Search Results - "Noël, Emily S."

The ECM as a driver of heart development and repair by Derrick, Christopher J, Noël, Emily S

“…The developing heart is formed of two tissue layers separated by an extracellular matrix (ECM) that provides chemical and physical signals to cardiac cells…”
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Genome-wide RNA Tomography in the Zebrafish Embryo by Junker, Jan Philipp, Noël, Emily S., Guryev, Victor, Peterson, Kevin A., Shah, Gopi, Huisken, Jan, McMahon, Andrew P., Berezikov, Eugene, Bakkers, Jeroen, van Oudenaarden, Alexander

“…Advancing our understanding of embryonic development is heavily dependent on identification of novel pathways or regulators. Although genome-wide techniques…”
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Zebrafish as a tractable model of human cardiovascular disease by Bowley, George, Kugler, Elizabeth, Wilkinson, Rob, Lawrie, Allan, Eeden, Freek, Chico, Tim J. A., Evans, Paul C., Noël, Emily S., Serbanovic‐Canic, Jovana

“…Mammalian models including non‐human primates, pigs and rodents have been used extensively to study the mechanisms of cardiovascular disease. However, there is…”
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Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration by Wu, Chi-Chung, Kruse, Fabian, Vasudevarao, Mohankrishna Dalvoy, Junker, Jan Philipp, Zebrowski, David C., Fischer, Kristin, Noël, Emily S., Grün, Dominic, Berezikov, Eugene, Engel, Felix B., van Oudenaarden, Alexander, Weidinger, Gilbert, Bakkers, Jeroen

“…In contrast to mammals, zebrafish regenerate heart injuries via proliferation of cardiomyocytes located near the wound border. To identify regulators…”
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Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle by Pollitt, Eric J G, Sánchez-Posada, Juliana, Snashall, Corinna M, Derrick, Christopher J, Noël, Emily S

“…During heart development, the embryonic ventricle becomes enveloped by the epicardium, which adheres to the outer apical surface of the heart. This is…”
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A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality by Noël, Emily S., Verhoeven, Manon, Lagendijk, Anne Karine, Tessadori, Federico, Smith, Kelly, Choorapoikayil, Suma, den Hertog, Jeroen, Bakkers, Jeroen

“…Breaking left–right symmetry in bilateria is a major event during embryo development that is required for asymmetric organ position, directional organ looping…”
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A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function by Noël, Emily S., Momenah, Tarek S., Al-Dagriri, Khalid, Al-Suwaid, Abdulrahman, Al-Shahrani, Safar, Jiang, Hui, Willekers, Sven, Oostveen, Yara Y., Chocron, Sonja, Postma, Alex V., Bhuiyan, Zahurul A., Bakkers, Jeroen

“…ABSTRACT Establishing correct left–right asymmetry during embryonic development is crucial for proper asymmetric positioning of the organs. Congenital heart…”
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Contemporary morphogenesis by Campbell, Kyra, Noël, Emily S, Fletcher, Alexander G, Bulgakova, Natalia A

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Lamb1a regulates atrial growth by limiting second heart field addition during zebrafish heart development by Derrick, Christopher J, Pollitt, Eric J G, Sanchez Sevilla Uruchurtu, Ashley, Hussein, Farah, Grierson, Andrew J, Noël, Emily S

“…During early vertebrate heart development, the heart transitions from a linear tube to a complex asymmetric structure, a morphogenetic process that occurs…”
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Nodal Signaling Range Is Regulated by Proprotein Convertase-Mediated Maturation by Tessadori, Federico, Noël, Emily S., Rens, Elisabeth G., Magliozzi, Roberto, Evers-van Gogh, Inkie J.A., Guardavaccaro, Daniele, Merks, Roeland M.H., Bakkers, Jeroen

“…Tissue patterning is established by extracellular growth factors or morphogens. Although different theoretical models explaining specific patterns have been…”
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Organ-specific requirements for Hdac1 in liver and pancreas formation by Noël, Emily S., Casal-Sueiro, Antonio, Busch-Nentwich, Elisabeth, Verkade, Heather, Dong, P. Duc Si, Stemple, Derek L., Ober, Elke A.

“…Liver, pancreas and lung originate from the presumptive foregut in temporal and spatial proximity. This requires precisely orchestrated transcriptional…”
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Analysis of the Albumin/α-Fetoprotein/Afamin/Group specific component gene family in the context of zebrafish liver differentiation by Noël, Emily S., Reis, Mario dos, Arain, Zoya, Ober, Elke A.

“…Members of the Albumin/α-Fetoprotein/Afamin/Group specific component ( Alb/Afp/Afm/Gc) multi-gene family perform physiological functions essential for body…”
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Cardiac construction-Recent advances in morphological and transcriptional modeling of early heart development by Noël, Emily S

“…During human embryonic development the early establishment of a functional heart is vital to support the growing fetus. However, forming the embryonic heart is…”
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Twists and turns by Noël, Emily S, Bakkers, Jeroen

“…Computational modelling of the heart tube during development reveals the interplay between tissue asymmetry and growth that helps our hearts take shape…”
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Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development by Derrick, Christopher J, Sánchez-Posada, Juliana, Hussein, Farah, Tessadori, Federico, Pollitt, Eric J G, Savage, Aaron M, Wilkinson, Robert N, Chico, Timothy J, van Eeden, Fredericus J, Bakkers, Jeroen, Noël, Emily S

“…Abstract Aims Vertebrate heart development requires the complex morphogenesis of a linear tube to form the mature organ, a process essential for correct…”
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Chromatin Modification in Zebrafish Development by Mas, Jordi Cayuso, Noël, Emily S., Ober, Elke A.

“…The generation of complex organisms requires that an initial population of cells with identical gene expression profiles can adopt different cell fates during…”
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A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function: HUMAN MUTATION by Noël, Emily S., Momenah, Tarek S., Al-Dagriri, Khalid, Al-Suwaid, Abdulrahman, Al-Shahrani, Safar, Jiang, Hui, Willekers, Sven, Oostveen, Yara Y., Chocron, Sonja, Postma, Alex V., Bhuiyan, Zahurul A., Bakkers, Jeroen

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Analysis of the Albumin/a-Fetoprotein/Afamin/Group specific component gene family in the context of zebrafish liver differentiation by Noel, Emily S, Dos Reis, Mario, Arain, Zoya, Ober, Elke A

“…Members of the Albumin/a-Fetoprotein/Afamin/Group specific component (Alb/Afp/Afm/Gc) multi-gene family perform physiological functions essential for body…”
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