Search Results - "Nobukuni, Y"

Analyses of loss-of-function mutations of the MITF gene suggest that haploinsufficiency is a cause of Waardenburg syndrome type 2A by Nobukuni, Y, Watanabe, A, Takeda, K, Skarka, H, Tachibana, M

“…Waardenburg syndrome type 2 (WS2) is a dominantly inherited disorder characterized by a pigmentation anomaly and hearing impairment due to lack of melanocyte…”
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Experimental Exploration for Genes Related to Susceptibility and Resistance to Irinotecan by Ogata, Suguru, Sudou, Tomoya, Fujita, Fumihiko, Yoshida, Takefumi, Koushi, Kenichi, Noguchi, Takashi, Fukuda, Junya, Ogata, Nanae, Nobukuni, Yoshitaka, Akagi, Yoshito

“…Background/Aim: Anticancer drug resistance is an important issue in cancer treatment. Multiple genes are thought to be involved in resistance to anticancer…”
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A late-appearing Philadelphia chromosome in acute lymphoblastic leukemia confirmed by expression of BCR-ABL mRNA by Tsuchiya, H, Migita, M, Yamamori, S, Kaneko, Y, Adachi, N, Nakamura, T, Nobukuni, Y, el-Sonbaty, S S, Matsuda, I

“…We report two cases of acute lymphoblastic leukemia (ALL) with a late-appearing Philadelphia chromosome (Ph1), confirmed by the expression of BCR-ABL mRNA,…”
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Structural organization and chromosomal localization of the gene for the E1 beta subunit of human branched chain alpha-keto acid dehydrogenase by MITSUBUCHI, H, NOBUKUNI, Y, ENDO, F, MATSUDA, I

“…A defect in the E1 beta subunit of the branched chain alpha-keto acid dehydrogenase (BCKDH) complex is one cause of maple syrup urine disease (MSUD). In an…”
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Assignment of the gene for a ubiquitin-conjugating enzyme (UBE2I) to human chromosome band 16p13.3 by in situ hybridization by Tachibana, M, Iwata, N, Watanabe, A, Nobukuni, Y, Ploplis, B, Kajigaya, S

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Gene analysis of mennonite maple syrup urine disease kindred using primer‐specified restriction map modification by Mitsubuchi, H., Matsuda, I., Nobukuni, Y., Heidenreich, R., Indo, Y., Endo, F., Mallee, J., Segal, S.

“…Summary Maple syrup urine disease (MSUD) is an autosomal recessive inherited disease due to a deficiency of any of the subunits, E1α, E1β or E2, of the…”
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Molecular diagnosis of maple syrup urine disease: Screening and identification of gene mutations in the branched‐chain α‐ketoacid dehydrogenase multienzyme complex by Nobukuni, Y., Mitsubuchi, H., Ohta, K., Akaboshi, I., Indo, Y., Endo, F., Matsuda, I.

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Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L by MAOKA, Takashi, MOCHIDA, Kooich, NISHINO, Hoyoku, KOZUKA, Mutsuo, ITO, Yoshihiro, FUJIWARA, Yasuhiro, HASHIMOTO, Keiji, ENJO, Fumio, OGATA, Masakazu, NOBUKUNI, Yoshitoshi, TOKUDA, Harukuni

“…Capsanthin and related carotenoids isolated from the fruits of red paprika Capsicum annuum L. showed potent in vitro anti-tumor-promoting activity with…”
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Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance by TAKEDA, K, TAKEMOTO, C, KOBAYASHI, I, WATANABE, A, NOBUKUNI, Y, FISHER, D. E, TACHIBANA, M

“…MITF (microphthalmia-associated transcription factor) is a basic-helix-loop-helix-leucine zipper (bHLHZip) factor which regulates expression of tyrosinase and…”
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Maple syrup urine disease: Clinical and biochemical significance of gene analysis by Nobukuni, Y., Mitsubuchi, H., Akaboshi, I., Indo, Y., Endo, F., Matsuda, I.

