Search Results - "Nogal‐Ruiz, Juan José"

Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2‐Benzyl‐5‐nitroindazole‐Derived Amines by Fonseca‐Berzal, Cristina, Ibáñez‐Escribano, Alexandra, Vela, Nerea, Cumella, José, Nogal‐Ruiz, Juan José, Escario, José Antonio, da Silva, Patrícia Bernardino, Batista, Marcos Meuser, Soeiro, Maria de Nazaré C., Sifontes‐Rodríguez, Sergio, Meneses‐Marcel, Alfredo, Gómez‐Barrio, Alicia, Arán, Vicente J.

“…Three different series of new 5‐nitroindazole derivatives—1‐(ω‐aminoalkyl)‐2‐benzylindazolin‐3‐ones (series A; ten compounds),…”
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Sequestration of host-CD59 as potential immune evasion strategy of Trichomonas vaginalis by Ibáñez-Escribano, Alexandra, Nogal-Ruiz, Juan José, Pérez-Serrano, Jorge, Gómez-Barrio, Alicia, Escario, J. Antonio, Alderete, J.F.

“…•No sequence homology in Trichomonas vaginalis genome with CD59 human gene.•IFI detection of CD59 on T. vaginalis surface of flagellates recovered from…”
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Validation of a modified fluorimetric assay for the screening of trichomonacidal drugs by Escribano, Alexandra Ibáñez, Marcel, Alfredo Meneses, Tugores, Yanetsy Machado, Ruiz, Juan José Nogal, Redó, Vicente J Arán, García-Trevijano, José Antonio Escario, Barrio, Alicia Gómez

“…A fluorimetric microassay that uses a redox dye to determine the viability of the flagellate Trichomonas vaginalis has been optimised to provide a more…”
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Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles by Ibáñez-Escribano, Alexandra, Reviriego, Felipe, Vela, Nerea, Fonseca-Berzal, Cristina, Nogal-Ruiz, Juan José, Arán, Vicente J., Escario, José Antonio, Gómez-Barrio, Alicia

“…[Display omitted] A series of 11 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles (2–12) has been prepared starting from 1-benzyl-5-nitroindazol-3-ol 13, and…”
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The Past, Present, and Future in the Diagnosis of a Neglected Sexually Transmitted Infection: Trichomoniasis by Ibáñez-Escribano, Alexandra, Nogal-Ruiz, Juan José

“…More than one million curable sexually transmitted infections occur every day. is one of the main infections responsible for these epidemiological data;…”
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Synthesis and Evaluation of 1,1′-Hydrocarbylenebis(indazol-3-ols) as Potential Antimalarial Drugs by Martins Alho, Miriam, García-Sánchez, Rory N., Nogal-Ruiz, Juan José, Escario, José Antonio, Gómez-Barrio, Alicia, Martínez-Fernández, Antonio R., Arán, Vicente J.

“…Bis(indazol‐3‐ol) derivatives (5, 30–38) were prepared by alkylation of 3‐alkoxyindazoles with α,ω‐dibromides, followed by removal of the O‐protecting groups…”
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In vitro trichomonacidal activity and preliminary in silico chemometric studies of 5-nitroindazolin-3-one and 3-alkoxy-5-nitroindazole derivatives by Ibáñez-Escribano, Alexandra, Nogal-Ruiz, Juan José, Gómez-Barrio, Alicia, Arán, Vicente J, Escario, José Antonio

“…A selection of 1,2-disubstituted 5-nitroindazolin-3-ones (1-19) and 3-alkoxy-5-nitroindazoles substituted at positions 1 (20-24) or 2 (25-39) from our in-house…”
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A sequential procedure for rapid and accurate identification of putative trichomonacidal agents by Ibáñez-Escribano, Alexandra, Meneses-Marcel, Alfredo, Marrero-Ponce, Yovani, Nogal-Ruiz, Juan José, Arán, Vicente J., Gómez-Barrio, Alicia, Escario, José Antonio

“…In the current report, a sequential step-wise methodology based on in silico, in vitro and in vivo experimental procedures for the prompt detection of…”
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A linear discrimination analysis based virtual screening of trichomonacidal lead-like compounds: Outcomes of in silico studies supported by experimental results by Meneses-Marcel, Alfredo, Marrero-Ponce, Yovani, Machado-Tugores, Yanetsy, Montero-Torres, Alina, Pereira, David Montero, Escario, José Antonio, Nogal-Ruiz, Juan José, Ochoa, Carmen, Arán, Vicente J., Martínez-Fernández, Antonio R., García Sánchez, Rory N.

