Search Results - "Noble, E."
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A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling
Published in Molecular psychiatry (01-07-2018)“…The hippocampus and the medial prefrontal cortex (mPFC) are traditionally associated with regulating memory and executive function, respectively. The…”
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Gut to Brain Dysbiosis: Mechanisms Linking Western Diet Consumption, the Microbiome, and Cognitive Impairment
Published in Frontiers in behavioral neuroscience (30-01-2017)“…Consumption of a Western Diet (WD) that is high in saturated fat and added sugars negatively impacts cognitive function, particularly mnemonic processes that…”
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3
Quantification of protein concentration using UV absorbance and Coomassie dyes
Published in Methods in enzymology (2014)“…The measurement of a solubilized protein concentration in solution is an important assay in biochemistry research and development labs for applications ranging…”
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4
Spontaneous Deracemizations
Published in Chemical reviews (24-02-2021)“…Spontaneous deracemizations is a challenging, multidisciplinary subject in current chirality research. In the absence of any chiral inductors, an achiral…”
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5
Ultrasonography versus Computed Tomography for Suspected Nephrolithiasis
Published in The New England journal of medicine (18-09-2014)“…Patients with suspected nephrolithiasis were randomly assigned to ultrasonography performed by an emergency physician or a radiologist or to CT for initial…”
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Gut vagal sensory signaling regulates hippocampus function through multi-order pathways
Published in Nature communications (05-06-2018)“…The vagus nerve is the primary means of neural communication between the gastrointestinal (GI) tract and the brain. Vagally mediated GI signals activate the…”
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7
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
Published in Nature communications (07-10-2020)“…COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related…”
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International evidence-based recommendations for point-of-care lung ultrasound
Published in Intensive care medicine (01-04-2012)“…Background The purpose of this study is to provide evidence-based and expert consensus recommendations for lung ultrasound with focus on emergency and critical…”
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9
The lighter side of BDNF
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01-05-2011)“…Brain-derived neurotrophic factor (BDNF) mediates energy metabolism and feeding behavior. As a neurotrophin, BDNF promotes neuronal differentiation, survival…”
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Focused Cardiac Ultrasound in the Emergent Setting: A Consensus Statement of the American Society of Echocardiography and American College of Emergency Physicians
Published in Journal of the American Society of Echocardiography (01-12-2010)“…The use of ultrasound has developed over the last 50 years into an indispensable first-line test for the cardiac evaluation of symptomatic patients. The…”
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Ghrelin and Orexin Interact to Increase Meal Size Through a Descending Hippocampus to Hindbrain Signaling Pathway
Published in Biological psychiatry (1969) (01-06-2020)“…Memory and cognitive processes influence the amount of food consumed during a meal, yet the neurobiological mechanisms mediating these effects are poorly…”
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12
Spatial patterns of tree yield explained by endogenous forces through a correspondence between the Ising model and ecology
Published in Proceedings of the National Academy of Sciences - PNAS (20-02-2018)“…Spatial patterning of periodic dynamics is a dramatic and ubiquitous ecological phenomenon arising in systems ranging from diseases to plants to mammals. The…”
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13
Western Diet Consumption During Development: Setting the Stage for Neurocognitive Dysfunction
Published in Frontiers in neuroscience (10-02-2021)“…The dietary pattern in industrialized countries has changed substantially over the past century due to technological advances in agriculture, food processing,…”
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FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation
Published in Journal of medicinal chemistry (11-04-2019)“…Identifying ligand binding sites on proteins is a critical step in target-based drug discovery. Current approaches to this require resource-intensive screening…”
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CDK1 structures reveal conserved and unique features of the essential cell cycle CDK
Published in Nature communications (13-04-2015)“…CDK1 is the only essential cell cycle CDK in human cells and is required for successful completion of M-phase. It is the founding member of the CDK family and…”
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Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients
Published in Translational psychiatry (01-01-2014)“…Recent studies suggest that genetic and environmental factors do not account for all the schizophrenia risk, and epigenetics also has a role in disease…”
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Emergency Department Point-of-care Ultrasound in Out-of-Hospital and in-ED Cardiac Arrest
Published in Resuscitation (01-12-2016)“…Abstract Background Mortality following cardiac arrest remains high, and point-of-care ultrasound has been suggested to improve outcomes from advanced cardiac…”
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Antimicrobial peptide capsids of de novo design
Published in Nature communications (22-12-2017)“…The spread of bacterial resistance to antibiotics poses the need for antimicrobial discovery. With traditional search paradigms being exhausted, approaches…”
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Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors
Published in Nature communications (13-03-2020)“…The dual protein kinase-transcription factor, ERK5, is an emerging drug target in cancer and inflammation, and small-molecule ERK5 kinase inhibitors have been…”
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Characterizing Species Interactions to Understand Press Perturbations: What Is the Community Matrix?
Published in Annual review of ecology, evolution, and systematics (01-11-2016)“…The community matrix is among ecology's most important mathematical abstractions, formally encapsulating the interconnected network of effects that species…”
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