Search Results - "Nodwell, Matthew B."

Site‐Selective, Late‐Stage C−H 18F‐Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging by Yuan, Zheliang, Nodwell, Matthew B., Yang, Hua, Malik, Noeen, Merkens, Helen, Bénard, François, Martin, Rainer E., Schaffer, Paul, Britton, Robert

“…Peptides are often ideal ligands for diagnostic molecular imaging due to their ease of synthesis and tuneable targeting properties. However, labelling…”
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A Convenient Late-Stage Fluorination of Pyridylic C−H Bonds with N-Fluorobenzenesulfonimide by Meanwell, Michael, Nodwell, Matthew B., Martin, Rainer E., Britton, Robert

“…Pyridine features prominently in pharmaceuticals and drug leads, and methods to selectively manipulate pyridine basicity or metabolic stability are highly…”
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Direct photocatalytic fluorination of benzylic C-H bonds with N-fluorobenzenesulfonimide by Nodwell, Matthew B, Bagai, Abhimanyu, Halperin, Shira D, Martin, Rainer E, Knust, Henner, Britton, Robert

“…The late-stage fluorination of common synthetic building blocks and drug leads is an appealing reaction for medicinal chemistry. In particular, fluorination of…”
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Site‐Selective, Late‐Stage C−H 18F‐Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging by Yuan, Zheliang, Nodwell, Matthew B., Yang, Hua, Malik, Noeen, Merkens, Helen, Bénard, François, Martin, Rainer E., Schaffer, Paul, Britton, Robert

“…Peptides are often ideal ligands for diagnostic molecular imaging due to their ease of synthesis and tuneable targeting properties. However, labelling…”
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Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics by Hoegl, Annabelle, Nodwell, Matthew B., Kirsch, Volker C., Bach, Nina C., Pfanzelt, Martin, Stahl, Matthias, Schneider, Sabine, Sieber, Stephan A.

“…Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation of biological amines in many central cellular processes. PLP-dependent…”
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A Convenient Synthesis of Difluoroalkyl Ethers from Thionoesters Using Silver(I) Fluoride by Newton, Josiah, Driedger, Daniel, Nodwell, Matthew B., Schaffer, Paul, Martin, Rainer E., Britton, Robert, Friesen, Chadron M.

“…Herein we report the mild and rapid fluorodesulfurization of thionoesters using only silver(I) fluoride. This reaction demonstrates excellent functional group…”
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A Chemical Proteomic Analysis of Illudin‐Interacting Proteins by Le, Philipp, Nodwell, Matthew B., Eirich, Jürgen, Sieber, Stephan A.

“…The illudin natural product family are fungal secondary metabolites with a characteristic spirocyclopropyl‐substituted fused 6,5‐bicyclic ring system. They…”
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Practical and concise synthesis of nucleoside analogs by Davison, Emma K., Petrone, David A., Meanwell, Michael, Nodwell, Matthew B., Silverman, Steven M., Campeau, Louis-Charles, Britton, Robert

“…Nucleoside analogs are valuable commodities in the development of antisense oligonucleotides or as stand-alone antiviral and anticancer therapies. Syntheses of…”
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Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives by Meanwell, Michael, Adluri, Bharani Shashank, Yuan, Zheliang, Newton, Josiah, Prevost, Philippe, Nodwell, Matthew B, Friesen, Chadron M, Schaffer, Paul, Martin, Rainer E, Britton, Robert

“…Functionalization of heterocyclic scaffolds with mono- or difluoroalkyl groups provides unique opportunities to modulate drug p , influence potency and…”
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Enterobactin on a Bead: Parallel, Solid Phase Siderophore Synthesis Reveals Structure-Activity Relationships for Iron Uptake in Bacteria by Nodwell, Matthew B, Britton, Robert

“…A solid-phase platform for the precise and sequential synthesis of enterobactin analogues is described. This chemistry unites the power of solid-phase peptide…”
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Exploring the Positional Attachment of Glycopeptide/β-lactam Heterodimers by Long, Daniel D, Aggen, James B, Chinn, Jason, Choi, Seok-Ki, Christensen, Burton G, Fatheree, Paul R, Green, David, Hegde, Sharath S, Judice, J Kevin, Kaniga, Koné, Krause, Kevin M, Leadbetter, Michael, Linsell, Martin S, Marquess, Daniel G, Moran, Edmund J, Nodwell, Matthew B, Pace, John L, Trapp, Sean G, Turne, S Derek

“…Further investigations towards novel glycopeptide/β-lactam heterodimers are reported. Employing a multivalent approach to drug discovery, vancomycin and…”
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Rapid 18F‐ and 19F‐Difluoromethylation through Desulfurative Fluorination of Transient N‐, O‐, and C‐Linked Dithioles by Newton, Josiah J., Engüdar, Gökçe, Brooke, Alan J., Nodwell, Matthew B., Horngren‐Rhodes, Holly, Martin, Rainer E., Schaffer, Paul, Britton, Robert, Friesen, Chadron M.

