27 patients (81.5%) with genotype 3a ( p < 0.001). In patients infected by genotype 3a, HS correlated significantly with intrahepatic HCV RNA load ( r = 0.78; p < 0.001). However, in genotype 1, HS was associated with host factors such as leptin, body mass index, percentage of body fat, and visceral obesity. Multivariate analysis showed genotype (OR = 11.54, 95% CI = 1.13–117.14, p = 0.038), leptin levels (OR = 1.09, 95% CI = 1.03–1.17, p = 0.008) and fibrosis (OR = 9.86, 95% CI = 2.11–5.86, p = 0.03) as independent variables of HS development. Hepatic steatosis was related to genotype, fibrosis degree, and serum leptin levels. Genotype 3 seems to have a viral specific steatogenic effect. Leptin seems to be a link between obesity and steatosis development in CHC genotype 1–infected patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9270 1572-0241
DOI:	10.1016/S0002-9270(03)00185-0