Breast Adiposity: Menopausal Status Impact and its Influence on Glycemic and Anthropometric Metabolic Parameters

Abstract Context Ectopic fat depots are related to the deregulation of energy homeostasis, leading to diseases related to obesity and metabolic syndrome (MetS). Despite significant changes in body composition over women's lifespans, little is known about the role of breast adipose tissue (BrAT)...

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Published in:	The journal of clinical endocrinology and metabolism Vol. 109; no. 10; pp. 2467 - 2477
Main Authors:	Limberger Nedel, Barbara, Garcia Madure, Michelle, Guaresi, Silvia, Soares Machado, Maria Elisa, Madrid de Bittencourt, Marcelo, Nobrega Chagas, Nathalia, Gerchman, Fernando
Format:	Journal Article
Language:	English
Published:	US Oxford University Press 16-09-2024
Subjects:	Adipose tissue Adipose Tissue - metabolism Adiposity - physiology Adult Anthropometry Biochemical analysis Blood Glucose - analysis Blood Glucose - metabolism Body composition Body Composition - physiology Body fat Body Mass Index Breast Breast - diagnostic imaging Breast - metabolism Cross-Sectional Studies Energy balance Fasting Female Hemoglobin Homeostasis Humans Hyperglycemia Insulin resistance Insulin Resistance - physiology Laboratory testing Menopause Menopause - blood Menopause - metabolism Menopause - physiology Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - metabolism Metabolism Middle Aged Post-menopause Premenopause Womens health metabolic homeostasis breast adipose tissue mammograms breast adiposity ectopic fat menopausal status
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Summary:	Abstract Context Ectopic fat depots are related to the deregulation of energy homeostasis, leading to diseases related to obesity and metabolic syndrome (MetS). Despite significant changes in body composition over women's lifespans, little is known about the role of breast adipose tissue (BrAT) and its possible utilization as an ectopic fat depot in women of different menopausal statuses. Objective We aimed to assess the relationship between BrAT and metabolic glycemic and lipid profiles and body composition parameters in adult women. Methods In this cross-sectional study, we enrolled adult women undergoing routine mammograms and performed history and physical examination, body composition assessment, semi-automated assessment of breast adiposity (BA) from mammograms, and fasting blood collection for biochemical analysis. Correlations and multivariate regression analysis were used to examine associations of BA with metabolic and body composition parameters. Results Of the 101 participants included in the final analysis, 76.2% were in menopause, and 23.8% were in premenopause. The BA was positively related with fasting plasma glucose, glycated hemoglobin, homeostasis model assessment of insulin resistance, body mass index, waist circumference, body fat percentage, and abdominal visceral and subcutaneous fat when adjusted for age among women in postmenopause. Also, the BA was an independent predictor of hyperglycemia and MetS. These associations were not present among women in premenopause. Conclusion The BA was related to different adverse body composition and metabolic factors in women in postmenopause. The results suggest that there might be a relevant BrAT endocrine role during menopause, with mechanisms yet to be clarified, thus opening up research perspectives on the subject and potential clinical implications.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-972X 1945-7197 1945-7197
DOI:	10.1210/clinem/dgae205