Search Results - "Nobre, Ana Rita"

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments by Fluegen, Georg, Avivar-Valderas, Alvaro, Wang, Yarong, Padgen, Michael R., Williams, James K., Nobre, Ana Rita, Calvo, Veronica, Cheung, Julie F., Bravo-Cordero, Jose Javier, Entenberg, David, Castracane, James, Verkhusha, Vladislav, Keely, Patricia J., Condeelis, John, Aguirre-Ghiso, Julio A.

“…Hypoxia is a poor-prognosis microenvironmental hallmark of solid tumours, but it is unclear how it influences the fate of disseminated tumour cells (DTCs) in…”
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The Different Routes to Metastasis via Hypoxia-Regulated Programs by Nobre, Ana Rita, Entenberg, David, Wang, Yarong, Condeelis, John, Aguirre-Ghiso, Julio A.

“…Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this…”
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Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow by Yumoto, Kenji, Eber, Matthew R., Wang, Jingcheng, Cackowski, Frank C., Decker, Ann M., Lee, Eunsohl, Nobre, Ana Rita, Aguirre-Ghiso, Julio A., Jung, Younghun, Taichman, Russell S.

“…Disseminated prostate cancer (PCa) cells in the marrow survive for years without evidence of proliferation, while maintaining the capacity to develop into…”
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p40: A p63 Isoform Useful for Lung Cancer Diagnosis – A Review of the Physiological and Pathological Role of p63 by Nobre, Ana Rita, Albergaria, André, Schmitt, Fernando

“…At present, p63, TTF-1, and Napsin-A are the main immunochemical markers used to distinguish squamous cell carcinoma (SCC) from lung adenocarcinoma (ADC)…”
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A Collaborative Approach for the Development of a Standardized Set of Patient-Centered Outcomes in Head and Neck Cancers by Joaquim, Ana, Nobre, Ana Rita, Araújo, Cláudia, Vieira, Guy, Alves, Paula, Carinha, Paulo, Ribeiro, Leonor

“…Head and neck cancers remain a significant health burden worldwide. Standardizing the care provided to these patients through the systematic measurement of…”
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P-cadherin signals through the laminin receptor α6β4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells by Vieira, André Filipe, Ribeiro, Ana Sofia, Dionísio, Maria Rita, Sousa, Bárbara, Nobre, Ana Rita, Albergaria, André, Santiago-Gómez, Angélica, Mendes, Nuno, Gerhard, Renê, Schmitt, Fernando, Clarke, Robert B, Paredes, Joana

“…P-cadherin is a classical cell-cell adhesion molecule that, in contrast to E-cadherin, has a positive role in breast cancer progression, being considered a…”
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P-cadherin role in normal breast development and cancer by Albergaria, André, Ribeiro, Ana-Sofia, Vieira, André-Filipe, Sousa, Bárbara, Nobre, Ana-Rita, Seruca, Raquel, Schmitt, Fernando, Paredes, Joana

“…P-cadherin is a cell-cell adhesion molecule, whose expression is highly associated with undifferentiated cells in normal adult epithelial tissues, as well as…”
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SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells by Ribeiro, Ana Sofia, Nobre, Ana Rita, Mendes, Nuno, Almeida, João, Vieira, André Filipe, Sousa, Bárbara, Carvalho, Filomena A, Monteiro, Joana, Polónia, António, Fonseca, Martina, Sanches, João Miguel, Santos, Nuno C, Seruca, Raquel, Paredes, Joana

“…Basal-like breast cancer (BLBC) is a poor prognosis subgroup of triple-negative carcinomas that still lack specific target therapies and accurate biomarkers…”
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CCAAT/enhancer binding protein β (C/EBPβ) isoforms as transcriptional regulators of the pro-invasive CDH3/P-cadherin gene in human breast cancer cells by Albergaria, André, Resende, Carlos, Nobre, Ana Rita, Ribeiro, Ana Sofia, Sousa, Bárbara, Machado, José Carlos, Seruca, Raquel, Paredes, Joana, Schmitt, Fernando

“…P-cadherin is a cell-cell adhesion molecule codified by the CDH3 gene, which expression is highly associated with undifferentiated cells in normal adult…”
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Laryngeal chondrosarcoma – Ten years of experience by Oliveira, José Fernando dos Santos, Branquinho, Francisco António Pinto Lopes, Monteiro, Ana Rita Raposeiro Tomé Nobre, Portugal, Maria Edite Correia Castro, Guimarães, Arnaldo Manuel Ferreira Silva