“…A computational (virtual) screening test to identify potential trichomonacidals has been developed. Molecular structures of trichomonacidal and…”
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Predicting antitrichomonal activity: A computational screening using atom-based bilinear indices and experimental proofs by Marrero-Ponce, Yovani, Meneses-Marcel, Alfredo, Castillo-Garit, Juan A., Machado-Tugores, Yanetsy, Escario, José Antonio, Barrio, Alicia Gómez, Pereira, David Montero, Nogal-Ruiz, Juan José, Arán, Vicente J., Martínez-Fernández, Antonio R., Torrens, Francisco, Rotondo, Richard, Ibarra-Velarde, Froylán, Alvarado, Ysaias J.

“…The two dimensions of TOMOCOMD-CARDD method: from dataset to QSAR models, and from QSAR models to biosilico drug discovery. Existing Trichomonas vaginalis…”
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Determination of internal transcribed spacer regions (ITS) in Trichomonas vaginalis isolates and differentiation among Trichomonas species by Ibáñez-Escribano, Alexandra, Nogal-Ruiz, Juan José, Arán, Vicente J, Escario, José Antonio, Gómez-Barrio, Alicia, Alderete, J.F

“…Abstract The nucleotide sequence of the 5.8S rRNA gene and the flanked internal transcribed spacer (ITS) regions of six Trichomonas vaginalis isolates with…”
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Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles by Fonseca-Berzal, Cristina, Ibáñez-Escribano, Alexandra, Reviriego, Felipe, Cumella, José, Morales, Paula, Jagerovic, Nadine, Nogal-Ruiz, Juan José, Escario, José Antonio, da Silva, Patricia Bernardino, Soeiro, Maria de Nazaré C., Gómez-Barrio, Alicia, Arán, Vicente J.

“…Two series of new 5-nitroindazole derivatives, 1-substituted 2-benzylindazolin-3-ones (6–29, series A) and 3-alkoxy-2-benzyl-2H-indazoles (30–37, series B),…”
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Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents by Ibáñez-Escribano, Alexandra, Reviriego, Felipe, Nogal-Ruiz, Juan José, Meneses-Marcel, Alfredo, Gómez-Barrio, Alicia, Escario, José Antonio, Arán, Vicente J.

“…Two series of ten novel 7-nitroquinoxalin-2-ones and ten 6-nitroquinoxaline-2,3-diones with diverse substituents at positions 1 and 4 were synthesized and…”
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Trichinella: Differing effects of antigens from encapsulated and non-encapsulated species on in vitro nitric oxide production by Andrade, M. Amparo, Siles-Lucas, Mar, López-Abán, Julio, Nogal-Ruiz, Juan José, Pérez-Arellano, José Luis, Martínez-Fernández, Antonio R., Muro, Antonio

“…Trichinellosis is a cosmopolitan zoonotic disease affecting a wide variety of animals, including man. Non-encapsulated and encapsulated species diverge with…”
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Trichomonacidal Activity of 3,3′-Diindolylmethane (DIM) Is Additive to Metronidazole (MTZ) In Vitro, Supporting Future Oral/Topical Use by Alexandra Ibáñez-Escribano, Leyre Pernaute Lau, Juan José Nogal-Ruiz, Alicia Gómez-Barrio, Jose Antonio Escario, Michael A. Zeligs

“…New, safe, well tolerated, and versatile anti-trichomonal agents for oral and topical use are needed to combat spreading resistance of Trichomonas vaginalis to…”
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Immunomodulation of the Response to Excretory/Secretory Antigens of Fasciola hepatica by Anapsos® in Balb/C Mice and Rat Alveolar Macrophages by López-Abán, Julio, Andrade, Maria do Amparo, Nogal-Ruiz, Juan José, Martínez-Fernández, Antonio R, Muro, Antonio

“…It is known that excretory/secretory antigens of Fasciola hepatica (ESFh) trigger a Th2-like immune response. Anapsos® (A) is an aqueous hydrosoluble extract…”
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A computer-based approach to the rational discovery of new trichomonacidal drugs by atom-type linear indices by Marrero-Ponce, Yovani, Machado-Tugores, Yanetsy, Pereira, David Montero, Escario, José Antonio, Barrio, Alicia Gómez, Nogal-Ruiz, Juan José, Ochoa, Carmen, Arán, Vicente J, Martínez-Fernández, Antonio R, Sánchez, Rory N García, Montero-Torres, Alina, Torrens, Francisco, Meneses-Marcel, Alfredo

“…Computational approaches are developed to design or rationally select, from structural databases, new lead trichomonacidal compounds. First, a data set of 111…”
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