Search Results - "Nobuchika Suzuki"

Gα12 Activates Rho GTPase through Tyrosine-Phosphorylated Leukemia-Associated RhoGEF by Suzuki, Nobuchika, Nakamura, Susumu, Mano, Hiroyuki, Kozasa, Tohru

“…Heterotrimeric G proteins, G12 and G13, have been shown to transduce signals from G protein-coupled receptors to activate Rho GTPase in cells. Recently, we…”
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Regulation and Physiological Functions of G12/13-Mediated Signaling Pathways by Suzuki, Nobuchika, Hajicek, Nicole, Kozasa, Tohru

“…Accumulating data indicate that G12 subfamily (Gα12/13)-mediated signaling pathways play pivotal roles in a variety of physiological processes, while aberrant…”
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Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration by Patel, Maulik, Kawano, Takeharu, Suzuki, Nobuchika, Hamakubo, Takao, Karginov, Andrei V, Kozasa, Tohru

“…Gastrin-releasing peptide receptor (GRPR) is ectopically expressed in over 60% of colon cancers. GRPR expression has been correlated with increased colon…”
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Targeting gene expression to specific cells of kidney tubules in vivo, using adenoviral promoter fragments by Watanabe, Sumiyo, Ogasawara, Toru, Tamura, Yoshifuru, Saito, Taku, Ikeda, Toshiyuki, Suzuki, Nobuchika, Shimosawa, Tatsuo, Shibata, Shigeru, Chung, Ung-Il, Nangaku, Masaomi, Uchida, Shunya

“…Although techniques for cell-specific gene expression via viral transfer have advanced, many challenges (e.g., viral vector design, transduction of genes into…”
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Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13 by Kozasa, Tohru, Hajicek, Nicole, Chow, Christina R., Suzuki, Nobuchika

“…G protein-mediated signal transduction can transduce signals from a large variety of extracellular stimuli into cells and is the most widely used mechanism for…”
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Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1 by Helms, Michelle C., Grabocka, Elda, Martz, Matthew K., Fischer, Christopher C., Suzuki, Nobuchika, Wedegaertner, Philip B.

“…Rho GTPases are integral to the regulation of actin cytoskeleton-dependent processes, including mitosis. Rho and leukemia-associated Rho guanine-nucleotide…”
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G protein–dependent basal and evoked endothelial cell vWF secretion by Rusu, Luiza, Andreeva, Alexandra, Visintine, David J., Kim, Kyungho, Vogel, Stephen M., Stojanovic-Terpo, Aleksandra, Chernaya, Olga, Liu, Guoquan, Bakhshi, Farnaz R., Haberichter, Sandra L., Iwanari, Hiroko, Kusano-Arai, Osamu, Suzuki, Nobuchika, Hamakubo, Takao, Kozasa, Tohru, Cho, Jaehyung, Du, Xiaoping, Minshall, Richard D.

“…von Willebrand factor (vWF) secretion by endothelial cells (ECs) is essential for hemostasis and thrombosis; however, the molecular mechanisms are poorly…”
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Modification of p115RhoGEF Ser330 regulates its RhoGEF activity by Chow, Christina R., Suzuki, Nobuchika, Kawamura, Takeshi, Hamakubo, Takao, Kozasa, Tohru

“…p115RhoGEF is a member of a family of Rho-specific guanine nucleotide exchange factors that also contains a regulator of G protein signaling homology domain…”
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The Small GTPase RalA Targets Filamin to Induce Filopodia by Ohta, Yasutaka, Suzuki, Nobuchika, Nakamura, Shun, Hartwig, John H., Stossel, Thomas P.

“…The Ras-related small GTPases Rac, Rho, Cdc42, and RalA bind filamin, an actin filament-crosslinking protein that also links membrane and other intracellular…”
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Involvement of IGF-1/LARG Signaling in the Differentiation of Neural Stem Cells into Oligodendrocytes by Suzuki, Nobuchika, Tokita, Reiko, Minami, Shiro

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Growth Hormone Inhibits Its Own Secretion by Acting on the Hypothalamus through Its Receptors on Neuropeptide Y Neurons in the Arcuate Nucleus and Somatostatin Neurons in the Periventricular Nucleus by MINAMI, SHIRO, KAMEGAI, JUN, SUGIHARA, HITOSHI, SUZUKI, NOBUCHIKA, WAKABAYASHI, ICHIJI

