Search Results - "Noerager, Brett D."

Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung by Genschmer, Kristopher R., Russell, Derek W., Lal, Charitharth, Szul, Tomasz, Bratcher, Preston E., Noerager, Brett D., Abdul Roda, Mojtaba, Xu, Xin, Rezonzew, Gabriel, Viera, Liliana, Dobosh, Brian S., Margaroli, Camilla, Abdalla, Tarek H., King, Robert W., McNicholas, Carmel M., Wells, J. Michael, Dransfield, Mark T., Tirouvanziam, Rabindra, Gaggar, Amit, Blalock, J. Edwin

“…Here, we describe a novel pathogenic entity, the activated PMN (polymorphonuclear leukocyte, i.e., neutrophil)-derived exosome. These CD63+/CD66b+ nanovesicles…”
Get full text

A Critical Role for LTA₄H in Limiting Chronic Pulmonary Neutrophilic Inflammation by Snelgrove, Robert J., Jackson, Patricia L., Hardison, Matthew T., Noerager, Brett D., Kinloch, Andrew, Gaggar, Amit, Shastry, Suresh, Rowe, Steven M., Shim, Yun M., Hussell, Tracy, Blalock, J. Edwin

“…Leukotriene A₄ hydrolase (LTA₄H) is a proinflammatory enzyme that generates the inflammatory mediator leukotriene B₄ (LTB₄). LTA₄H also possesses…”
Get full text

A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation by Gaggar, Amit, Jackson, Patricia L, Noerager, Brett D, O'Reilly, Philip J, McQuaid, D. Brent, Rowe, Steven M, Clancy, J. P, Blalock, J. Edwin

“…Chronic neutrophilic inflammation is a manifestation of a variety of lung diseases including cystic fibrosis (CF). There is increasing evidence that fragments…”
Get full text

Potential Role of High-Mobility Group Box 1 in Cystic Fibrosis Airway Disease by Rowe, Steven M, Jackson, Patricia L, Liu, Gang, Hardison, Mathew, Livraghi, Alessandra, Solomon, G. Martin, McQuaid, D. Brent, Noerager, Brett D, Gaggar, Amit, Clancy, J. P, O'Neal, Wanda, Sorscher, Eric J, Abraham, Edward, Blalock, J. Edwin

“…High-mobility group box 1 (HMGB1) is a potent inflammatory mediator elevated in sepsis and rheumatoid arthritis, although its role in cystic fibrosis (CF) lung…”
Get full text

A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation by Blalock, J Edwin, Weathington, Nathaniel M, van Houwelingen, Anneke H, Noerager, Brett D, Jackson, Patricia L, Kraneveld, Aletta D, Galin, F Shawn, Folkerts, Gert, Nijkamp, Frans P

“…We describe the tripeptide neutrophil chemoattractant N-acetyl Pro-Gly-Pro (PGP), derived from the breakdown of extracellular matrix (ECM), which shares…”
Get full text

A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation by Noerager, Brett D., Xu, Xin, Davis, Virginia A., Jones, Caleb W., Okafor, Svetlana, Whitehead, Alicia, Blalock, J. Edwin, Jackson, Patricia L.

“…Neutrophils (PMNs) are key mediators of inflammatory processes throughout the body. In this study, we investigated the role of acrolein, a highly reactive…”
Get full text

A CXCL8 receptor antagonist based on the structure of N-acetyl-proline-glycine-proline by Jackson, Patricia L., Noerager, Brett D., Jablonsky, Michael J., Hardison, Matthew T., Cox, Bryan D., Patterson, James C., Dhanapal, Boopathy, Blalock, J. Edwin, Muccio, Donald D.

“…A role for the collagen-derived tripeptide, N-acetyl proline-glycine-proline (NAc-PGP), in neutrophil recruitment in chronic airway inflammatory diseases,…”
Get full text

Possible therapeutic vaccines for canine myasthenia gravis: Implications for the human disease and associated fatigue by Galin, F. Shawn, Chrisman, Cheryl L, Cook, James R, Xu, Likang, Jackson, Patricia L, Noerager, Brett D, Weathington, Nathaniel M, Blalock, J. Edwin

“…Abstract Myasthenia gravis (MG) is caused by T cell-dependent antibodies reactive with acetylcholine receptors. These autoreactive antibodies cause muscle…”
Get full text

Weathington et al. reply by Weathington, Nathaniel M, van Houwelingen, Anneke H, Noerager, Brett D, Jackson, Patricia L, Kraneveld, Aletta D, Galin, F Shawn, Folkerts, Gert, Nijkamp, Frans P, Blalock, J Edwin

Get full text

A Critical Role for LTA 4 H in Limiting Chronic Pulmonary Neutrophilic Inflammation by Snelgrove, Robert J., Jackson, Patricia L., Hardison, Matthew T., Noerager, Brett D., Kinloch, Andrew, Gaggar, Amit, Shastry, Suresh, Rowe, Steven M., Shim, Yun M., Hussell, Tracy, Blalock, J. Edwin

“…Smoke Gets in Your Lungs Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the United States, primarily caused by cigarette smoking…”
Get full text

A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation by SNELGROVE, Robert J, JACKSON, Patricia L, BLALOCK, J. Edwin, HARDISON, Matthew T, NOERAGER, Brett D, KINLOCH, Andrew, GAGGAR, Amit, SHASTRY, Suresh, ROWE, Steven M, SHIM, Yun M, HUSSELL, Tracy

Get full text

Visual response latencies of magnocellular and parvocellular LGN neurons in macaque monkeys by Maunsell, J H, Ghose, G M, Assad, J A, McAdams, C J, Boudreau, C E, Noerager, B D

“…Signals relayed through the magnocellular layers of the LGN travel on axons with faster conduction speeds than those relayed through the parvocellular layers…”
Get more information

A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation1,2 by Gaggar, Amit, Jackson, Patricia L., Noerager, Brett D., O’Reilly, Philip J., McQuaid, D. Brent, Rowe, Steven M., Clancy, J. P., Blalock, J. Edwin

“…Chronic neutrophilic inflammation is a manifestation of a variety of lung diseases including cystic fibrosis (CF). There is increasing evidence that fragments…”
Get full text

An IgM anti-MBP Ab in a case of Waldenstrom’s macroglobulinemia with polyneuropathy expressing an idiotype reactive with an MBP epitope immunodominant in MS and EAE by Noerager, Brett D., Inuzuka, Takashi, Kira, Jun-ichi, Blalock, J.Edwin, Whitaker, John N., Galin, F.Shawn

“…In a previously described case of Waldenstrom’s Macroglobulinemia, complicated by polyneuropathy, the IgM/λ monoclonal antibody (mAb) was highly reactive with…”
Get full text