Search Results - "Noelle, Randolph"

Rethinking peripheral T cell tolerance: checkpoints across a T cell’s journey by ElTanbouly, Mohamed A., Noelle, Randolph J.

“…Following their exit from the thymus, T cells are endowed with potent effector functions but must spare host tissue from harm. The fate of these cells is…”
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B7 family checkpoint regulators in immune regulation and disease by Ceeraz, Sabrina, Nowak, Elizabeth C, Noelle, Randolph J

“…Highlights • In the clinic, targeting blocking the CTLA-4 and PD-1 pathway is advantageous in cancer patients. • Preclinical studies show that B7-H4 and B7-H6…”
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Retinoic Acid Is Essential for Th1 Cell Lineage Stability and Prevents Transition to a Th17 Cell Program by Brown, Chrysothemis C., Esterhazy, Daria, Sarde, Aurelien, London, Mariya, Pullabhatla, Venu, Osma-Garcia, Ines, al-Bader, Raya, Ortiz, Carla, Elgueta, Raul, Arno, Matthew, de Rinaldis, Emanuele, Mucida, Daniel, Lord, Graham M., Noelle, Randolph J.

“…CD4+ T cells differentiate into phenotypically distinct T helper cells upon antigenic stimulation. Regulation of plasticity between these CD4+ T-cell lineages…”
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VISTA: A novel immunotherapy target for normalizing innate and adaptive immunity by ElTanbouly, Mohamed A., Croteau, Walburga, Noelle, Randolph J., Lines, J. Louise

“…•We discuss the role of VISTA as a negative checkpoint directing both innate and adaptive immunity.•VISTA is broadly expressed on myeloid and T cells, and…”
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Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators by Le Mercier, Isabelle, Lines, J Louise, Noelle, Randolph J

“…In the last two years, clinical trials with blocking antibodies to the negative checkpoint regulators CTLA-4 and PD-1 have rekindled the hope for cancer…”
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VISTA Regulates the Development of Protective Antitumor Immunity by LE MERCIER, Isabelle, WENNA CHEN, LINES, Janet L, DAY, Maria, JIANNAN LI, SERGENT, Petra, NOELLE, Randolph J, LI WANG

“…V-domain Ig suppressor of T-cell activation (VISTA) is a novel negative checkpoint ligand that is homologous to PD-L1 and suppresses T-cell activation. This…”
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Cellular sources and immune functions of interleukin-9 by Noelle, Randolph J, Nowak, Elizabeth C

“…Interleukin-9 (IL-9) has recently entered the limelight owing to the discovery that it can be produced by multiple T helper cell subsets. This Progress article…”
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Switching off autoimmunity by Laman, Jon D, Molloy, Michael, Noelle, Randolph J

“…Discovered 30 years ago, CD40L antagonists are proving to be powerful autoimmune drugs…”
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Seeing through the dark: New insights into the immune regulatory functions of vitamin A by Brown, Chrysothemis C., Noelle, Randolph J.

“…The importance of vitamin A for host defense is undeniable and the study of its mechanisms is paramount. Of the estimated 250 million preschool children who…”
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Immunoregulatory functions of VISTA by Nowak, Elizabeth C., Lines, J. Louise, Varn, Frederick S., Deng, Jie, Sarde, Aurelien, Mabaera, Rodwell, Kuta, Anna, Le Mercier, Isabelle, Cheng, Chao, Noelle, Randolph J.

“…Summary Utilization of negative checkpoint regulators (NCRs) for cancer immunotherapy has garnered significant interest with the completion of clinical trials…”
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All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation by Benson, Micah J, Pino-Lagos, Karina, Rosemblatt, Mario, Noelle, Randolph J

“…We demonstrate that all-trans retinoic acid (RA) induces FoxP3(+) adaptive T regulatory cells (A-Tregs) to acquire a gut-homing phenotype (alpha 4 beta 7(+) CC…”
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Molecular mechanism and function of CD40/CD40L engagement in the immune system by Elgueta, Raul, Benson, Micah J, de Vries, Victor C, Wasiuk, Anna, Guo, Yanxia, Noelle, Randolph J