“…GH secretion is regulated by hypothalamic somatostatin and GH-releasing factor. It has been postulated that GH feeds back on the hypothalamus and regulates its…”
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Cdk1‐dependent phosphorylation of leukemia‐associated RhoGEF during mitosis (802.30) by Helms, Michelle, Grabocka, Elda, Martz, Matthew, Suzuki, Nobuchika, Wedegaertner, Philip

“…Rho GTPases are crucial players in the regulation of actin cytoskeleton‐dependent processes such as mitosis. Our laboratory has discovered a novel role and…”
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Involvement of IGF-1/LARG Signaling in the Differentiation of Neural Stem Cells into Oligodendrocytes by Nobuchika Suzuki, Reiko Tokita, Shiro Minami

“…Neural stem cells can differentiate into neurons, astrocytes, and oligodendrocytes in the mammalian central nervous system, but the molecular mechanisms that…”
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Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity by Chow, Christina R, Suzuki, Nobuchika, Kawamura, Takeshi, Hamakubo, Takao, Kozasa, Tohru

“…p115RhoGEF is a member of a family of Rho-specific guanine nucleotide exchange factors that also contains a regulator of G protein signaling homology domain…”
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Central glucoprivation evoked by administration of 2-deoxy- d-glucose induces expression of the c- fos gene in a subpopulation of neuropeptide Y neurons in the rat hypothalamus by Minami, Shiro, Kamegai, Jun, Sugihara, Hitoshi, Suzuki, Nobuchika, Higuchi, Hiroshi, Wakabayashi, Ichiji

“…Central glucoprivation evoked by the intracerebroventricular administration of 2-deoxy- d-glucose (2DG) induces eating and suppresses growth hormone (GH)…”
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Activation of Leukemia-associated RhoGEF by Gα13 with Significant Conformational Rearrangements in the Interface by Suzuki, Nobuchika, Tsumoto, Kouhei, Hajicek, Nicole, Daigo, Kenji, Tokita, Reiko, Minami, Shiro, Kodama, Tatsuhiko, Hamakubo, Takao, Kozasa, Tohru

“…The transient protein-protein interactions induced by guanine nucleotide-dependent conformational changes of G proteins play central roles in G protein-coupled…”
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A method of generating antibodies against exogenously administered self-antigen by manipulating CD4 +CD25 + regulatory T cells by Iwanari, Hiroko, Nakada-Nakura, Yoshiko, Kusano-Arai, Osamu, Suzuki, Nobuchika, Kodama, Tatsuhiko, Sakihama, Toshiko, Hamakubo, Takao

“…The generation of antibodies against self-antigens or antigens having a high degree of structural homology with self-antigens is a difficult task because of…”
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Activation of Leukemia-associated RhoGEF by Gα13 with Significant Conformational Rearrangements in the InterfaceS by Suzuki, Nobuchika, Tsumoto, Kouhei, Hajicek, Nicole, Daigo, Kenji, Tokita, Reiko, Minami, Shiro, Kodama, Tatsuhiko, Hamakubo, Takao, Kozasa, Tohru

“…The transient protein-protein interactions induced by guanine nucleotide-dependent conformational changes of G proteins play central roles in G protein-coupled…”
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Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface by Suzuki, Nobuchika, Tsumoto, Kouhei, Hajicek, Nicole, Daigo, Kenji, Tokita, Reiko, Minami, Shiro, Kodama, Tatsuhiko, Hamakubo, Takao, Kozasa, Tohru

“…The transient protein-protein interactions induced by guanine nucleotide-dependent conformational changes of G proteins play central roles in G protein-coupled…”
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Activation of Leukemia-associated RhoGEF by G{alpha}13 with Significant Conformational Rearrangements in the Interface by Suzuki, Nobuchika, Tsumoto, Kouhei, Hajicek, Nicole, Daigo, Kenji, Tokita, Reiko, Minami, Shiro, Kodama, Tatsuhiko, Hamakubo, Takao, Kozasa, Tohru

“…The transient protein-protein interactions induced by guanine nucleotide-dependent conformational changes of G proteins play central roles in G protein-coupled…”
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