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Gene Trap Mutagenesis-based Forward Genetic Approach Reveals That the Tumor Suppressor OVCA1 Is a Component of the Biosynthetic Pathway of Diphthamide on Elongation Factor 2 by Nobukuni, Yoshitaka, Kohno, Kenji, Miyagawa, Kiyoshi

“…OVCA1 is a tumor suppressor identified by positional cloning from chromosome 17p13.3, a hot spot for chromosomal aberration in breast and ovarian cancers. It…”
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Inhibition of Tumor-Promoting Effects by Poricoic Acids G and H and Other Lanostane-Type Triterpenes and Cytotoxic Activity of Poricoic Acids A and G from Poria cocos by Ukiya, Motohiko, Akihisa, Toshihiro, Tokuda, Harukuni, Hirano, Masaya, Oshikubo, Manabu, Nobukuni, Yoshitoshi, Kimura, Yumiko, Tai, Takaaki, Kondo, Seizo, Nishino, Hoyoku

“…The structures of two novel 3,4-seco-lanostane-type triterpenes isolated from the sclerotium of Poria cocos were established to be…”
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Cancer chemopreventive activity of Achyranthes aspera leaves on Epstein–Barr virus activation and two-stage mouse skin carcinogenesis by Chakraborty, Asima, Brantner, Adelheid, Mukainaka, Teruo, Nobukuni, Yoshitoshi, Kuchide, Masashi, Konoshima, Takao, Tokuda, Harukuni, Nishino, Hoyoku

“…Achyranthes aspera leaves have been assessed for chemopreventive activity. The MeOH extract, alkaloid, non-alkaloid and saponin fractions exhibited significant…”
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Ectopic expression of MITF , a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics by Aaronson, Stuart A, Meyers, Kimberly A, Miki, Toru, Long, Jason E, Tachibana, Masayoshi, Nobukuni, Yoshitaka, Takeda, Kazuhisa, Urabe, Kazunori

“…MITF (microphthalmia-associated transcription factor) encodes a transcription factor with a basic-helix-loop-helix-zipper (bHLH-Zip) motif. MITF mutations…”
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Interiotherins C and D, Two New Lignans from Kadsura interior and Antitumor-Promoting Effects of Related Neolignans on Epstein−Barr Virus Activation by CHEN, Dao-Feng, ZHANG, Shun-Xiang, KOZUKA, Mutsuo, SUN, Quan-Zhong, FENG, Ju, WANG, Qiang, MUKAINAKA, Teruo, NOBUKUNI, Yoshitaka, TOKUDA, Harukuni, NISHINO, Hoyoku, WANG, Hui-Kang, MORRIS-NATSCHKE, Susan L., LEE, Kuo-Hsiung

“…Two new lignans, interiotherins C (1) and D (2), together with the known compounds interiorin (3), heteroclitin F (4), neokadsuranin (5), heteroclitin D (6),…”
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Nonthermal effects of mobile-phone frequency microwaves on uteroplacental functions in pregnant rats by Nakamura, Hiroyuki, Matsuzaki, Ichiyo, Hatta, Kotaro, Nobukuni, Yoshitaka, Kambayashi, Yasuhiro, Ogino, Keiki

“…Exposure to high-density microwaves can cause detrimental effects on the testis, eye, and other tissues, and induce significant biologic changes through…”
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Maple syrup urine disease: molecular pathology of the branched chain alpha-keto acid dehydrogenase complex by Nobukuni, Y, Mitsubuchi, H, Indo, Y, Endo, F, Matsuda, I

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Gene analysis of maple syrup urine disease (MSUD) by Mitsubuchi, H, Nobukuni, Y, Hayashida, Y, Ohta, K, Indo, Y, Akaboshi, I, Endo, F, Matsuda, I

“…Maple syrup urine disease (MSUD), an autosomal recessive hereditary metabolic disorder, is due to defective oxidative decarboxylation of the branched-chain…”
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Chemopreventive effects of emodin and cassiamin B in mouse skin carcinogenesis by Koyama, Junko, Morita, Izumi, Tagahara, Kiyoshi, Nobukuni, Yoshitaka, Mukainaka, Teruo, Kuchide, Masashi, Tokuda, Harukuni, Nishino, Hoyoku

“…In continuation of our works of natural and synthetic products as cancer chemopreventive agents, we have examined emodin and cassiamin B, which were isolated…”
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Interorgan metabolism of glutathione as the defence mechanism against oxidative stress by Inoue, M, Nobukuni, Y, Ando, Y, Hirota, M, Hirata, E, Morino, Y

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