Search Results - "Noël, J"

Accumulation of Plastic Debris and Associated Contaminants in Aquatic Food Webs by Diepens, Noël J, Koelmans, Albert A

“…We present a generic theoretical model (MICROWEB) that simulates the transfer of microplastics and hydrophobic organic chemicals (HOC) in food webs. We…”
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Lifetime Accumulation of Microplastic in Children and Adults by Mohamed Nor, Nur Hazimah, Kooi, Merel, Diepens, Noël J, Koelmans, Albert A

“…Human exposure to microplastic is recognized as a global problem, but the uncertainty, variability, and lifetime accumulation are unresolved. We provide a…”
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Effects of nanoplastics and microplastics on the growth of sediment-rooted macrophytes by van Weert, Sander, Redondo-Hasselerharm, Paula E., Diepens, Noël J., Koelmans, Albert A.

“…Plastic debris of all sizes has been detected in marine, terrestrial and freshwater habitats. Effects of plastic debris on macrophytes have hardly been…”
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Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer by Zhang, Hanghang, Pandey, Somnath, Travers, Meghan, Sun, Hongxing, Morton, George, Madzo, Jozef, Chung, Woonbok, Khowsathit, Jittasak, Perez-Leal, Oscar, Barrero, Carlos A., Merali, Carmen, Okamoto, Yasuyuki, Sato, Takahiro, Pan, Joshua, Garriga, Judit, Bhanu, Natarajan V., Simithy, Johayra, Patel, Bela, Huang, Jian, Raynal, Noël J.-M., Garcia, Benjamin A., Jacobson, Marlene A., Kadoch, Cigall, Merali, Salim, Zhang, Yi, Childers, Wayne, Abou-Gharbia, Magid, Karanicolas, John, Baylin, Stephen B., Zahnow, Cynthia A., Jelinek, Jaroslav, Graña, Xavier, Issa, Jean-Pierre J.

“…Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through RNAPII pause release. We now report that CDK9 is also essential for maintaining…”
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Improving Sediment Toxicity Testing for Very Hydrophobic Chemicals: Part 2—Exposure Duration, Upper Limit Test Concentrations, and Distinguishing Actual Toxicity from Physical Effects by Jonker, Michiel T. O., Diepens, Noël J.

“…Sediment toxicity testing with very hydrophobic organic chemicals (VHOCs) is challenging because of the chemicals’ low aqueous solubilities and slow kinetics…”
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Improving Sediment Toxicity Testing for Very Hydrophobic Chemicals: Part 1—Spiking, Equilibrating, and Exposure Quantification by Jonker, Michiel T. O., Diepens, Noël J.

“…Sediment toxicity tests have applications in ecological risk and chemical safety assessments. Despite the many years of experience in testing and the…”
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DNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas by Malouf, Gabriel G, Su, Xiaoping, Zhang, Jianping, Creighton, Chad J, Ho, Thai H, Lu, Yue, Raynal, Noël J-M, Karam, Jose A, Tamboli, Pheroze, Allanick, Frederick, Mouawad, Roger, Spano, Jean-Philippe, Khayat, David, Wood, Christopher G, Jelinek, Jaroslav, Tannir, Nizar M

“…DNA methylation is a heritable covalent modification that is developmentally regulated and is critical in tissue-type definition. Although genotype-phenotype…”
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Repurposing of rituximab biosimilars to treat B cell mediated autoimmune diseases by Mostkowska, Agata, Rousseau, Guy, Raynal, Noël J‐M

“…Rituximab, the first monoclonal antibody approved for the treatment of lymphoma, eventually became one of the most popular and versatile drugs ever in terms of…”
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Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion by Beaudry, Annie, Jacques-Ricard, Simon, Darracq, Anaïs, Sgarioto, Nicolas, Garcia, Araceli, García, Teresita Rode, Lemieux, William, Béland, Kathie, Haddad, Elie, Cordeiro, Paulo, Duval, Michel, McGraw, Serge, Richer, Chantal, Caron, Maxime, Marois, François, St-Onge, Pascal, Sinnett, Daniel, Banquy, Xavier, Raynal, Noël J.-M.

“…Neuroblastoma, the most common type of pediatric extracranial solid tumor, causes 10% of childhood cancer deaths. Despite intensive multimodal treatment, the…”
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Towards continuous mass and size distributions for beach plastic litter: Spatiotemporal analyses of abundance and composition by Grundlehner, Anne, Diepens, Noël J., Linders, Theo, Peeters, Edwin T.H.M., Koelmans, Albert A.