“…Laryngeal involvement by cartilaginous tumors is rare. However, although accounting for only 1% of laryngeal tumor pathology, they are the most frequently…”
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Skip to the end: metastasis before tumorigenesis by Nobre, Ana Rita, Boire, Adrienne

“…Mutations in the sodium channel NALCN promote epithelial cell shedding and dissemination independent of oncogenic transformation. This observation suggests…”
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The current paradigm and challenges ahead for the dormancy of disseminated tumor cells by Risson, Emma, Nobre, Ana Rita, Maguer-Satta, Veronique, Aguirre-Ghiso, Julio A

“…Disseminated tumor cells (DTCs) are known to enter a state of dormancy that is achieved via growth arrest of DTCs and/or a form of population equilibrium…”
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A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy by Di Martino, Julie S, Nobre, Ana Rita, Mondal, Chandrani, Taha, Isra, Farias, Eduardo F, Fertig, Elana J, Naba, Alexandra, Aguirre-Ghiso, Julio A, Bravo-Cordero, Jose Javier

“…Cancer cells disseminate and seed in distant organs, where they can remain dormant for many years before forming clinically detectable metastases. Here we…”
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A dormancy mechanism limits metastasis of early spreading cancer cells

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An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy by Khalil, Bassem D, Sanchez, Roberto, Rahman, Tasrina, Rodriguez-Tirado, Carolina, Moritsch, Stefan, Martinez, Alba Rodriguez, Miles, Brett, Farias, Eduardo, Mezei, Mihaly, Nobre, Ana Rita, Singh, Deepak, Kale, Nupura, Sproll, Karl Christoph, Sosa, Maria Soledad, Aguirre-Ghiso, Julio A

“…We describe the discovery of an agonist of the nuclear receptor NR2F1 that specifically activates dormancy programs in malignant cells. The agonist led to a…”
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Surgical Closure of Tracheoesophageal Puncture Without a Flap Interposition by Neves, João Fonseca, Nobre, Ana Rita, Portugal, Edite, Branquinho, Francisco

“…Tracheoesophageal puncture for voice prosthesis placement is often used in vocal rehabilitation of patients undergoing total laryngectomy. Although its closure…”
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BSLD-06 UNVEILING THE RE-PROGRAMMING OF CHOROID PLEXUS AND LEPTOMENINGEAL METASTASIS by Nobre, Ana Rita, Wang, Helen, Estrera, Rachel, Boire, Adrienne

“…Leptomeningeal metastasis (LM) is an increasingly common, fatal complication of breast and lung cancer. Despite aggressive treatment, neurologic deficits…”
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A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells by Calvo, Veronica, Zheng, Wei, Adam-Artigues, Anna, Staschke, Kirk A, Huang, Xin, Cheung, Julie F, Nobre, Ana Rita, Fujisawa, Sho, Liu, David, Fumagalli, Maria, Surguladze, David, Stokes, Michael E, Nowacek, Ari, Mulvihill, Mark, Farias, Eduardo F, Aguirre-Ghiso, Julio A

“…The integrated stress response (ISR) kinase PERK serves as a survival factor for both proliferative and dormant cancer cells. We aim to validate PERK…”
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Abstract 1492: Unveiling the re-programming of choroid plexus and leptomeningeal metastasis by Nobre, Ana Rita, Wang, Helen, Estrera, Rachel, Osei-Gyening, Isaiah, Boire, Adrienne

“…Leptomeningeal metastasis (LM) is an increasingly common, fatal complication of breast and lung cancer. Despite aggressive treatment, neurologic deficits…”
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Bone marrow NG2 + /Nestin + mesenchymal stem cells drive DTC dormancy via TGFβ2 by Nobre, Ana Rita, Risson, Emma, Singh, Deepak K, Di Martino, Julie S, Cheung, Julie F, Wang, Jiapeng, Johnson, John, Russnes, Hege G, Bravo-Cordero, Jose Javier, Birbrair, Alexander, Naume, Bjorn, Azhar, Mohamad, Frenette, Paul S, Aguirre-Ghiso, Julio A

“…In the bone marrow (BM) microenvironment, where breast cancer (BC) disseminated tumour cells (DTCs) can remain dormant for decades, NG2 /Nestin mesenchymal…”
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