Search Results - "Noe, Mark C"

Delineating the role of cooperativity in the design of potent PROTACs for BTK by Zorba, Adelajda, Nguyen, Chuong, Xu, Yingrong, Starr, Jeremy, Borzilleri, Kris, Smith, James, Zhu, Hongyao, Farley, Kathleen A., Ding, WeiDong, Schiemer, James, Feng, Xidong, Chang, Jeanne S., Uccello, Daniel P., Young, Jennifer A., Garcia-Irrizary, Carmen N., Czabaniuk, Lara, Schuff, Brandon, Oliver, Robert, Montgomery, Justin, Hayward, Matthew M., Coe, Jotham, Chen, Jinshan, Niosi, Mark, Luthra, Suman, Shah, Jaymin C., El-Kattan, Ayman, Qiu, Xiayang, West, Graham M., Noe, Mark C., Shanmugasundaram, Veerabahu, Gilbert, Adam M., Brown, Matthew F., Calabrese, Matthew F.

“…Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that simultaneously bind to a target protein and an E3 ligase, thereby leading…”
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Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors by Flanagan, Mark E, Abramite, Joseph A, Anderson, Dennis P, Aulabaugh, Ann, Dahal, Upendra P, Gilbert, Adam M, Li, Chao, Montgomery, Justin, Oppenheimer, Stacey R, Ryder, Tim, Schuff, Brandon P, Uccello, Daniel P, Walker, Gregory S, Wu, Yan, Brown, Matthew F, Chen, Jinshan M, Hayward, Matthew M, Noe, Mark C, Obach, R. Scott, Philippe, Laurence, Shanmugasundaram, Veerabahu, Shapiro, Michael J, Starr, Jeremy, Stroh, Justin, Che, Ye

“…Interest in drugs that covalently modify their target is driven by the desire for enhanced efficacy that can result from the silencing of enzymatic activity…”
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Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections by Brown, Matthew F, Reilly, Usa, Abramite, Joseph A, Arcari, Joel T, Oliver, Robert, Barham, Rose A, Che, Ye, Chen, Jinshan Michael, Collantes, Elizabeth M, Chung, Seung Won, Desbonnet, Charlene, Doty, Jonathan, Doroski, Matthew, Engtrakul, Juntyma J, Harris, Thomas M, Huband, Michael, Knafels, John D, Leach, Karen L, Liu, Shenping, Marfat, Anthony, Marra, Andrea, McElroy, Eric, Melnick, Michael, Menard, Carol A, Montgomery, Justin I, Mullins, Lisa, Noe, Mark. C, O’Donnell, John, Penzien, Joseph, Plummer, Mark S, Price, Loren M, Shanmugasundaram, Veerabahu, Thoma, Christy, Uccello, Daniel P, Warmus, Joseph S, Wishka, Donn G

“…In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel…”
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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes by Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.

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A Rational Approach to Catalytic Enantioselective Enolate Alkylation Using a Structurally Rigidified and Defined Chiral Quaternary Ammonium Salt under Phase Transfer Conditions by Corey, E. J, Xu, Feng, Noe, Mark C

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Inducing protein-protein interactions with molecular glues by Che, Ye, Gilbert, Adam M., Shanmugasundaram, Veerabahu, Noe, Mark C.

“…[Display omitted] •Molecular glues promote the unnatural association of proteins to produce a therapeutic effect.•Molecular glues alter the surface of proteins…”
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An Asymmetric Synthesis of (2S,5S)-5-Substituted Azepane-2-Carboxylate Derivatives by Wishka, Donn G, Bédard, Marion, Brighty, Katherine E, Buzon, Richard A, Farley, Kathleen A, Fichtner, Michael W, Kauffman, Goss S, Kooistra, Jaap, Lewis, Jason G, O’Dowd, Hardwin, Samardjiev, Ivan J, Samas, Brian, Yalamanchi, Geeta, Noe, Mark C

“…To facilitate a drug discovery project, we needed to develop a robust asymmetric synthesis of (2S,5S)-5-substituted-azepane-2-carboxylate derivatives. Two key…”
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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes by Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.

“…Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein…”
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Linezolid, the first oxazolidinone antibacterial agent by Leach, Karen L., Brickner, Steven J., Noe, Mark C., Miller, Paul F.