“…During the generation of a successful adaptive immune response, multiple molecular signals are required. A primary signal is the binding of cognate antigen to…”
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VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance by ElTanbouly, Mohamed A, Zhao, Yanding, Nowak, Elizabeth, Li, Jiannan, Schaafsma, Evelien, Le Mercier, Isabelle, Ceeraz, Sabrina, Lines, J Louise, Peng, Changwei, Carriere, Catherine, Huang, Xin, Day, Maria, Koehn, Brent, Lee, Sam W, Silva Morales, Milagros, Hogquist, Kristin A, Jameson, Stephen C, Mueller, Daniel, Rothstein, Jay, Blazar, Bruce R, Cheng, Chao, Noelle, Randolph J

“…Negative checkpoint regulators (NCRs) temper the T cell immune response to self-antigens and limit the development of autoimmunity. Unlike all other NCRs that…”
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Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity by Wang, Li, Le Mercier, Isabelle, Putra, Juan, Chen, Wenna, Liu, Jun, Schenk, Austin D., Nowak, Elizabeth C., Suriawinata, Arief A., Li, Jiannan, Noelle, Randolph J.

“…V domain-containing Ig suppressor of T-cell activation (VISTA) is a negative checkpoint regulator that suppresses T cell-mediated immune responses. Previous…”
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VISTA expression on tumor-infiltrating inflammatory cells in primary cutaneous melanoma correlates with poor disease-specific survival by Kuklinski, Lawrence F., Yan, Shaofeng, Li, Zhongze, Fisher, Jan L., Cheng, Chao, Noelle, Randolph J., Angeles, Christina V., Turk, Mary Jo, Ernstoff, Marc S.

“…Adaptive immune responses contribute to the pathogenesis of melanoma by facilitating immune evasion. V-domain Ig suppressor of T-cell activation (VISTA) is a…”
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IL-9 as a mediator of Th17-driven inflammatory disease by Nowak, Elizabeth C, Weaver, Casey T, Turner, Henrietta, Begum-Haque, Sakhina, Becher, Burkhard, Schreiner, Bettina, Coyle, Anthony J, Kasper, Lloyd H, Noelle, Randolph J

“…We report that like other T cells cultured in the presence of transforming growth factor (TGF) beta, Th17 cells also produce interleukin (IL) 9. Th17 cells…”
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Functions of CD40 and Its Ligand, gp39 (CD40L) by Laman, Jon D, Claassen, Eric, Noelle, Randolph J

“…Initially, a role for the interaction between CD40, expressed on B cells, and gp39 (CD40L), expressed on activated T cells, has been defined in humoral…”
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VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses by Wang, Li, Rubinstein, Rotem, Lines, Janet L, Wasiuk, Anna, Ahonen, Cory, Guo, Yanxia, Lu, Li-Fan, Gondek, David, Wang, Yan, Fava, Roy A, Fiser, Andras, Almo, Steve, Noelle, Randolph J

“…The immunoglobulin (Ig) superfamily consists of many critical immune regulators, including the B7 family ligands and receptors. In this study, we identify a…”
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PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype by Fanelli, Giorgia, Romano, Marco, Nova-Lamperti, Estefania, Werner Sunderland, Mariana, Nerviani, Alessandra, Scottà, Cristiano, Bombardieri, Michele, Quezada, Sergio A, Sacks, Steven H, Noelle, Randolph J, Pitzalis, Costantino, Lechler, Robert I, Lombardi, Giovanna, Becker, Pablo D

“…Programmed cell death protein 1 (PD-1) is expressed on T cells upon T cell receptor (TCR) stimulation. PD-1 ligand 1 (PD-L1) is expressed in most tumor…”
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Immune checkpoint receptors in regulating immune reactivity in rheumatic disease by Ceeraz, Sabrina, Nowak, Elizabeth C, Burns, Christopher M, Noelle, Randolph J

“…Immune checkpoint regulators are critical modulators of the immune system, allowing the initiation of a productive immune response and preventing the onset of…”
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