“…The difluoromethyl group plays an important role in modern medicinal and agrochemistry. While several difluoromethylation reagents have been reported, these…”
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Rapid 18 F- and 19 F-Difluoromethylation through Desulfurative Fluorination of Transient N-, O-, and C-Linked Dithioles by Newton, Josiah J, Engüdar, Gökçe, Brooke, Alan J, Nodwell, Matthew B, Horngren-Rhodes, Holly, Martin, Rainer E, Schaffer, Paul, Britton, Robert, Friesen, Chadron M

“…The difluoromethyl group plays an important role in modern medicinal and agrochemistry. While several difluoromethylation reagents have been reported, these…”
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18 F-Branched-Chain Amino Acids: Structure-Activity Relationships and PET Imaging Potential by Nodwell, Matthew B, Yang, Hua, Merkens, Helen, Malik, Noeen, Čolović, Milena, Björn Wagner, Martin, Rainer E, Bénard, François, Schaffer, Paul, Britton, Robert

“…The large, neutral L-type amino acid transporters (LAT1-LAT4) are sodium-independent transporters that are widely distributed throughout the body. LAT…”
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Site-Selective, Late-Stage C-H 18 F-Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging by Yuan, Zheliang, Nodwell, Matthew B, Yang, Hua, Malik, Noeen, Merkens, Helen, Bénard, François, Martin, Rainer E, Schaffer, Paul, Britton, Robert

“…Peptides are often ideal ligands for diagnostic molecular imaging due to their ease of synthesis and tuneable targeting properties. However, labelling…”
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Efficient protocol for the preparation of α-heteroaryl acetaldehydes by Huxley, Cohan, Lucas, Callum, Bruno, Juan Manuel Mesa, Anketell, Matthew J., Davison, Emma K., Muir, Garrett, Nodwell, Matthew B., Meanwell, Michael, Silverman, Steven M., Britton, Robert, Campeau, Louis-Charles

“…α-heteroaryl acetaldehydes have become important building blocks in the synthesis of synthetic nucleosides. Novel organocatalytic cascades have enabled the…”
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Efficient protocol for the preparation of [alpha]-heteroaryl acetaldehydes by Huxley, Cohan, Lucas, Callum, Bruno, Juan Manuel Mesa, Anketell, Matthew J, Davison, Emma K, Muir, Garrett, Nodwell, Matthew B, Meanwell, Michael, Silverman, Steven M, Britton, Robert, Campeau, Louis-Charles

“…[alpha]-heteroaryl acetaldehydes have become important building blocks in the synthesis of synthetic nucleosides. Novel organocatalytic cascades have enabled…”
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18F-Branched-Chain Amino Acids: Structure–Activity Relationships and PET Imaging Potential by Nodwell, Matthew B, Yang, Hua, Merkens, Helen, Malik, Noeen, Čolović, Milena, Wagner, Björn, Martin, Rainer E, Bénard, François, Schaffer, Paul, Britton, Robert

“…The large, neutral L-type amino acid transporters (LAT1–LAT4) are sodium-independent transporters that are widely distributed throughout the body. LAT…”
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A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage by Nodwell, Matthew B, Koch, Maximilian F, Alte, Ferdinand, Schneider, Sabine, Sieber, Stephan A

“…Pyridoxal 5′-phosphate (PLP) is the active vitamer of vitamin B6 and acts as an essential cofactor in many aspects of amino acid and sugar metabolism. The…”
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18 F-Fluorination of Unactivated C-H Bonds in Branched Aliphatic Amino Acids: Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents by Nodwell, Matthew B, Yang, Hua, Čolović, Milena, Yuan, Zheliang, Merkens, Helen, Martin, Rainer E, Bénard, François, Schaffer, Paul, Britton, Robert

“…A mild and selective photocatalytic C-H F-fluorination reaction has been developed that provides direct access to F-fluorinated amino acids. The…”
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