Melioidosis in patients with suspected tuberculosis in Cambodia: a single-center cross-sectional study

SETTING: Melioidosis-Burkholderia pseudomallei infection-is increasingly recognized in Cambodia, a country with a high incidence of tuberculosis (TB). Melioidosis and TB can be clinically indistinguishable.OBJECTIVE: To quantify the proportion of patients with clinically suspected TB who had melioid...

Full description

Saved in:

Bibliographic Details
Published in:	The international journal of tuberculosis and lung disease Vol. 22; no. 12; pp. 1481 - 1485
Main Authors:	Pho, Y., Nhem, S., Sok, C., By, B., Phann, D., Nob, H., Thann, S., Yin, S., Kim, C., Letchford, J., Fassier, T., Chan, S., West, T. E.
Format:	Journal Article
Language:	English
Published:	France International Union Against Tuberculosis and Lung Disease 01-12-2018 International Union against Tuberculosis and Lung Disease (IUATLD)
Subjects:	Burkholderia Cross-sectional studies Culture Diagnostics Infection Infections Lung Melioidosis Patients Risk analysis Risk factors Sputum Tuberculosis Cambodia
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	SETTING: Melioidosis-Burkholderia pseudomallei infection-is increasingly recognized in Cambodia, a country with a high incidence of tuberculosis (TB). Melioidosis and TB can be clinically indistinguishable.OBJECTIVE: To quantify the proportion of patients with clinically suspected TB who had melioidosis by testing sputum for B. pseudomallei.DESIGN: This was a prospective, 6-month cross-sectional single-center study at a Cambodian provincial referral hospital among patients with suspicion of TB who provided sputum specimens for testing. TB was diagnosed using sputum Xpert® MTB/RIF molecular assay or culture; melioidosis was diagnosed using sputum culture for B. pseudomallei.RESULTS: Of 404 patients evaluated for possible TB, 52 (12.9%, 95%CI 9.8-16.5) had TB. Four patients (1.0%, 95%CI 0.3-2.5) had melioidosis; none had concurrent TB or an existing medical risk factor for melioidosis, although two were farmers, an occupational risk factor.CONCLUSION: One per cent of patients being evaluated for TB at a Cambodian provincial referral hospital had culture-proven respiratory melioidosis, a highly lethal infection. None had previously recognized medical conditions that would increase their risk of melioidosis. Testing for melioidosis should be considered in patients presenting with suspected TB in Cambodia.
Bibliography:	1027-3719(20181201)22:12L.1481;1- (R) Medicine - General ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1027-3719 1815-7920
DOI:	10.5588/ijtld.17.0294