Search Results - "Nobre, Rui"

Science around the world by Griffiths, Meaghan J., Nobre, Rui J.

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Molecular therapy for polyQ disorders: from bench to clinical trials by de Sousa-Lourenço, João, Silva, Ana C., Pereira de Almeida, Luís, Nobre, Rui J.

“…Polyglutamine (polyQ) disorders are monogenic neurodegenerative disorders. Currently, no therapies are available for this complex group of disorders. Here, we…”
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Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads by Leandro, Kevin, Rufino-Ramos, David, Breyne, Koen, Di Ianni, Emilio, Lopes, Sara M., Jorge Nobre, Rui, Kleinstiver, Benjamin P., Perdigão, Pedro R.L., Breakefield, Xandra O., Pereira de Almeida, Luís

“…[Display omitted] Gene editing technologies have the potential to correct genetic disorders by modifying, inserting, or deleting specific DNA sequences or…”
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MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress by Rodrigues, Beatriz, Leitão, Ricardo A, Santos, Mónica, Trofimov, Alexander, Silva, Mariline, Inácio, Ângela S, Abreu, Mónica, Nobre, Rui J, Costa, Jéssica, Cardoso, Ana Luísa, Milosevic, Ira, Peça, João, Oliveiros, Bárbara, Pereira de Almeida, Luís, Pinheiro, Paulo S, Carvalho, Ana Luísa

“…Chronic stress exerts profound negative effects on cognitive and emotional behaviours and is a major risk factor for the development of neuropsychiatric…”
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Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment by Onofre, Isabel, Mendonça, Nuno, Lopes, Sara, Nobre, Rui, de Melo, Joana Barbosa, Carreira, Isabel Marques, Januário, Cristina, Gonçalves, António Freire, de Almeida, Luis Pereira

“…Machado Joseph Disease (MJD) is the most frequent autosomal dominantly inherited cerebellar ataxia caused by the over-repetition of a CAG trinucleotide in the…”
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Gene therapy for the CNS using AAVs: The impact of systemic delivery by AAV9 by Saraiva, Joana, Nobre, Rui Jorge, Pereira de Almeida, Luis

“…Several attempts have been made to discover the ideal vector for gene therapy in central nervous system (CNS). Adeno-associated viruses (AAVs) are currently…”
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Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy by Marcelo, Adriana, Afonso, Inês T., Afonso-Reis, Ricardo, Brito, David V. C., Costa, Rafael G., Rosa, Ana, Alves-Cruzeiro, João, Ferreira, Benedita, Henriques, Carina, Nobre, Rui J., Matos, Carlos A., de Almeida, Luís Pereira, Nóbrega, Clévio

“…Spinocerebellar ataxia type 2 (SCA2) is an incurable and genetic neurodegenerative disorder. The disease is characterized by progressive degeneration of…”
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Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death by Costa, João T., Mele, Miranda, Baptista, Márcio S., Gomes, João R., Ruscher, Karsten, Nobre, Rui J., de Almeida, Luís Pereira, Wieloch, Tadeusz, Duarte, Carlos B.

“…GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous system, and changes in GABAergic neurotransmission modulate the…”
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Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders by Silva, Ana C, Lobo, Diana D, Martins, Inês M, Lopes, Sara M, Henriques, Carina, Duarte, Sónia P, Dodart, Jean-Cosme, Nobre, Rui Jorge, Pereira de Almeida, Luis

“…Polyglutamine (polyQ) disorders are a group of nine neurodegenerative diseases that share a common genetic cause, which is an expansion of CAG repeats in the…”
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Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5 by Carvalho, Caetana M., Nobre, Rui J., Carreira, Bruno P., Santos, Ana I., Araújo, Inês M.