“…Beaches are known as hotspots for the accumulation of plastic debris and are widely used for monitoring marine litter on a global scale. However, there is a…”
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Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer by Raynal, Noël J-M, Lee, Justin T, Wang, Youjun, Beaudry, Annie, Madireddi, Priyanka, Garriga, Judith, Malouf, Gabriel G, Dumont, Sarah, Dettman, Elisha J, Gharibyan, Vazganush, Ahmed, Saira, Chung, Woonbok, Childers, Wayne E, Abou-Gharbia, Magid, Henry, Ryan A, Andrews, Andrew J, Jelinek, Jaroslav, Cui, Ying, Baylin, Stephen B, Gill, Donald L, Issa, Jean-Pierre J

“…Targeting epigenetic pathways is a promising approach for cancer therapy. Here, we report on the unexpected finding that targeting calcium signaling can…”
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Repositioning FDA-Approved Drugs in Combination with Epigenetic Drugs to Reprogram Colon Cancer Epigenome by Raynal, Noël J-M, Da Costa, Elodie M, Lee, Justin T, Gharibyan, Vazganush, Ahmed, Saira, Zhang, Hanghang, Sato, Takahiro, Malouf, Gabriel G, Issa, Jean-Pierre J

“…Epigenetic drugs, such as DNA methylation inhibitors (DNMTi) or histone deacetylase inhibitors (HDACi), are approved in monotherapy for cancer treatment. These…”
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Ionospheric Sounding and Tomography Using Automatic Identification System (AIS) and Other Signals of Opportunity by Cushley, A. C., Noël, J.‐M.

“…Numerical modeling has demonstrated that Automatic Identification System (AIS) signals can be used not only to estimate vertical total electron content (TEC)…”
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Molybdenum surface enrichment and release during transpassive dissolution of Ni-based alloys by Henderson, Jeffrey D., Li, Xuejie, Shoesmith, David W., Noël, James J., Ogle, Kevin

“…[Display omitted] •Ni, Cr, Mo and Fe dissolution were monitored as a function of time in the passive and transpassive domain.•Mo surface enrichment, probably…”
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DNA Methylation Does Not Stably Lock Gene Expression but Instead Serves as a Molecular Mark for Gene Silencing Memory by RAYNAL, Noël J.-M, JIALI SI, TABY, Rodolphe F, GHARIBYAN, Vazganush, AHMED, Saira, JELINEK, Jaroslav, ESTECIO, Marcos R. H, ISSA, Jean-Pierre J

“…DNA methylation is commonly thought of as a "molecular lock" that leads to permanent gene silencing. To investigate this notion, we tested 24 different histone…”
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Nutrition and protein energy homeostasis in elderly by Boirie, Yves, Morio, Béatrice, Caumon, Elodie, Cano, Noël J.

“…•In elderly, muscle mass, energy expenditure and insulin sensitivity are decreased.•A Mediterranean-like energy supply of approximately 30kcal/kg/day is…”
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Chemogenetic manipulation of the bed nucleus of the stria terminalis counteracts social behavioral deficits induced by early life stress in C57BL/6J mice by Emmons, Randi, Sadok, Tasneem, Rovero, Natalie G., Belnap, Malia A., Henderson, Hannah J. M., Quan, Alex J., Del Toro, Noël J., Halladay, Lindsay R.

“…Trauma during critical periods of development can induce long‐lasting adverse effects. To study neural aberrations resulting from early life stress (ELS), many…”
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Toxicity effects of an environmental realistic herbicide mixture on the seagrass Zostera noltei by Diepens, Noël J., Buffan-Dubau, Evelyne, Budzinski, Hélène, Kallerhoff, Jean, Merlina, Georges, Silvestre, Jérome, Auby, Isabelle, Nathalie Tapie, Elger, Arnaud

“…Worldwide seagrass declines have been observed due to multiple stressors. One of them is the mixture of pesticides used in intensive agriculture and boat…”
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Hydrogen peroxide decomposition on simulated nuclear fuel bicarbonate/carbonate solutions by Zhu, Ziyan, Noël, James J., Shoesmith, David W.

“…The behavior of SIMFUEL (rare earth doped uranium dioxide containing noble metal particles) has been studied in bicarbonate/carbonate solutions (pH = 9.7)…”
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Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells by Dominici, Claudia, Sgarioto, Nicolas, Yu, Zhenbao, Sesma-Sanz, Laura, Masson, Jean-Yves, Richard, Stéphane, Raynal, Noël J-M

“…Non-small cell lung carcinoma (NSCLC) is a leading cause of cancer-related death and represents a major health burden worldwide. Current therapies for NSCLC…”
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