“…Linezolid (Zyvox™) is the first member of an entirely new class of antibiotics to reach the market in over 35 years; it was approved for use in 2000. A member…”
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A Critical Analysis of the Mechanistic Basis of Enantioselectivity in the Bis-Cinchona Alkaloid Catalyzed Dihydroxylation of Olefins by Corey, E. J, Noe, Mark C

“…This paper presents a critical analysis of two transition state models for the bis-cinchona alkaloid catalyzed enantioselective dihydroxylation of olefins…”
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Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry by DiRico, Kenneth J, Hua, Wenyi, Liu, Chang, Tucker, Joseph W, Ratnayake, Anokha S, Flanagan, Mark E, Troutman, Matthew D, Noe, Mark C, Zhang, Hui

“…High-throughput experimentation (HTE) has emerged as an important tool in drug discovery, providing a platform for preparing large compound libraries and…”
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The application of a mechanistic model leads to the extension of the Sharpless asymmetric dihydroxylation to allylic 4-methoxybenzoates and conformationally related amine and homoallylic alcohol derivatives by Corey, E. J, Guzman-Perez, Angel, Noe, Mark C

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Pyridone Methylsulfone Hydroxamate LpxC Inhibitors for the Treatment of Serious Gram-Negative Infections by Montgomery, Justin I, Brown, Matthew F, Reilly, Usa, Price, Loren M, Abramite, Joseph A, Arcari, Joel, Barham, Rose, Che, Ye, Chen, Jinshan Michael, Chung, Seung Won, Collantes, Elizabeth M, Desbonnet, Charlene, Doroski, Matthew, Doty, Jonathan, Engtrakul, Juntyma J, Harris, Thomas M, Huband, Michael, Knafels, John D, Leach, Karen L, Liu, Shenping, Marfat, Anthony, McAllister, Laura, McElroy, Eric, Menard, Carol A, Mitton-Fry, Mark, Mullins, Lisa, Noe, Mark C, O’Donnell, John, Oliver, Robert, Penzien, Joseph, Plummer, Mark, Shanmugasundaram, Veerabahu, Thoma, Christy, Tomaras, Andrew P, Uccello, Daniel P, Vaz, Alfin, Wishka, Donn G

“…The synthesis and biological activity of a new series of LpxC inhibitors represented by pyridone methylsulfone hydroxamate 2a is presented. Members of this…”
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Catalytic Diastereoselective Synthesis of Cis-1,2-Disubstituted Cyclopropanols from Esters Using a Vicinal Dicarbanion Equivalent by Corey, E. J, Rao, S. Achyutha, Noe, Mark C

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Pyridone-Conjugated Monobactam Antibiotics with Gram-Negative Activity by Brown, Matthew F, Mitton-Fry, Mark J, Arcari, Joel T, Barham, Rose, Casavant, Jeffrey, Gerstenberger, Brian S, Han, Seungil, Hardink, Joel R, Harris, Thomas M, Hoang, Thuy, Huband, Michael D, Lall, Manjinder S, Lemmon, M. Megan, Li, Chao, Lin, Jian, McCurdy, Sandra P, McElroy, Eric, McPherson, Craig, Marr, Eric S, Mueller, John P, Mullins, Lisa, Nikitenko, Antonia A, Noe, Mark C, Penzien, Joseph, Plummer, Mark S, Schuff, Brandon P, Shanmugasundaram, Veerabahu, Starr, Jeremy T, Sun, Jianmin, Tomaras, Andrew, Young, Jennifer A, Zaniewski, Richard P

“…Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity…”
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Rigid and highly enantioselective catalyst for the dihydroxylation of olefins using osmium tetraoxide clarifies the origin of enantiospecificity by Corey, E. J, Noe, Mark C

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Short Enantioselective Synthesis of (-)-Ovalicin, a Potent Inhibitor of Angiogenesis, Using Substrate-Enhanced Catalytic Asymmetric Dihydroxylation by Corey, E. J, Guzman-Perez, Angel, Noe, Mark C

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Discovery of Dap‑3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections by Magee, Thomas V, Brown, Matthew F, Starr, Jeremy T, Ackley, David C, Abramite, Joseph A, Aubrecht, Jiri, Butler, Andrew, Crandon, Jared L, Dib-Hajj, Fadia, Flanagan, Mark E, Granskog, Karl, Hardink, Joel R, Huband, Michael D, Irvine, Rebecca, Kuhn, Michael, Leach, Karen L, Li, Bryan, Lin, Jian, Luke, David R, MacVane, Shawn H, Miller, Alita A, McCurdy, Sandra, McKim, James M, Nicolau, David P, Nguyen, Thuy-Trinh, Noe, Mark C, O’Donnell, John P, Seibel, Scott B, Shen, Yue, Stepan, Antonia F, Tomaras, Andrew P, Wilga, Paul C, Zhang, Li, Xu, Jinfeng, Chen, Jinshan Michael

“…We report novel polymyxin analogues with improved antibacterial in vitro potency against polymyxin resistant recent clinical isolates of Acinetobacter…”
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The origin of greater than 200:1 enantioselectivity in a catalytic Diels-Alder reaction as revealed by physical and chemical studies by Corey, E. J, Loh, Teck Peng, Roper, Thomas D, Azimioara, Mihai D, Noe, Mark C

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X-ray Crystal and NMR Structure of a Highly Reactive Bidentate 1,2-Diamine−OsO4 Complex, Formally a 20-Electron Outer Valence Shell Species. Mechanistic Implications for the 1,2-Diamine-Accelerated Dihydroxylation of Olefins by OsO4 by Corey, E. J, Sarshar, Sepehr, Azimioara, Mihai D, Newbold, Ronald C, Noe, Mark C

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