“…The involvement of nitric oxide (NO) and cyclic GMP (cGMP) in neurogenesis has been progressively unmasked over the last decade. Phosphodiesterase 5 (PDE5)…”
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Gene therapy for Parkinson's and Alzheimer's diseases: from the bench to clinical trials by Nobre, Rui Jorge, Almeida, Luís Pereira de

“…Alzheimer's and Parkinson's diseases represent the most prevalent neurodegenerative disorders worldwide. Current pharmacological or surgical treatments provide…”
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Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease by Simões, Ana Teresa, Gonçalves, Nélio, Nobre, Rui Jorge, Duarte, Carlos Bandeira, Pereira de Almeida, Luís

“…Machado-Joseph Disease (MJD) is the most prevalent autosomal dominantly inherited cerebellar ataxia. It is caused by an expanded CAG repeat in the ATXN3 gene,…”
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Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line by Marques, Ana Patrícia, Rosmaninho-Salgado, Joana, Estrada, Marta, Cortez, Vera, Nobre, Rui Jorge, Cavadas, Cláudia

“…Hypoxia occurs within adipose tissue of obese human and mice. However, its role in adipose tissue regulation is still controversial. We used murine…”
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Trehalose alleviates the phenotype of Machado-Joseph disease mouse models by Santana, Magda M, Paixão, Susana, Cunha-Santos, Janete, Silva, Teresa Pereira, Trevino-Garcia, Allyson, Gaspar, Laetitia S, Nóbrega, Clévio, Nobre, Rui Jorge, Cavadas, Cláudia, Greif, Hagar, Pereira de Almeida, Luís

“…Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is…”
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Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research by Gaspar, Laetitia S., Santana, Magda M., Henriques, Carina, Pinto, Maria M., Ribeiro-Rodrigues, Teresa M., Girão, Henrique, Nobre, Rui Jorge, Pereira de Almeida, Luís

“…Extracellular vesicles (EVs) are membranous structures that protect RNAs from damage when circulating in complex biological fluids, such as plasma. RNAs are…”
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The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples by Duarte Lobo, Diana, Nobre, Rui Jorge, Oliveira Miranda, Catarina, Pereira, Dina, Castelhano, João, Sereno, José, Koeppen, Arnulf, Castelo-Branco, Miguel, Pereira de Almeida, Luís

“…Abstract Blood-brain barrier (BBB) disruption is a common feature in neurodegenerative diseases. However, BBB integrity has not been assessed in…”
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Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease by Miranda, Catarina Oliveira, Nobre, Rui Jorge, Paiva, Vitor Hugo, Duarte, João Valente, Castelhano, João, Petrella, Lorena Itatí, Sereno, José, Santana, Magda, Afonso, Sónia, Januário, Cristina, Castelo-Branco, Miguel, de Almeida, Luís Pereira

“…Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is the most common form of dominant SCA worldwide. Magnetic Resonance Imaging (MRI) and…”
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Isolation of Extracellular Vesicles from Human Follicular Fluid: Size-Exclusion Chromatography versus Ultracentrifugation by Soares, Maria, Pinto, Maria M, Nobre, Rui Jorge, de Almeida, Luís Pereira, da Graça Rasteiro, Maria, Almeida-Santos, Teresa, Ramalho-Santos, João, Sousa, Ana Paula

“…Follicular fluid (FF) is the microenvironment where a growing oocyte develops. Intrafollicular communication ensures oocyte competence and is carried out…”
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Highly specific blood-brain barrier transmigrating single-domain antibodies selected by an In Vivo phage display screening by Aguiar, Sandra Isabel, Dias, Joana, Santos André, Ana Filipa, Silva, Lisete M., Martins, Diana, Carrapiço, Belmira, Castanho, Miguel, Carriço, João, Cavaco, Marco, Aires da Silva, Frederico, [et al.]

“…Research Areas: Pharmacology & Pharmacy A major bottleneck in the successful development of central nervous system (CNS) drugs is the discovery and design of…”
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Uma proposta para a criação de democracias solidárias by Moreira, Rui Nobre

“…The neoliberal ideology, which has prevailed almost everywhere in the world in the last 40 years, has been accentuating them. Today, the existence of a…”
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