Search Results - "Noch, Evan"

Challenges in the Treatment of Glioblastoma: Multisystem Mechanisms of Therapeutic Resistance by Noch, Evan K., Ramakrishna, Rohan, Magge, Rajiv

“…Glioblastoma is one of the most lethal human cancers, with poor survival despite surgery, radiation treatment, and chemotherapy. Advances in the treatment of…”
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Right Brain: Home is where the heart is by Noch, Evan K

“…Home. Few 4-letter words can be more haunting, and at times, more impossible, to a physician. "I want to go home." These were the words that were on 3-second…”
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Oncogenic viruses and tumor glucose metabolism: like kids in a candy store by Noch, Evan, Khalili, Kamel

“…Oncogenic viruses represent a significant public health burden in light of the multitude of malignancies that result from chronic or spontaneous viral…”
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Molecular mechanisms of necrosis in glioblastoma: The role of glutamate excitotoxicity by Noch, Evan, Khalili, Kamel

“…Glioblastomas continue to rank among the most lethal primary human tumors.  Despite treatment with the most rigorous surgical interventions along with the most…”
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Metabolic partitioning in the brain and its hijacking by glioblastoma by de Ruiter Swain, Jed, Michalopoulou, Evdokia, Noch, Evan K, Lukey, Michael J, Van Aelst, Linda

“…The different cell types in the brain have highly specialized roles with unique metabolic requirements. Normal brain function requires the coordinated…”
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Distribution and localization of phosphatidylinositol 5‐phosphate, 4‐kinase alpha and beta in the brain by Noch, Evan K., Yim, Isaiah, Milner, Teresa A., Cantley, Lewis C.

“…Phosphatidylinositol‐4,5‐bisphosphate (PI‐4,5‐P2) is critical for synaptic vesicle docking and fusion and generation of the second messengers, diacylglycerol…”
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The Role of AEG-1/MTDH/LYRIC in the Pathogenesis of Central Nervous System Disease by Noch, Evan K., Khalili, Kamel

“…Astrocyte-elevated gene-1 (AEG-1/MTDH/LYRIC) is a potent oncogene that regulates key cellular processes underlying disease of the central nervous system (CNS)…”
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Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production by Noch, Evan K, Palma, Laura, Yim, Isaiah, Bullen, Nayah, Barnett, Daniel, Walsh, Alexander, Bhinder, Bhavneet, Benedetti, Elisa, Krumsiek, Jan, Gurvitch, Justin, Khwaja, Sumaiyah, Atlas, Daphne, Elemento, Olivier, Cantley, Lewis C

“…Glucose and amino acid metabolism are critical for glioblastoma (GBM) growth, but little is known about the specific metabolic alterations in GBM that are…”
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Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma by Noch, Evan K, Palma, Laura N, Yim, Isaiah, Bullen, Nayah, Qiu, Yuqing, Ravichandran, Hiranmayi, Kim, Junbum, Rendeiro, Andre, Davis, Melissa B, Elemento, Olivier, Pisapia, David J, Zhai, Kevin, LeKaye, Hongbiao Carl, Koutcher, Jason A, Wen, Patrick Y, Ligon, Keith L, Cantley, Lewis C

“…Abstract Background Insulin feedback is a critical mechanism responsible for the poor clinical efficacy of phosphatidylinositol 3-kinase (PI3K) inhibition in…”
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A case series of extraneural metastatic glioblastoma at Memorial Sloan Kettering Cancer Center by Noch, Evan K, Sait, Sameer F, Farooq, Shama, Trippett, Tanya M, Miller, Alexandra M

“…Abstract Background Extraneural metastasis of glioma is a rare event, often occurring in patients with advanced disease. Genomic alterations associated with…”
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Human MicroRNA Genes Are Frequently Located at Fragile Sites and Genomic Regions Involved in Cancers by Calin, George Adrian, Sevignani, Cinzia, Dumitru, Calin Dan, Hyslop, Terry, Noch, Evan, Yendamuri, Sai, Shimizu, Masayoshi, Rattan, Sashi, Bullrich, Florencia, Negrini, Massimo, Croce, Carlo M.

“…A large number of tiny noncoding RNAs have been cloned and named microRNAs (miRs). Recently, we have reported that miR-15a and miR-16a, located at 13q14, are…”
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Frequent Deletions and Down-Regulation of Micro-RNA Genes miR15 and miR16 at 13q14 in Chronic Lymphocytic Leukemia by Calin, George Adrian, Dumitru, Calin Dan, Shimizu, Masayoshi, Bichi, Roberta, Zupo, Simona, Noch, Evan, Aldler, Hansjuerg, Rattan, Sashi, Keating, Michael, Rai, Kanti, Rassenti, Laura, Kipps, Thomas, Negrini, Massimo, Bullrich, Florencia, Croce, Carlo M.

“…Micro-RNAs (miR genes) are a large family of highly conserved noncoding genes thought to be involved in temporal and tissue-specific gene regulation. MiRs are…”
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Qualitative feasibility study of the mobile app Destroke for clinical stroke monitoring based on the NIH stroke scale by Noch, Evan K., Pham, Dan, Kitago, Tomoko, Wuennemann, Marissa, Wortman-Jutt, Susan, Falo, M. Cristina

“…Stroke is a leading cause of severe disability in the United States, but there is no effective method for patients to accurately detect the signs of stroke at…”
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Impact of COVID-19 pandemic on physician-scientist trainees to faculty one year into the pandemic by Obradovic, Aleksandar, Toubat, Omar, Chen, Nathan W, Siebert, Aisha, Jansen, Caroline, Christophers, Briana, Leveille, Etienne, Noch, Evan, Kwan, Jennifer M

“…Physician-scientists play a crucial role in advancing biomedical sciences. Proportionally fewer physicians are actively engaged in scientific pursuits,…”
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Astrocyte-elevated gene-1 (AEG-1) induction by hypoxia and glucose deprivation in glioblastoma by Noch, Evan, Bookland, Markus, Khalili, Kamel

“…Glioblastomas continue to carry poor prognoses for patients despite advances in surgical, chemotherapeutic, and radiation regimens. One feature of glioblastoma…”
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JC virus T-antigen regulates glucose metabolic pathways in brain tumor cells by Noch, Evan, Sariyer, Ilker Kudret, Gordon, Jennifer, Khalili, Kamel

“…Recent studies have reported the detection of the human neurotropic virus, JCV, in a significant population of brain tumors, including medulloblastomas…”
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A closer look at attrition in MD–PhD programs by Mittwede, Peter N, Noch, Evan K, Guo, Michael H

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Abstract 2062: Evaluating the effect of tumor necrosis on glycolytic flux and cell survival in glioblastoma by Noch, Evan, Yim, Isaiah, Cantley, Lewis

“…Abstract Glioblastoma continues to rank as one of the most lethal primary human tumors. The degree of necrosis in glioblastoma remains one of the most powerful…”
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A case series of metastatic glioblastoma at Memorial Sloan Kettering Cancer Center (P1.6-008) by Noch, Evan, Sait, Sameer Farouk, Miller, Alexandra

“…Abstract only…”
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EXTH-36. PI3K INHIBITION IN CONJUNCTION WITH THE KETOGENIC DIET REDUCES GROWTH AND NEUROINFLAMMATION IN PEDIATRIC HIGH-GRADE GLIOMA by Noch, Evan, Yim, Isaiah, Cantley, Lewis

“…Abstract Pediatric high-grade glioma remains a poorly treatable disease with high mortality. Targeted therapies have gained interest in this disease, but…”
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